Publication Date:
1991-06-14
Description:
The identification of specialized areas in the mammalian neocortex, such as the primary visual or somatosensory cortex, is based on distinctions in architectural and functional features. The extent to which certain features that distinguish neocortical areas in rats are prespecified or emerge as a result of epigenetic interactions was investigated. Late embryonic visual cortex transplanted to neonatal somatosensory cortex was later assayed for "barrels," anatomically identified functional units unique to somatosensory cortex, and for boundaries of glycoconjugated molecules associated with barrels. Barrels and boundaries form in transplanted visual cortex and are organized in an array that resembles the pattern in the normal barrelfield. These findings show that different regions of the developing neocortex have similar potentials to differentiate features that distinguish neocortical areas and contribute to their unique functional organizations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schlaggar, B L -- O'Leary, D D -- P01 NS17763/NS/NINDS NIH HHS/ -- R01 EY07025/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1991 Jun 14;252(5012):1556-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Neurobiology Laboratory, Salk Institute, La Jolla, CA 92037.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2047863" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylcholinesterase/*analysis
;
Aging
;
Animals
;
Animals, Newborn
;
Brain Tissue Transplantation/*physiology
;
Fetal Tissue Transplantation/physiology
;
Glycoconjugates/analysis
;
Microscopy, Fluorescence
;
Neurons/cytology/enzymology/physiology
;
Rats
;
Rats, Inbred Strains
;
Reference Values
;
Somatosensory Cortex/cytology/growth & development/*physiology
;
Transplantation, Heterotopic
;
Visual Cortex/cytology/*physiology/transplantation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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