ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

11

Electronic Resource

Role of altered prednisolone-specific lymphocyte sensitivity in chronic renal failure as a pharmacodynamic marker of acute allograft rejection after kidney transplantation (1991)

Kang, X. -X. ; Hirano, T. ; Oka, K. ; [et al.]

Springer

European journal of clinical pharmacology 41 (1991), S. 417-423

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ISSN: 1432-1041

Keywords: Kidney transplantation ; Lymphocyte sensitivity ; Prednisolone ; chronic renal failure ; acute allograft rejection

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The effects of four immunosuppressive agents on the in vitro blastogenesis of peripheral blood lymphocytes activated by concanavalin A have been studied using cells from 26 healthy subjects, 34 patients with chronic renal failure (CRF) and 30 kidney transplant recipients. Differences in lymphocyte sensitivity to prednisolone between the healthy subjects and the CRF patients were statistically significant (P〈0.0002), with impaired sensitivity in CRF. Impaired lymphocyte sensitivity occurred in 3.8% and 52.9% of the healthy and CRF subjects, respectively. Lymphocyte sensitivity to prednisolone, both preoperatively and 3 months post-operatively, was strongly correlated with early allograft rejection during co-administration of prednisolone with cyclosporin or azathioprine. Lymphocyte sensitivity to cyclosporin, azathioprine, and mizoribine in CRF was not significantly less than that in healthy subjects. Since the pharmacokinetics of prednisolone are little altered in renal transplantation, it is concluded that lymphocyte sensitivity specific to prednisolone may be a pharmacodynamic marker characteristic of successful graft survival in patients with histo-incompatibility and/or drug resistance.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00626362

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12

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Thyroid hormone concentrations in the gonads of wild chum salmon during maturation (1994)

Tagawa, M. ; Ogasawara, T. ; Sakamoto, T. ; [et al.]

Springer

Fish physiology and biochemistry 13 (1994), S. 233-240

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ISSN: 1573-5168

Keywords: thyroid hormones in maturing gonads ; ovary ; testis ; thyroxin ; triiodothyronine ; teleost

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract Changes in gonadal and plasma concentrations of thyroid hormones were examined at various stages of maturation in chum salmon (Oncorhynchus keta) caught in the Bering Sea and the Bay of Alaska. Plasma concentrations of thyroxine (T4) were less than 5 ng ml−1, and those of 3,5,3′-triiodo-L-thyroxine (T3) were less than 2 ng ml−1 I in both males and females, regardless of the degree of sexual maturity or the gonadosomatic index (GSI). There was no clear relationships between circulating thyroid hormone levels and tissue levels. The ovarian T4 concentrations were undetectable (less than 0.2 ng g−1) or less than 2 ng g−1 when GSI was lower than 1%, but increased thereafter and reached a plateau of 8–10 ng g−1 when GSI became 2%. The ovarian T3 concentrations were about 5 ng g−1 when GSI was 1%, increased to a maximum level (20 ng g−1) when GSI was about 2%, and decreased to a constant level of 10 ng g−1 thereafter. The T4 and T3 content in single oocyte increased proportionally to the oocyte volume, indicating a constant incorporation of the hormones into the oocyte. The T4 concentrations in the testis were 1 ng g−1 or less regardless of the GS1. On the other hand, the T3 concentrations were highest (15 ng g−1) when the GSI was less than 1%, decreased thereafter when spermatocytes appeared in the testis, and became about 5 ng g−1 I in testes containing spermatozoa, raising the possibility of a role for T3 during early gamete and/or gonad maturation of testes.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00004361

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13

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Osmoregulatory ability of chum salmon,Oncorhynchus keta, reared in fresh water for prolonged periods (1987)

Hasegawa, S. ; Hirano, T. ; Ogasawara, T. ; [et al.]

Springer

Fish physiology and biochemistry 4 (1987), S. 101-110

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ISSN: 1573-5168

Keywords: chum salmon ; osmoregulation ; prolactin ; growth hormone ; cortisol ; thyroxine

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract The osmoregulatory ability of chum salmon (Oncorhynchus keta), reared in fresh water for a prolonged period, was examined by transferring them directly to seawater and then back to fresh water. When fry and juveniles weighing 0.3–125g, reared in fresh water for 1.5–13 months, were transferred directly to seawater, they adjusted their plasma Na+ concentration to the seawater-adapted level within 12–24h. When they were transferred back to fresh water after having been adapted to seawater for 2 weeks, the plasma Na+ level gradually decreased during the first 12–24h, and then increased to reattain the initial freshwater level after 5–7 days. No mortality was observed during the experiment except among the smallest fry weighing about 0.3g after transfer to seawater (2.1%). The maintenance of good osmoregulatory ability of the chum salmon for a prolonged period in fresh water seems to be unique among Pacific salmon, with the possible exception of the pink salmon. Changes in plasma levels of hormones during the transfer experiments were recorded in juveniles reared in fresh water for 13 months. Prolactin levels increased maximally 3 days after transfer from seawater to fresh water, as would be expected from its well-established role in freshwater adaptation in several euryhaline teleosts. In addition, an increase in plasma growth hormone was observed during the first 12h after seawater transfer, along with a tendency towards a decrease during freshwater transfer, suggesting an important role for this hormone in seawater adaptation. There were no consistent changes in plasma levels of thyroxine and cortisol during freshwater to seawater or seawater to freshwater transfer.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02044319

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14

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Sintering and characterization of fully dense aluminium nitride ceramics (1993)

Hirano, M. ; Kato, K. ; Isobe, T. ; [et al.]

Springer

Journal of materials science 28 (1993), S. 4725-4730

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ISSN: 1573-4803

Source: Springer Online Journal Archives 1860-2000

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: Abstract Aluminium nitride ceramics with no sintering additives could be densified to close to theoretical density (99.6% theoretical) by pressureless sintering of tape-cast green sheets at 1900 °C for 8 h. The thermal conductivity and bending strength of the specimens were 114 Wm−1 K−1 and 240 MPa, respectively. The effect of Y2O3 additive on sinterability, thermal conductivity and microstructure of aluminium nitride ceramics was investigated. Thermal conductivity increased with increasing amount of Y2O3 additive, sintering temperature and holding time at the sintering temperature. Samples with a thermal conductivity up to 258 Wm−1 K−1 were fabricated by elimination of the grain-boundary phase.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00414264

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15

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High temperature deformation behaviour of MoSi2 and WSi2 single crystals (1990)

Kimura, K. ; Nakamura, M. ; Hirano, T.

Springer

Journal of materials science 25 (1990), S. 2487-2492

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ISSN: 1573-4803

Source: Springer Online Journal Archives 1860-2000

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: Abstract High temperature deformation behaviour of MoSi2 and WSi2 single crystals, which both oriented near 〈001〉 and near 〈100〉, have been studied by compression tests over the temperature range of 1100 to 1500° C in a high vacuum of less than 6×10−4 Pa. At elevated temperatures, several per cent compression deformation is possible in both MoSi2 and WSi2. Slips on {110∼ and {013∼ planes, the dislocation with the direction of Burgers vector 〈331〉 and the stacking fault on {110∼ plane are observed in both deformed MoSi2 and WSi2. In MoSi2, the 0.2% offset stress of the sample oriented 〈001〉 is higher than that of the sample oriented 〈100〉. The higher strength of the sample oriented 〈001〉 is related to the higher CRSS for the main slip plane of it. The reverse orientation dependence of the strength in WSi2 is also correlated with the difference in CRSS on {110∼ and {013∼ planes, which shows the opposite result to MoSi2. The higher CRSS on {110∼ plane in WSi2 compared to that on {013∼ may be caused by the formation of a large number of stacking faults on {110∼ plane.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00638047

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16

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Effects of changes in environmental calcium on prolactin secretion in Japanese eel, Anguilla japonica (1993)

Arakawa, E. ; Hasegawa, S. ; Kaneko, T. ; [et al.]

Springer

Journal of comparative physiology 163 (1993), S. 99-106

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ISSN: 1432-136X

Keywords: Prolactin ; Growth hormone ; Calcium ; Pituitary ; Eel, Anguilla japonica

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract Effects of changes in environmental Ca2+ on the secretion of prolactin, a possible hypercalcemic hormone, were examined both in vivo and in vitro in the Japanese ecl, Anguilla japonica. Transfer of seawater- or freshwater-adapted fish to fresh water, fresh water containing 10 mmol Ca2+ · 1-1 sea water, Ca2+-free sea water, or deionized water was accompanied by significant changes in plasma Ca2+ levels after 7 days, except for the fish transferred from fresh water to fresh water and from sea water to sea water. Changes in external Ca2+ concentrations did not affect plasma prolactin levels, although plasma prolactin levels as well as pituitary prolactin contents were significantly greater in fish in a hypotonic environment than those in a hypertonic environment, regardless of the external Ca2+ concentration. Hypercalcemia, induced by removal of the corpuscles of Stannius, did not alter plasma prolactin levles. Incubation of the pituitary in the medium with different Ca2+ concentrations (up to 2.9 mmol·l-1) did not affect the basal release of prolactin, except at an extremely low Ca2+ concentration (less than 0.1 mmol·l-1) where prolactin release was inhibited. Addition of Ca2+ ionophore (A23187) to the medium led to a marked and significant increase in prolactin release, indicating that an increase in intracellular Ca2+ stimulates prolactin release. However, the effect was not specific to prolactin cells; a similar increase was seen in growth hormone release. These results indicate that changes in environmental Ca2+ concentration may not be the primary factor influencing prolactin secretion in the eel; changes in environmental osmolality or Na+ levels seem to be more critical for the regulation of prolactin secretion.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00263593

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17

Electronic Resource

Studies on irradiation of agar-agar in the solid state: On the changes of textural property of agar-agar hydrogel produced by irradiation (1989)

Nisizawa, M. ; Hirano, T.

New York : Wiley-Blackwell

Journal of Polymer Science: Polymer Letters Edition 27 (1989), S. 123-125

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ISSN: 0887-6258

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Additional Material: 2 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/pol.1989.140270403

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18

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Studies on irradiation of agar-agar in the solid state: On the changes of X-ray diffraction of agar-agar film produced by irradiation (1990)

Nisizawa, M. ; Hirano, T.

New York, NY [u.a.] : Wiley-Blackwell

Journal of Applied Polymer Science 39 (1990), S. 2173-2178

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ISSN: 0021-8995

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: Solid agar-agar was irradiated with 60Co gamma-rays, dissolved in aqueous solutions, molded and made a thin film. Effects of radiation on the ordered conformation of agar-agar molecule were studied by measuring the X-ray diffraction intensity at different radiation doses, elapsed times after irradiation, and concentrations of added substances (sugar and starch). Empirical equations in changes of X-ray diffraction were obtained.

Additional Material: 5 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/app.1990.070391012

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