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  • Analytical Chemistry and Spectroscopy  (1,405)
  • LUNAR AND PLANETARY EXPLORATION  (1,016)
  • Animals  (748)
  • Aerodynamics
  • 1990-1994  (1,599)
  • 1985-1989  (1,581)
  • 1935-1939  (4)
Collection
Keywords
Publisher
Years
Year
  • 1
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    Human recombinant granulocyte-macrophage colony-stimulating factor: a multilineage hematopoietin (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-12-06
    Description: Human recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) was tested for its ability to induce colony formation in human bone marrow that had been enriched for progenitor cells. In addition to its expected granulocyte-monocyte colony-stimulating activity, the recombinant GM-CSF had burst-promoting activity for erythroid burst-forming units and also stimulated colonies derived from multipotent (mixed) progenitors. In contrast, recombinant erythroid-potentiating activity did not stimulate erythroid progenitors. The experiments prove that human GM-CSF has multilineage colony-stimulating activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sieff, C A -- Emerson, S G -- Donahue, R E -- Nathan, D G -- Wang, E A -- Wong, G G -- Clark, S C -- New York, N.Y. -- Science. 1985 Dec 6;230(4730):1171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3877981" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Marrow/*drug effects ; Colony-Stimulating Factors/biosynthesis/*pharmacology ; DNA/genetics ; Dose-Response Relationship, Drug ; Erythroblasts/drug effects ; Granulocytes/*drug effects ; Humans ; Macrophages/*drug effects ; Mice ; Recombinant Proteins/*pharmacology ; Stem Cells/drug effects ; T-Lymphocytes/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Anomalous scattering behavior of selected impact parabola features: Magellan cycle-to-cycle comparisons (1992)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: Magellan observations indicate that many venusian impact craters have associated surfaces, typically lower in backscatter and emissivity than the surroundings, that extend up to hundreds of kilometers to the west of craters, in parabolic planforms. During Magellan's second mapping cycle, a number of these parabolic features were imaged for a second time, under a different viewing geometry. In some cases, the SAR backscatter appearance of portions of the parabolic features was quite different in the two datasets. We present a description and preliminary interpretations of the anomalous appearance of these features as observed during Magellan's first and second mapping cycles.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Lunar and Planetary Inst., Papers Presented to the International Colloquium on Venus; p 92-93
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 3
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    Voyager radio science observations of Neptune and Triton (1989)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Voyager 2 undertook radio science investigations of the Neptune and Triton masses and densities, as well as of their atmospheric and ionospheric vertical structures, the atmospheric composition and low-order gravitational harmonics of Neptune, and ring material characteristics. Upon probing the atmosphere of Neptune to a pressure level of about 500,000 Pa, the effects of a methane cloud region and of ammonia absorption below the cloud have become apparent. The tenuous neutral atmosphere of Triton produced distinct signatures in the occultation data; it is inferred that the Triton atmosphere is controlled by water-pressure equilibrium with surface ices.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Science (ISSN 0036-8075); 246; 1466-147
    Format: text
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    NASA TECHNICAL REPORTS
  • 4
    Electronic Resource
    Electronic Resource
    Letters to the editor (1985)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 20 (1985), S. 422-431 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210200608
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Electron impact fragmentation of pyranocoumarin derivatives. Tandem mass spectrometric study of abundant singly and doubly charged fragment ions at high and low collision energyA preliminary account of this work was presented as a poster at the 12th IMSC, 20-24 August 1991. (1992)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 27 (1992), S. 597-603 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A series of novel pyranocoumarin derivatives were analysed by electron impact mass spectrometry and tandem mass spectrometry at low aud high collision energy. The collision-induced decomposition tandem mass spectra of the [M — CH3]+ ions yielded several structurally valuable fragments and those of the [M — CH3]2+ ions allowed some charge-separation reactions to be recognized.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210270510
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    Paper (German National Licenses)
    Fulltext
  • 6
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    Increased osteoclast development after estrogen loss: mediation by interleukin-6 (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-07-03
    Description: Osteoclasts, the cells that resorb bone, develop from hematopoietic precursors of the bone marrow under the control of factors produced in their microenvironment. The cytokine interleukin-6 can promote hematopoiesis and osteoclastogenesis. Interleukin-6 production by bone and marrow stromal cells is suppressed by 17 beta-estradiol in vitro. In mice, estrogen loss (ovariectomy) increased the number of colony-forming units for granulocytes and macrophages, enhanced osteoclast development in ex vivo cultures of marrow, and increased the number of osteoclasts in trabecular bone. These changes were prevented by 17 beta-estradiol or an antibody to interleukin-6. Thus, estrogen loss results in an interleukin-6-mediated stimulation of osteoclastogenesis, which suggests a mechanism for the increased bone resorption in postmenopausal osteoporosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jilka, R L -- Hangoc, G -- Girasole, G -- Passeri, G -- Williams, D C -- Abrams, J S -- Boyce, B -- Broxmeyer, H -- Manolagas, S C -- AI21761/AI/NIAID NIH HHS/ -- AR41313/AR/NIAMS NIH HHS/ -- CA36464/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1992 Jul 3;257(5066):88-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Veterans Affairs Medical Center, Indiana University School of Medicine, Indianapolis 46202.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1621100" target="_blank"〉PubMed〈/a〉
    Keywords: Analysis of Variance ; Animals ; Antibodies, Monoclonal ; Bone Marrow Cells ; Cells, Cultured ; Estradiol/*pharmacology ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology ; Immunoglobulin G ; Interleukin-6/immunology/*physiology ; Mice ; Osteoclasts/*cytology/drug effects ; *Ovariectomy ; Recombinant Proteins/pharmacology ; Spleen/cytology ; Stem Cells/cytology/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Recombinant gene expression in vivo within endothelial cells of the arterial wall (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-06-16
    Description: A technique for the transfer of endothelial cells and expression of recombinant genes in vivo could allow the introduction of proteins of therapeutic value in the management of cardiovascular diseases. Porcine endothelial cells expressing recombinant beta-galactosidase from a murine amphotropic retroviral vector were introduced with a catheter into denuded iliofemoral arteries of syngeneic animals. Arterial segments explanted 2 to 4 weeks later contained endothelial cells expressing beta-galactosidase, an indication that they were successfully implanted on the vessel wall.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nabel, E G -- Plautz, G -- Boyce, F M -- Stanley, J C -- Nabel, G J -- New York, N.Y. -- Science. 1989 Jun 16;244(4910):1342-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0650.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2499928" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catheterization, Peripheral ; DNA, Recombinant ; Endothelium, Vascular/*cytology/enzymology/transplantation ; Female ; Galactosidases/*biosynthesis ; Genetic Vectors ; Iliac Artery/cytology ; Retroviridae ; Swine ; Swine, Miniature ; beta-Galactosidase/*biosynthesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-11-03
    Description: Rejection of bone marrow grafts in irradiated mice is mediated by natural killer (NK) cells and is controlled by genes linked to the major histocompatibility complex (MHC). It has, however, not been possible to identify the genes or their products. An MHC class I (Dd) transgene introduced in C57BL donors prevented the rejection of their bone marrow by NK cells in irradiated allogeneic and F1 hybrid mice expressing the Dd gene. Conversely, H-2Dd transgenic C57BL recipients acquired the ability to reject bone marrow from C57BL donors but not from H-2Dd transgenic C57BL donors. These results provide formal evidence that NK cells are part of a system capable of rejecting cells because they lack normal genes of the host type, in contrast to T cells, which recognize cells that contain abnormal or novel sequences of non-host type.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ohlen, C -- Kling, G -- Hoglund, P -- Hansson, M -- Scangos, G -- Bieberich, C -- Jay, G -- Karre, K -- 1 ROI CA 44882-01/CA/NCI NIH HHS/ -- 5 ROI CA-25250-06/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1989 Nov 3;246(4930):666-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2814488" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Marrow Transplantation ; *Genes, MHC Class I ; *Graft Rejection ; H-2 Antigens/*genetics ; Killer Cells, Natural/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Transplantation, Homologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Structure and function of human amphiregulin: a member of the epidermal growth factor family (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-02-24
    Description: The complete amino acid sequence of amphiregulin, a bifunctional cell growth modulator, was determined. The truncated form contains 78 amino acids, whereas a larger form of amphiregulin contains six additional amino acids at the amino-terminal end. The amino-terminal half of amphiregulin is extremely hydrophilic and contains unusually high numbers of lysine, arginine, and asparagine residues. The carboxyl-terminal half of amphiregulin (residues 46 to 84) exhibits striking homology to the epidermal growth factor (EGF) family of proteins. Amphiregulin binds to the EGF receptor but not as well as EGF does. Amphiregulin fully supplants the requirement for EGF or transforming growth factor-alpha in murine keratinocyte growth, but it is a much weaker growth stimulator in other cell systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shoyab, M -- Plowman, G D -- McDonald, V L -- Bradley, J G -- Todaro, G J -- New York, N.Y. -- Science. 1989 Feb 24;243(4894 Pt 1):1074-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Oncogen, Seattle, WA 98121.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2466334" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amphiregulin ; Animals ; Binding, Competitive ; Cell Division ; EGF Family of Proteins ; Epidermal Growth Factor/physiology ; Epidermis/cytology ; Glycoproteins/*physiology ; Growth Substances/*physiology ; Humans ; *Intercellular Signaling Peptides and Proteins ; Keratins/metabolism ; Mice ; Molecular Sequence Data ; Radioligand Assay ; Receptor, Epidermal Growth Factor/metabolism ; Sequence Homology, Nucleic Acid ; Transforming Growth Factors/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Site-specific gene expression in vivo by direct gene transfer into the arterial wall (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-09-14
    Description: A recombinant beta-galactosidase gene has been expressed in a specific arterial segment in vivo by direct infection with a murine amphotropic retroviral vector or by DNA transfection with the use of liposomes. Several cell types in the vessel wall were transduced, including endothelial and vascular smooth muscle cells. After retroviral infection, a recombinant reporter gene was expressed for at least 5 months, and no helper virus was detected. Recombinant gene expression achieved by direct retroviral infection or liposome-mediated DNA transfection was limited to the site of infection and was absent from liver, lung, kidney, and spleen. These results demonstrate that site-specific gene expression can be achieved by direct gene transfer in vivo and could be applied to the treatment of such human diseases as atherosclerosis or cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nabel, E G -- Plautz, G -- Nabel, G J -- AI 29179/AI/NIAID NIH HHS/ -- DK 42706/DK/NIDDK NIH HHS/ -- GM-13457/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 Sep 14;249(4974):1285-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109-0650.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2119055" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/genetics ; Animals ; Arteries/*metabolism ; Catheterization, Peripheral ; *Gene Expression ; Hexadimethrine Bromide ; Liposomes ; Methods ; Moloney murine leukemia virus/genetics ; Promoter Regions, Genetic/genetics ; Swine ; *Transfection ; beta-Galactosidase/biosynthesis/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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