Publication Date:
1994-08-05
Description:
A Drosophila gene that contains both a paired box and a homeobox and has extensive sequence homology to the mouse Pax-6 (Small eye) gene was isolated and mapped to chromosome IV in a region close to the eyeless locus. Two spontaneous mutations, ey2 and eyR, contain transposable element insertions into the cloned gene and affect gene expression, particularly in the eye primordia. This indicates that the cloned gene encodes ey. The finding that ey of Drosophila, Small eye of the mouse, and human Aniridia are encoded by homologous genes suggests that eye morphogenesis is under similar genetic control in both vertebrates and insects, in spite of the large differences in eye morphology and mode of development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Quiring, R -- Walldorf, U -- Kloter, U -- Gehring, W J -- New York, N.Y. -- Science. 1994 Aug 5;265(5173):785-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, University of Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7914031" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Aniridia/*genetics
;
Base Sequence
;
DNA Transposable Elements/physiology
;
DNA-Binding Proteins/*genetics
;
Drosophila/embryology/*genetics
;
*Drosophila Proteins
;
Eye/chemistry
;
Eye Proteins
;
Genes, Homeobox
;
*Homeodomain Proteins
;
Humans
;
Larva/genetics
;
Mice
;
Mice, Mutant Strains/*genetics
;
Molecular Sequence Data
;
Paired Box Transcription Factors
;
RNA, Messenger/analysis
;
Regulatory Sequences, Nucleic Acid/physiology
;
Repressor Proteins
;
Sequence Homology, Amino Acid
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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