ISSN:
1573-8221
Keywords:
urokinase
;
growth factors
;
smooth muscle cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The role of urokinase (serine protease converting plasminogen into plasmin) and its receptor in cell migration was studied on cultured smooth muscle cells from rat aorta. Platelet-derived growth factor, fibroblast growth factor-2, and urokinase activated migration of smooth muscle cells. Antibodies against urokinase inhibited cell migration induced by both urokinase and other growth factors. It is assumed that urokinase is involved in vascular remodeling induced by growth factors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02433349
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