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  • 1
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    Electrospun and Electrosprayed Formulations for Drug Delivery (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
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    Chapter 2 Viking camps: A historiographical overview (2023)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-04-04
    Description: This paper presents a broad-reaching overview of the study of Viking camps, and how this has developed since the 1970s. The paper considers how the camps have been interpreted in the past, summarises the evidence of the individual sites which have been investigated, and draws out a number of key themes which have emerged in recent research on the subject, both in this volume and elsewhere.
    Keywords: Viking Camps, Ireland, England, Sweden, Frankia, Iberia, winter camps, Viking military camps, Viking Encampment, viking economy, archaeology, Viking archaeology, history, Viking Studies. ; thema EDItEUR::N History and Archaeology::NK Archaeology
    Language: English
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  • 3
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    Nanofibres in Drug Delivery (2021)
    UCL Press
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    Publication Date: 2023-04-18
    Description: In recent years there has been an explosion of interest in the production of nanoscale fibres for drug delivery and tissue engineering. Nanofibres in Drug Delivery aims to outline to new researchers in the field the utility of nanofibres in drug delivery, and to explain to them how to prepare fibres in the laboratory. The book begins with a brief discussion of the main concepts in pharmaceutical science. The authors then introduce the key techniques that can be used for fibre production and explain briefly the theory behind them. They discuss the experimental implementation of fibre production, starting with the simplest possible set-up and then moving on to consider more complex arrangements. As they do so, they offer advice from their own experience of fibre production, and use examples from current literature to show how each particular type of fibre can be applied to drug delivery. They also consider how fibre production could be moved beyond the research laboratory into industry, discussing regulatory and scale-up aspects.
    Keywords: Nanofibres ; Drugs ; Drug delivery ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries ; bic Book Industry Communication::M Medicine::MM Other branches of medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMZ Therapy & therapeutics
    Language: English
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  • 4
    Electronic Resource
    Electronic Resource
    Qualitative effects of asulam and glyphosate on swards dominated by bracken (Pteridium aquilinum (L.) Kuhn) (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Grass and forage science 32 (1977), S. 0 
    Details
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The initial effect on the underlying sward of spraying bracken with 4.5 kg ha−1 a.i. asulam or 2.0 kg ha−1 a.i. glyphosate was to cause some damage which was greater if glyphosate was used rather than asulam or if treatment was carried out in August rather than in July. Agrostis species were especially susceptible while Festuca species were resistant. The recolonization of areas of bare ground after spraying was primarily by Holcus moliis, Anthoxanthum odoratum, Galium hercynicum and Potentilla erecta, but the population of the latter two species decreased as Agrostis became reestablished. If Digitalis purpurea, Urtica dioica or Cirsium arvense were present originally, heavy infestations developed following the use of asulam, with a smaller increase after glyphosate spraying. In all cases, by the end of three years after treatment, grasses occupied a greater area of the sward in treated than in control plots.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2494.1977.tb01427.x
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  • 5
    Electronic Resource
    Electronic Resource
    The effects of asulam, frond cutting and ground mineral phosphate on the yields of swards dominated by bracken [Pteridium aquilinum (L.) Kuhn] (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Grass and forage science 34 (1979), S. 0 
    Details
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Two methods were adopted of measuring sward output, following the prevention of bracken frond growth, with differing results. Accumulated growth estimation, corresponding to production under a system of open-range grazing, showed that asulam used for frond control had no effect on herbage yield in the year of application and large increases were observed in succeeding years compared with untreated control plots. In measuring production by sward regrowth after cutting, corresponding to intensive pasture utilization systems, asulam reduced yields in the year of treatment and increases were not observed until 2 years later. The inhibition of growth could be overcome by applying ground mineral phosphate at rates of 300 or 500 kg ha-1 before spraying but the 500 kg ha-1 rate showed no advantage over 300 kg ha-1. Applications of ground mineral phosphate after spraying had no effect on sward output.It is concluded that indigenous pasture plants in bracken-infested areas of western Scotland cease growth by mid July unless subjected to major earlier defoliation or severe soil moisture deficits and the removal of the frond canopy does not change this pattern significantly. Obtaining the full benefit of bracken clearance depends on making use of the resulting production of extra herbage and limiting as far as possible frond regrowth in treated areas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2494.1979.tb01452.x
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  • 6
    Electronic Resource
    Electronic Resource
    Solution and Solid-State Characterization of Highly Rigid, Eight-Coordinate Lanthanide(III) Complexes of a Macrocyclic Tetrabenzylphosphinate (1994)
    s.l. : American Chemical Society
    Inorganic chemistry 33 (1994), S. 4696-4706 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00099a020
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  • 7
    Electronic Resource
    Electronic Resource
    Homolytic Aromatic Arylation (1957)
    s.l. : American Chemical Society
    Chemical reviews 57 (1957), S. 123-190 
    Details
    ISSN: 1520-6890
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/cr50013a004
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  • 8
    Electronic Resource
    Electronic Resource
    REACTIONS OF ATOMS AND FREE RADICALS IN SOLUTION. XXXVII. THE CLEAVAGE OF QUATERNARY AMMONIUM SALTS WITH GRIGNARD REAGENTS (1955)
    s.l. : American Chemical Society
    The @journal of organic chemistry 20 (1955), S. 937-952 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo01125a019
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of time of spraying of glyphosate on the vegetation of an upland deep peat soil (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Grass and forage science 34 (1979), S. 0 
    Details
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The vegetation of an upland deep peat soil consisting mainly of Festuca rubra, Holcus mollis, Molinia caerulea, Juncus acutiflorus and Potentilla erecta was sprayed with 1·5 kg a.i. per ha glyphosate applied to separate plots at monthly intervals from April to August. In July of the following year, April and May applications showed no effect on sward composition while June, July and August treatments resulted in increasing proportions of mosses and bare ground. August spraying gave almost complete control of the indigenous species with the exception of F. rubra and mosses. The results are discussed in relation to the establishment of improved pastures in upland areas by surface seeding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2494.1979.tb01484.x
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  • 10
    Electronic Resource
    Electronic Resource
    Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines (2002)
    [s.l.] : Nature Publishing Group
    Nature biotechnology 20 (2002), S. 1129-1134 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We show that iterative antigen-mediated selection of B-cell lines that constitutively hypermutate their immunoglobulin V genes during culture can be exploited to generate antibodies in vitro. From Ramos, a hypermutating human B-cell line expressing IgM of unknown specificity, we derived descendants ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt752
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