Publication Date:
1996-01-26
Description:
An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Linnen, J -- Wages, J Jr -- Zhang-Keck, Z Y -- Fry, K E -- Krawczynski, K Z -- Alter, H -- Koonin, E -- Gallagher, M -- Alter, M -- Hadziyannis, S -- Karayiannis, P -- Fung, K -- Nakatsuji, Y -- Shih, J W -- Young, L -- Piatak, M Jr -- Hoover, C -- Fernandez, J -- Chen, S -- Zou, J C -- Morris, T -- Hyams, K C -- Ismay, S -- Lifson, J D -- Hess, G -- Foung, S K -- Thomas, H -- Bradley, D -- Margolis, H -- Kim, J P -- New York, N.Y. -- Science. 1996 Jan 26;271(5248):505-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genelabs Technologies, Redwood City, CA 94063, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8560265" target="_blank"〉PubMed〈/a〉
Keywords:
Acute Disease
;
Amino Acid Sequence
;
Base Sequence
;
Blood Donors
;
Blood Transfusion/*adverse effects
;
Blood-Borne Pathogens
;
Chronic Disease
;
Cloning, Molecular
;
Consensus Sequence
;
Disease Transmission, Infectious
;
Flaviviridae/genetics
;
Genome, Viral
;
Hepatitis Viruses/chemistry/*genetics/isolation & purification
;
Hepatitis, Viral, Human/epidemiology/transmission/*virology
;
Humans
;
Molecular Sequence Data
;
Polymerase Chain Reaction
;
RNA Viruses/chemistry/*genetics/isolation & purification
;
RNA, Viral/blood/genetics
;
Sequence Alignment
;
United States/epidemiology
;
Viral Proteins/chemistry/genetics
;
Viremia/epidemiology/virology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
