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  • 1
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    Genetic analysis of complex disease (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bell, D A -- Taylor, J A -- New York, N.Y. -- Science. 1997 Feb 28;275(5304):1327-8; author reply 1329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9064789" target="_blank"〉PubMed〈/a〉
    Keywords: Case-Control Studies ; Cohort Studies ; Environmental Exposure ; Family Health ; Genetic Diseases, Inborn/*genetics ; *Genetic Predisposition to Disease ; *Genetic Techniques ; Genetics, Population ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Molecular trees: a new branch of chemistry (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-02-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bell, T W -- New York, N.Y. -- Science. 1996 Feb 23;271(5252):1077-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of Nevada, Reno, NV 89557-0020, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8599080" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry, Organic/*methods ; Humans ; Molecular Structure ; Polymers/chemical synthesis/*chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Phenotypic analysis of antigen-specific T lymphocytes (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-10-04
    Description: Identification and characterization of antigen-specific T lymphocytes during the course of an immune response is tedious and indirect. To address this problem, the peptide-major histocompatability complex (MHC) ligand for a given population of T cells was multimerized to make soluble peptide-MHC tetramers. Tetramers of human lymphocyte antigen A2 that were complexed with two different human immunodeficiency virus (HIV)-derived peptides or with a peptide derived from influenza A matrix protein bound to peptide-specific cytotoxic T cells in vitro and to T cells from the blood of HIV-infected individuals. In general, tetramer binding correlated well with cytotoxicity assays. This approach should be useful in the analysis of T cells specific for infectious agents, tumors, and autoantigens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altman, J D -- Moss, P A -- Goulder, P J -- Barouch, D H -- McHeyzer-Williams, M G -- Bell, J I -- McMichael, A J -- Davis, M M -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1996 Oct 4;274(5284):94-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5428, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8810254" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Antigens, Viral/*immunology ; Base Sequence ; CD8-Positive T-Lymphocytes/immunology ; Cell Line ; Coloring Agents ; Epitopes/immunology ; Flow Cytometry ; Gene Products, gag/immunology ; HIV Seropositivity/*immunology ; HLA-A2 Antigen/*immunology ; Humans ; Molecular Sequence Data ; Peptide Fragments/*immunology ; Phenotype ; RNA-Directed DNA Polymerase/immunology ; T-Lymphocytes, Cytotoxic/*immunology ; Viral Matrix Proteins/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Detection of creatinine by a designed receptor (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-04
    Description: An artificial receptor has been designed to bind creatinine with a color change (chromogenic response) caused by proton transfer from one end of the receptor to the other. The receptor was synthesized and found to extract creatinine from water into chlorocarbon solvents. The color change in the organic layer is specific for creatinine relative to other organic solutes, and it is selective for creatinine relative to sodium, potassium, and ammonium ions. The chromogenic mechanism is revealed by x-ray crystal structures of creatinine, the free receptor, and the complex, showing "induced fit" binding resulting from electronic complementarity between host and guest.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bell, T W -- Hou, Z -- Luo, Y -- Drew, M G -- Chapoteau, E -- Czech, B P -- Kumar, A -- New York, N.Y. -- Science. 1995 Aug 4;269(5224):671-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, State University of New York, Stony Brook 11794-3400, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7624796" target="_blank"〉PubMed〈/a〉
    Keywords: Acridines/*chemical synthesis/chemistry ; Binding Sites ; Chromogenic Compounds/*chemical synthesis/chemistry ; Creatinine/*analysis/blood/chemistry ; Crystallization ; Crystallography, X-Ray ; Drug Design ; Humans ; Hydrogen/chemistry ; Hydrogen Bonding ; Naphthyridines/*chemical synthesis/chemistry ; Oxygen/chemistry ; Protons
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Sprites as Luminous Columns of Ionization Produced by Quasi-Electrostatic Thundercloud Fields (1996)
    In:  Other Sources
    Details
    Publication Date: 2019-08-17
    Description: Quasi-electrostatic (QE) fields which exist above thunderclouds after lightning discharges can lead to the formation of columnar channels of breakdown ionization and carrot-like vertical luminous structures with typical transverse dimension approximately 5-10 km spaning an altitude range from approximately 80 km to well below approximately 50 km. The carrot-like forms closely resemble those observed in sprites. Results indicate that the appearance of optical emissions can be significantly delayed in time (approx. 1-20 ms) with respect to the causative lightning discharge.
    Keywords: Geophysics
    Type: Paper 96GL00473 , Geophysical Research Letters (ISSN 0094-8534); 23; 6; 649-652
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  • 6
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    Hematite, pyroxene, and phyllosilicates on Mars: Implications from oxidized impact melt rocks from Manicouagan Crater, Quebec, Canada (1995)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Visible and near-IR reflectivity, Mossbauer, and X ray diffraction data were obtained on powders of impact melt rock from the Manicouagan Impact Crater located in Quebec, Canada. The iron mineralogy is dominated by pyroxene for the least oxidized samples and by hematite for the most oxidized samples. Phyllosilicate (smectite) contents up to 15 wt % were found in some heavily oxidized samples. Nanophase hematite and/or paramagnetic ferric iron is observed in all samples. No hydrous ferric oxides (e.g., goethite, lepidocrocite, and ferrihydrite) were detected, which implies the alteration occurred above 250 C. Oxidative alteration is thought to have occurred predominantly during late-stage crystallization and subsolidus cooling of the impact melt by invasion of oxidizing vapors and/or solutions while the impact melt rocks were still hot. The near-IR band minimum correlated with the extent of aleration (Fe(3+)/Fe(sub tot)) and ranged from approx. 1000 nm (high-Ca pyroxene) to approx. 850 nm (bulk, well-crystalline hematite) for least and most oxidized samples, respectively. Intermediate band positions (900-920 nm) are attributed to low-Ca pyroxene and/or a composite band from hematite-pyroxene assemblages. Manicouagan data are consistent with previous assignments of hematite and pyroxene to the 850 and 1000 nm bands observed in Martian reflectivity spectra. Manicouagan data also show that possible assignments for intermediate band positions (900-920 nm) in Martian spectra are pyroxene and/or hematite-pyroxene assemblages. By analogy with impact melt sheets and in agreement with observables for Mars, oxidative alteration of Martian impact melt sheets above 250 C and subsequent erosion could produce rocks and soils with variable proportions of hematite (both bulk and nanophase), pyroxene, and phyllosilicates as iron-bearing mineralogies. If this process is dominant, these phases on Mars were formed rapidly at relatively high temperatures on a sporadic basis throughout the history of the planet. The Manicouagan samples also show that this mineralogical diversity can be accomplished at constant chemical composition, which is also indicated for Mars from analyses of soil at the two Viking landing sites.
    Keywords: Geophysics
    Type: Paper-95JE01500 , MSATT; 100; E3; 5319-5328
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  • 7
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    Thermal emission measurements 2000-400 cm(exp -1) (5-25 microns) of Hawaiian palagonitic soils and their implications for Mars (1995)
    In:  CASI
    Details
    Publication Date: 2019-08-17
    Description: The thermal emission of two palagonitic soils, common visible and near infrared spectral analogs for bright soils on Mars, was measured over the wavelength range of 5 to 25 microns (2000 to 400 cm(exp -1) for several particle size separates. All spectra exhibit emissivity features due to vibrations associated with H2O and SiO. The maximum variability of emissivity is approx. = 20% in the short wavelength region (5 to 6.5 microns, 2000 to 1500 cm(exp -1)), and is more subdued, 〈 4%, at longer wavelengths. The strengths of features present in infrared spectra of Mars cannot be solely provided by emissivity variations of palagonite; some other material or mechanism must provide additional absorption(s).
    Keywords: Geophysics
    Type: Paper-94JE02448 , MSATT; 100; E3; 5309-5317
    Format: text
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