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  • 1
    Electronic Resource
    Electronic Resource
    Molecular dynamics of a hemoglobin crosslinking reaction (1996)
    New York : Wiley-Blackwell
    Biopolymers 39 (1996), S. 615-618 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: No abstract.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Uptake of phenylacetic acid by two strains of Penicillium chrysogenum (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 60 (1998), S. 310-316 
    Details
    ISSN: 0006-3592
    Keywords: Penicillium chrysogenum ; phenylacetic acid ; transport ; metabolism ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Uptake of phenylacetic acid, the side-chain precursor of benzylpenicillin, was studied in Penicillium chrysogenum Wisconsin 54-1255 and in a strain yielding high levels of penicillin. In penicillin fermentations with the high-yielding strain, 100% recovery of phenylacetic acid in benzylpenicillin was found, whereas in the Wisconsin strain only 17% of the supplied phenylacetic acid was incorporated into benzylpenicillin while the rest was metabolized. Accumulation of total phenylacetic acid-derived carbon in the cells was nonsaturable in both strains at high external concentrations of phenylacetic acid (250-3500 μM), and in the high-yielding strain at low phenylacetic acid concentrations (2.8-100 μM), indicating that phenylacetic acid enters the cells by simple diffusion, as concluded earlier for P. chrysogenum by other authors. However, at low external concentrations of phenylacetic acid saturable accumulation appeared in the Wisconsin strain. HPLC-analyses of cell extracts from the Wisconsin strain showed that phenylacetic acid was metabolized immediately after entry into the cells and different [14C]-labeled metabolites were detected in the cells. Up to approximately 50% of the accumulated phenylacetic acid was metabolized during the transport-assay period, the conversion having an impact on the uptake experiments. Nevertheless, accumulation of free unchanged phenylacetic acid in the cells showed saturation kinetics, suggesting the possible involvement of a high-affinity carrier in uptake of phenylacetic acid in P. chrysogenum Wisconsin 54-1255. At high concentrations of phenylacetic acid, contribution to uptake by this carrier is minor in comparison to simple diffusion and therefore, of no importance in the industrial production of penicillin. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 60: 310-316, 1998.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Voltammetric sensor for uranium based on the propyl gallate- modified carbon paste electrode (1995)
    Weinheim : Wiley-Blackwell
    Electroanalysis 7 (1995), S. 247-250 
    Details
    ISSN: 1040-0397
    Keywords: Uranium ; Sensor ; Remote sensing ; Field screening ; Modified electrode ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A carbon paste electrode modified with the ligand propyl gallate is introduced for preconcentration/voltammetric measurements of low levels of uranium. The resulting preconcentrating electrode offers many attractive properties for on-site sensing of uranium, including high sensitivity and selectivity, self-cleaning capability, and use of nondeaerated quiescent solutions. The response is characterized with respect to the paste composition, preconcentration period, solution and differential pulse conditions, and other variables. The sensor displays high stability, and can be used repeatedly without regeneration. When coupled to a 100-ft (30.5-m) long shielded cable, the electrode offers a remote sensing capability, as illustrated in the determination of uranium in groundwater.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140070308
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  • 4
    Electronic Resource
    Electronic Resource
    Detection of glucose at a rotating gold composite electrode by pulsed amperometric detection (1996)
    Weinheim : Wiley-Blackwell
    Electroanalysis 8 (1996), S. 443-446 
    Details
    ISSN: 1040-0397
    Keywords: Glucose ; Composite electrodes ; Pulsed amperometry ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Segregated composite electrodes mimic microelectrode ensembles. In this preliminary report, the use of a rotating gold-polychlorotri- fluoroethylene (or Kel-F, a 3M Company polymer) composite electrode in combination with pulsed amperometric detection (PAD) is described for the detection of glucose. Comparisons are made with results obtained at a solid gold disk electrode. The composite electrode exhibits a higher signal and a lower background than does the solid gold electrode. In terms of current density, the enhancement of the signal above the background is over 3-fold, similar to that observed with segregated graphite composite electrodes used in a constant potential mode. Little or no glucose signal is observed at either the solid gold or the gold composite electrode when employed in the constant potential mode. In the PAD mode, the signal is stable for periods in excess of an hour.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140080508
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  • 5
    Electronic Resource
    Electronic Resource
    Next generation risk management (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Process Safety Progress 16 (1997), S. 69-71 
    Details
    ISSN: 1066-8527
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The management of safety, quality and environmental issues covers a complex set of interrelated issues of concern to society and industry. Traditionally an engineering approach has been adopted for the management of risk; the development of technical standards, operations and requirements. Recently, industry leaders have begun to realize that real progress will be made only throgh effective risk management systems. This paper presents a few of the key requirements for improving risk management and risk analysis. By improving the way risk analysis is used for decision support, improving hazard identification exercise, while incorporating site specific properties of design, condition, operation and management into an analysis, it is possible to improve the value of current risk management techniques.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prs.680160204
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  • 6
    Electronic Resource
    Electronic Resource
    Spin-orbit and correlation effects in platinum hydride (PtH) (1998)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 68 (1998), S. 53-64 
    Details
    ISSN: 0020-7608
    Keywords: Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The low-lying electronic states of PtH were studied by all-electron one- and two-component variational calculations on the multireference CI levels. The orbital optimization is performed within a one-component formalism, whereas the further refinement of the wave functions follows two different schemes: The most demanding approach introduces spin-orbit coupling in the CI optimization step, giving a simultaneous treatment of electron correlation and spin-orbit coupling. The second, considerably less demanding approach, corresponds almost to a perturbational treatment, introducing spin-orbit coupling as a final step after the CI optimization by diagonalizing the resulting Hamiltonian matrix over CI states.   © 1998 John Wiley & Sons, Inc. Int J Quant Chem 68: 53-64, 1998
    Additional Material: 9 Tab.
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  • 7
    Electronic Resource
    Electronic Resource
    The human keratinocyte two-dimensional gel protein database (update 1995): Mapping components of signal transduction pathways (1995)
    Weinheim : Wiley-Blackwell
    Electrophoresis 16 (1995), S. 2177-2240 
    Details
    ISSN: 0173-0835
    Keywords: Two-dimensional gel protein database ; Keratinocytes ; Protein identification ; Signal transduction components ; Global cell regulation ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: The master two-dimensional (2-D) gel database of human keratinocytes currently lists 3154 cellular proteins (2224 isoelectric focusing, IEF; and 930 none-quilibrium pH gradient electrophoresis, NEPHGE), many of which correspond to post-translational modifications. 1082 polypeptides have been identified (protein name, organelle components, etc.) using a procedure or a combination of procedures that include (i) comigration with known human proteins, (ii) 2-D gel immunoblotting using specific antibodies, (iii) microsequencing of Coomassie Brilliant Blue stained proteins, (iv) mass spectrometry, (v) vaccinia virus expression of full length cDNAs, and (vi) in vitro transcription/translation of full-length cDNAs. This year, special emphasis has been given to the identification of signal transduction components by using 2-D gel immunoblotting of crude keratinocyte lysates in combination with enhanced chemoluminescence (ECL) detection. Identified proteins are listed both in alphabetical order and with increasing SSP number, together with their Mr, pI, cellular localization and credit to the investigator(s) that aided in the identification. Ultimately, the aim of the comprehensive database is to gather - through a systematic study of ekeratinocytes - qualitative and quantitative information on proteins and their genes that may allow us to identify abnormal patterns of gene expression and to pinpoint signaling pathways and components affected in various skin diseases, cancer included.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.11501601355
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  • 8
    Electronic Resource
    Electronic Resource
    Identification of proteins that are abnormally regulated in differentiated cultured human keratinocytes (1995)
    Weinheim : Wiley-Blackwell
    Electrophoresis 16 (1995), S. 2241-2248 
    Details
    ISSN: 0173-0835
    Keywords: Keratinocytes ; Differentation ; Abnormal regulation ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Comparison of the protein expression patterns of proliferating normal primary human keratinocytes plated in serum-free medium (SFKM), supplemented with epidermal growth factor (EGF) and bovine pituitary extract (BPE), and similar cultures induced to differentiate by the addition of Dulbecco's modified Eagle medium (DMEM), containing 10% fetal calf serum (FCS), revealed several known and unknown polypeptides that are abnormally regulated in the differentiated cells. Upregulated proteins included keratins (keratins 6, 10/11, 14 and 16), members of the S100 protein family psoriasin, MRP8, MRP14 and S100c), actin-binding proteins (gelsolin and tropomyosin 9220), annexins (annexins IV and VIII), hsp28, the fatty acid binding protein 5 (FABP5), the squamous cell carcinoma (SCC) antigen, members of the 14-3-3 family, involucrin, E-cadherin, cystatin A, desmoglein and integrins α2 and β1, as well as several proteins of as yet unknown identity. The highest upregulated proteins corresponded to psoriasin (124.0 times), MRP8 (42.4 times), MRP14 (14.9 times), tropomyosin 9220 (11.5 times), involucrin (11.1 times), and FABP5 (9.1 times). FABP5, hsp28, and tropomyosin 9220 were also highly upregulated in quiescent keratinocytes indicating that their increased levels in the differentiated cell may be due to loss of proliferative activity. Highly downregulated proteins included PAI-2, tropomyosins 9213, 9121 and 9122, keratin 5, calnexin, 14-3-3 beta and eta, nucleoside diphosphate kinase A, Rho GDIs, hsp60, hnRNPs H and C2, α-enolase, eIF-4D, thioredoxin, annexins III and V, moesin, nucleolar protein B23, GST π and PCNA/cyclin. Both the high expression of keratin 6 and 16 - which are markers for an alternative pathway of keratinocyte differentiation - as well as the extremely high upregulation of some members of the S100 protein family indicate that the cells have differentiated via an abnormal pathway.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.11501601356
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  • 9
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    Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13 (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-04-26
    Description: Hox genes regulate patterning during limb development. It is believed that they function in the determination of the timing and extent of local growth rates. Here, it is demonstrated that synpolydactyly, an inherited human abnormality of the hands and feet, is caused by expansions of a polyalanine stretch in the amino-terminal region of HOXD13. The homozygous phenotype includes the transformation of metacarpal and metatarsal bones to short carpal- and tarsal-like bones. The mutations identify the polyalanine stretch outside of the DNA binding domain of HOXD13 as a region necessary for proper protein function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muragaki, Y -- Mundlos, S -- Upton, J -- Olsen, B R -- AR36819/AR/NIAMS NIH HHS/ -- AR36820/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Apr 26;272(5261):548-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8614804" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; Chromosome Mapping ; Chromosomes, Human, Pair 2 ; Cloning, Molecular ; Female ; Fingers/*abnormalities/embryology ; *Genes, Homeobox ; Genetic Linkage ; Homeodomain Proteins/chemistry/*genetics/physiology ; Humans ; Male ; Molecular Sequence Data ; Morphogenesis ; Multigene Family ; Mutation ; Pedigree ; Peptides/chemistry ; Polydactyly/embryology/*genetics/radiography ; Polymerase Chain Reaction ; Syndactyly/embryology/*genetics/radiography ; Toes/*abnormalities/embryology ; *Transcription Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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