ISSN:
1572-879X
Keywords:
enantioselective hydrogenation
;
supercritical fluids
;
ethyl pyruvate
;
cinchonidine
;
Pt/alumina
;
CO-poisoning
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The enantioselective hydrogenation of ethyl pyruvate to (R)-ethyl lactate has been studied using gases under supercritical conditions as solvents. The catalyst was a 5 wt% Pt/alumina modified with cinchonidine. In supercritical ethane the reaction time could be reduced by a factor of 3.5 compared to toluene under similar conditions, without any loss in enantioselectivity. A further advantage of ethane is that the enantioselectivity remains high even at high catalyst/reactant ratio, which is interesting in view of a possible application of a continuous fixed-bed reactor for this reaction. A strong catalyst deactivation was observed in supercritical CO2, which is due to the reduction of CO2 on Pt as indicated by FTIR.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00808315
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