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  • far-infrared laser  (2)
  • thin films  (2)
  • CD3OH  (1)
  • CoMFA  (1)
  • 1995-1999  (6)
Collection
Keywords
Publisher
Years
  • 1995-1999  (6)
Year
  • 1
    Electronic Resource
    Electronic Resource
    3D-QSAR Analysis and Molecular Modeling Investigations of Piritrexim and Analogous (1997)
    Springer
    Journal of molecular modeling 3 (1997), S. 338-346 
    Details
    ISSN: 0948-5023
    Keywords: Keywords: Free-Wilson-analysis ; PLS ; genetic algorithm ; CoMFA ; piritrexim analogous
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Quantitative structure-activity relationships for piritrexim and analogues acting as inhibitors of tumour cell growth have been derived. First the Free-Wilson-method was used on a homologous training set of eight derivatives. The selection of variables important for the biological activity of the compounds was carried out with different multivariate methods as multiple linear regression, the partial least squares method und a genetic algorithm. The derivation of three-dimensional structure activity relationships started with a systematic conformational analysis of all compounds. For the conformations having minimal energy and being in agreement with the crystal structure of piritrexim charges were calculated with the AM1 hamiltonian. For the superimposition of the derivatives two methods were used: maximal similarity of the common substructure or of the molecular fields. A Comparative Molecular Field Analysis with steric and electrostastic fields identified regions important for the activity of the studied compounds independent of the chosen alignment and also correctly predicted the activity of two nonhomologous compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s008940050048
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  • 2
    Electronic Resource
    Electronic Resource
    Encapsulation of Proteins in Bulk and Thin Film Sol-Gel Matrices (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 629-634 
    Details
    ISSN: 1573-4846
    Keywords: protein encapsulation ; absorption spectroscopy ; thin films ; cytochrome c
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract This paper considers the nature of the interactions between the sol-gel derived inorganic matrix and a specific biomolecule, cytochrome c. Optical absorption and impedance spectroscopies are used to characterize the influence of synthesis conditions on the protein's stability and conformation within the silica matrix. In some instances, encapsulation within the sol-gel matrix provides stabilization. For example, protein denaturation is reversible and aggregation is prevented. Moreover, the drying process does not negatively affect the protein; it is possible to regenerate the aged gel state by rehydration. The flexibility of the sol-gel process enables high quality cytochrome c-doped SiO2 thin films to be prepared. These films possess the characteristic reactivity and chemical function of cytochrome c in solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018316108875
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  • 3
    Electronic Resource
    Electronic Resource
    Encapsulation of proteins in bulk and thin film sol-gel matrices (1997)
    Springer
    Journal of sol gel science and technology 8 (1997), S. 629-634 
    Details
    ISSN: 1573-4846
    Keywords: protein encapsulation ; absorption spectroscopy ; thin films ; cytochrome c
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract This paper considers the nature of the interactions between the sol-gel derived inorganic matrix and a specific biomolecule, cytochrome c. Optical absorption and impedance spectroscopies are used to characterize the influence of synthesis conditions on the protein’s stability and conformation within the silica matrix. In some instances, encapsulation within the sol-gel matrix provides stabilization. For example, protein denaturation is reversible and aggregation is prevented. Moreover, the drying process does not negatively affect the protein; it is possible to regenerate the aged gel state by rehydration. The flexibility of the sol-gel process enables high quality cytochrome c-doped SiO2 thin films to be prepared. These films possess the characteristic reactivity and chemical function of cytochrome c in solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02436913
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  • 4
    Electronic Resource
    Electronic Resource
    New FIR Laser Lines from CD3OH (1998)
    Springer
    International journal of infrared and millimeter waves 19 (1998), S. 1627-1631 
    Details
    ISSN: 1572-9559
    Keywords: Far-Infrared ; Methanol ; CD3OH ; Optically-Pumped Laser ; Laser
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Fourteen new optically pumped far-infrared (FIR) laser lines in the range 46.8 μm to 172.6 μm were discovered in optically pumped CD3OH. The pump sources include both the CO2 laser and the N2O laser. Two theoretically predicted laser lines were observed in this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1021758925265
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  • 5
    Electronic Resource
    Electronic Resource
    Laser Lines and Frequency Measurements of Fully Deuterated Isotopomers of Methanol (1998)
    Springer
    International journal of infrared and millimeter waves 19 (1998), S. 465-473 
    Details
    ISSN: 1572-9559
    Keywords: 12CD3OD ; 13CD3OD ; fully deuterated isotopomers ; new laser lines ; far-infrared laser ; frequency measurement ; CO2 laser pump
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Fully deuterated isotopomers of methanol (12CD3OD and 13CD3OD) were optically pumped with a CO2 laser. Five new far-infrared laser lines were discovered in 12CD3OD and 25 in 13CD3OD in the range 43.697 to 719.426 μm. The frequencies of these new and some previously reported laser lines, the pump offset, the relative polarization, the relative intensity, and the optimum pressure of operation were measured.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022511827416
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  • 6
    Electronic Resource
    Electronic Resource
    New Far-Infrared Laser Lines and Frequency Measurements of Acetaldehyde and Vinyl Fluoride (1998)
    Springer
    International journal of infrared and millimeter waves 19 (1998), S. 719-726 
    Details
    ISSN: 1572-9559
    Keywords: far-infrared laser ; frequency measurement ; acetaldehyde (CH3CHO) ; vinyl fluoride (CH2CHF) ; cw CO2 laser ; new lines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Eight far-infrared laser lines have been obtained by optically pumping acetaldehyde (CH3CHO) and nine by pumping vinyl fluoride (CH2CHF) with a cw CO2 laser. The far-infrared laser structure used a metal-dielectric waveguide cavity. This is the first reported observation of four of the laser lines in acetaldehyde. In this work, we measure the frequency, optimum pressure of operation, relative intensity, relative polarization, and pump offset from CO2 laser-line center.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022646225018
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