ISSN:
1420-9071
Keywords:
Antiviral activity
;
7,7′-dichlorohypericin
;
5,7-dichloroemodin
;
hypericin
;
anthraquinones
;
bianthrones
;
lichen
;
Nephroma laevigatum
;
Heterodermia obscurata
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The antiviral activities of some naturally occurring anthraquinones bianthrones, and hypericin derivatives were compared by the end-point CPE (viral cytopathic effects) method and plaque assays. Under optimal conditions of exposure to light, hypericin, 7,7′-dichlorohypericin and 5,7-dichloroemodin exhibited strong inhibitory activity against HSV-1 (herpes simplex virus type 1) in both assays. Partial inactivation of the virus was shown by emodin, 7-chloroemodin and 7-chloro-1-O-methylemodin; the bianthrones and other anthraquinones were found to be inactive. Antiviral activity appeared to be, positively correlated with increasing substitution of chlorine in the anthraquinone structure. In the absence of light, only hypericin and 7,7′-dichlorohypericin displayed detectable activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01923366
Permalink
