Publication Date:
1999-06-26
Description:
Segmentation of the hindbrain and branchial region is a conserved feature of head development, involving the nested expression of Hox genes. Although it is presumed that vertebrate Hox genes function as segment identifiers, responsible for mediating registration between elements of diverse embryonic origin, this assumption has remained untested. To assess this, retroviral misexpression was combined with orthotopic grafting in chick embryos to generate a mismatch in Hox coding between a specific rhombomere and its corresponding branchial arch. Rhombomere-restricted misexpression of a single gene, Hoxb1, resulted in the homeotic transformation of the rhombomere, revealed by reorganization of motor axon projections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bell, E -- Wingate, R J -- Lumsden, A -- N01-HD-7-3263/HD/NICHD NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1999 Jun 25;284(5423):2168-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Neurobiology, King's College London, Guy's Hospital, London SE1 9RT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10381880" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Axons/physiology
;
Branchial Region/*embryology/innervation/metabolism
;
Cell Differentiation
;
Cell Movement
;
Chick Embryo
;
Cloning, Molecular
;
DNA-Binding Proteins/genetics
;
GATA2 Transcription Factor
;
*Gene Expression Regulation, Developmental
;
*Genes, Homeobox
;
Genetic Vectors
;
Homeodomain Proteins/*genetics/physiology
;
Membrane Glycoproteins/genetics
;
Motor Neurons/cytology/physiology
;
Rhombencephalon/*embryology/metabolism/transplantation
;
Transcription Factors/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
