Publication Date:
1998-02-07
Description:
The possibility that membrane fusion events in the postsynaptic cell may be required for the change in synaptic strength resulting from long-term potentiation (LTP) was examined. Introducing substances into the postsynaptic cell that block membrane fusion at a number of different steps reduced LTP. Introducing SNAP, a protein that promotes membrane fusion, into cells enhanced synaptic transmission, and this enhancement was significantly less when generated in synapses that expressed LTP. Thus, postsynaptic fusion events, which could be involved either in retrograde signaling or in regulating postsynaptic receptor function or both, contribute to LTP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lledo, P M -- Zhang, X -- Sudhof, T C -- Malenka, R C -- Nicoll, R A -- New York, N.Y. -- Science. 1998 Jan 16;279(5349):399-403.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9430593" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Botulinum Toxins/pharmacology
;
Carrier Proteins/metabolism/pharmacology
;
Ethylmaleimide/pharmacology
;
Excitatory Postsynaptic Potentials
;
Exocytosis
;
Guinea Pigs
;
Hippocampus/drug effects/*physiology
;
In Vitro Techniques
;
*Long-Term Potentiation/drug effects
;
*Membrane Fusion
;
Membrane Proteins/metabolism/pharmacology
;
Molecular Sequence Data
;
N-Ethylmaleimide-Sensitive Proteins
;
Patch-Clamp Techniques
;
Peptides/pharmacology
;
Pyramidal Cells/physiology
;
Receptors, N-Methyl-D-Aspartate/physiology
;
Recombinant Proteins/pharmacology
;
Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
;
Synaptic Membranes/*physiology
;
Synaptic Transmission
;
*Vesicular Transport Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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