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  • 1
    Electronic Resource
    Electronic Resource
    Optimization of the synthesis of peptide combinatorial libraries using a one-pot method (1997)
    Springer
    Molecular diversity 2 (1997), S. 147-155 
    Details
    ISSN: 1573-501X
    Keywords: Peptide libraries ; Combinatorial ; Protein sequencing ; Mass spectrometry ; Continuous flow ; HATU
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Conditions for the synthesis of synthetic peptide combinatorial libraries (SPCLs) from mixtures of amino acids were explored. In a one-pot synthesis, the effect of the starting concentrations of amino acids on the resulting library composition was studied, and the optimum balance of amino acids was determined. Protein sequencing, MALDI-TOF, and amino acid analysis were used for the evaluation of the libraries, and their relative merits are discussed. The effects of continuous-flow automated synthesis instrumentation in conjunction with polyethylene glycol-polystyrene (PEG-PS) graft supports and various cleavage cocktails on the successful synthesis of SPCLs were examined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01682202
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  • 2
    Electronic Resource
    Electronic Resource
    Separation of the enantiomers of amino acid esters as benzophenone imine derivatives on polysaccharide-derived chiral stationary phases (1999)
    Springer
    Chromatographia 49 (1999), S. 61-64 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Chiral stationary phases ; Benzophenone imine derivatives ; Amino acid esters ; Enantiomer separation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The liquid-chromatographic separation of the enantiomers of amino acid esters as benzophenone Schiff-base derivatives on polysaccharide-derived chiral stationary phases (CSPs) is described. The performance of Chiralcel OF was superior to that of the other CSPs for resolution of benzophenone imine derivatives of amino acid ethyl and methyl esters. The enantiomers of most of the amino acid esters examined as their benzophenone imine derivatives were resolved to baseline on Chiralcel OF. The L-(−) enantiomers of all the analytes were preferentially retained on Chiralcel OF. The resolution of several imine derivatives of amino acid esters was investigated, as was the effect of eluent composition on the resolution of amino acid ethyl esters as their benzophenone imine derivatives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02467188
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    Paper (German National Licenses)
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