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  • Springer  (373)
  • Wiley-Blackwell  (40)
  • Molecular Diversity Preservation International
  • 1995-1999  (413)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Antioxidant survey to assess antagonism to redox stress using a prokaryotic and an eukaryotic system (1996)
    Springer
    Cellular and molecular life sciences 52 (1996), S. 597-599 
    Details
    ISSN: 1420-9071
    Keywords: Glutathione ; free radicals ; antioxidants ; oxidant stressors ; buthionine ; menadione
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Using a prokaryote (Escherichia coli) and a metazoa-resembling eukaryote (Ochromonas danica), we surveyed antioxidants which might overcome redox stress imposed by menadione sodium bisulphite (MD) and buthionine sulphoximine (BSO). BSO oxidant stress was evident only inO. danica; MD oxidant stress was evident in both organisms. Glutathione, its precursors, e.g. cysteine, homocysteine, and 2-oxo-4-thiazolidine carboxylic acid, and red blood cells, emerged as prime antioxidants for relieving BSO and MD oxidant stress. BSO and MD oxidant activity and antioxidant-annulling effect inO. danica were judged comparable to those found in animal cells whereas the resultsE. coli were not entirely equivalent. TheO. danica system emerged as a practical, rapid, and useful system for pinpointing oxidant stressors and antioxidants, and shows promise for studies with mammalian systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01969736
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  • 2
    Electronic Resource
    Electronic Resource
    Growth hormone receptor expression in the nucleus and cytoplasm of normal and neoplastic cells (1998)
    Springer
    Histochemistry and cell biology 109 (1998), S. 141-159 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Growth hormone (GH) exerts its regulatory functions in controlling metabolism, balanced growth and differentiated cell expression by acting on specific receptors which trigger a phosphorylation cascade, resulting in the modulation of numerous signalling pathways dictating gene expression. A panel of five monoclonal antibodies was used in mapping the presence and somatic distribution of the GH receptor by immunohistochemistry in normal and neoplastic tissues and cultured cells of human, rat and rabbit origin. A wide distribution of the receptor was observed in many cell types. Not all cells expressing cytoplasmic GH receptors displayed nuclear immunoreactivity. In general, the relative proportion of positive cells and intensity of staining was higher in neoplastic cells than in normal tissue cells. Immunoreactivity showed subcellular localisation of the GH receptor in cell membranes and was predominantly cytoplasmic, but strong nuclear immunoreaction was also apparent in many instances. Intense immunoreactivity was also observed in the cellular Golgi area of established cell lines and cultured tissue-derived cells in exponential growth phase, indicating cells are capable of GH receptor synthesis. The presence of intracellular GH receptor, previously documented in normal tissues of mostly animal origin, is the result of endoplasmic reticulum and Golgi localisation. Heterogeneity of immunoreactivity was found in normal and neoplastic tissue with a variable range of positive cells. The nuclear localisation of immunoreactivity is the result of nuclear GH receptor/binding protein, identically to the cytosolic and plasma GH-binding protein, using a panel of five monoclonal antibodies against the GH receptor extracellular region. The expression of GH receptors, not only on small proliferating tumour cells such as lymphocytes, but also on well differentiated cells including keratinocytes, suggests that GH is necessary not only for differentiation of progenitor cells, but also for their subsequent clonal expansion, differentiation and maintenance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004180050212
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  • 3
    Electronic Resource
    Electronic Resource
    Crystal structure of Escherichia coli manganese superoxide dismutase at 2.1-Å resolution (1998)
    Springer
    JBIC 3 (1998), S. 161-171 
    Details
    ISSN: 1432-1327
    Keywords: Key words Superoxide dismutase ; Manganese enzyme ; Crystal structure ; Metalloprotein ; DNA binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract  The three-dimensional structure of the manganese-dependent superoxide dismutase (MnSOD) from Escherichia coli has been determined by X-ray crystallography at 2.1 Å resolution. The protein crystallizes with two homodimers in the asymmetric unit, and a model comprising 6528 protein atoms (residues 1–205 of all four monomers), four manganese ions and 415 water molecules has been refined to an R factor of 0.188 (R free 0.218). The structure shows a high degree of similarity with other MnSOD and FeSOD enzymes. The Mn centres are 5-coordinate, trigonal bipyramidal, with His26 and a solvent molecule, probably a hydroxide ion, as apical ligands, and His81, Asp167 and His171 as equatorial ligands. The coordinated solvent molecule is linked to a network of hydrogen bonds involving the non-coordinated carboxylate oxygen of Asp167 and a conserved glutamine residue, Gln146. The MnSOD dimer is notable for the way in which the two active sites are interconnected and a "bridge" comprising His171 of one monomer and Glu170 of the other offers a route for inter-site communication. Comparison of E. coli MnSOD and FeSOD (a) reveals some differences in the dimer interface, (b) yields no obvious explanation for their metal specificities, and (c) provides a structural basis for differences in DNA binding, where for MnSOD the groove formed by dimerization is complementary in charge and surface contour to B-DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007750050217
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  • 4
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    Antioxidant survey to assess antagonism to redox stress using a prokaryotic and an eukaryotic system (1996)
    Springer
    Details
    Publication Date: 1996-06-01
    Print ISSN: 0014-4754
    Topics: Biology , Medicine
    Published by Springer
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    PAPER CURRENT
  • 5
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    Growth hormone receptor expression in the nucleus and cytoplasm of normal and neoplastic cells (1998)
    Springer
    Details
    Publication Date: 1998-01-28
    Print ISSN: 0018-2222
    Electronic ISSN: 1432-119X
    Topics: Biology , Medicine
    Published by Springer
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    PAPER CURRENT
  • 6
    Electronic Resource
    Electronic Resource
    Microbial process for preparation of glucuronides of raloxifene (1999)
    Springer
    Journal of industrial microbiology and biotechnology 23 (1999), S. 194-197 
    Details
    ISSN: 1476-5535
    Keywords: Keywords: raloxifene; glucuronidation; Streptomyces sp NRRL 21489
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Raloxifene, also known as Evista®, has recently been approved for the prevention of osteoporosis. Three glucuronidated compounds: raloxifene-6-glucuronide, raloxifene-27-glucuronide, and raloxifene-6,27-diglucuronide are known metabolites of raloxifene in man. Reference standards of the three glucuronides were needed for clinical trials. Although chemical routes exist to make the two mono-glucuronides, these routes were unable to provide material to meet the needs of clinical trial standards. No chemical route existed to synthesize the di-glucuronide. A bioconversion process using the microorganism Streptomyces sp NRRL 21489 was identified and scaled up. The biotranformation products were prepared in a tank fermentation, purified, and characterized by UV, LC/MS and NMR spectroscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/sj.jim.2900716
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  • 7
    Electronic Resource
    Electronic Resource
    Hybrid GPS + GLONASS (1999)
    Springer
    GPS solutions 3 (1999), S. 32-41 
    Details
    ISSN: 1521-1886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: The hybridization of GPS with GLONASS has formed a first stage in GNSS development. We examine the performance of the hybrid system in the position domain for both code and carrier phase cases. Several major differences exist between GPS and GLONASS; most significant is GLONASS's signal frequency diversity, which can lead to measurement bias, particularly so when a pair of receivers are operating at different temperatures. Unless signal frequency diversity is addressed either on-receiver or at the data processing stage, positioning errors can occur at the centimeter level. We outline the difficulties of combining observations from the two systems and discuss how these may be overcome. © 1999 John Wiley & Sons, Inc.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00012777
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  • 8
    Electronic Resource
    Electronic Resource
    Crystal structure of [WBr2(CO)(PPh2Cy)2(η2-MeC2Me)]·CH2Cl2 (Cy = cyclohexyl) (1999)
    Springer
    Journal of chemical crystallography 29 (1999), S. 809-812 
    Details
    ISSN: 1572-8854
    Keywords: tungsten(II) ; dibromo ; carbonyl ; diphenylcyclohexylphosphine ; but-2-yne ; crystal structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract [WBr2(Co)(PPh2Cy)2(η2-MeC2Me)]·CH2Cl2 (Cy = cyclohexyl) crystallizes in the monoclinic space group, P21/n, with a = 10.606(12), b = 23.11(3), c = 18.19(2) Å, β = 106.070(10) Dcalc = 1.610g cm−3 for Z = 4. The tungsten coordination geometry can best be considered as a distorted octahedron, with the but-2-yne ligand occupying one coordination site, which has a trans-Br(2) group. The equatorial plane is made up of trans-PPh2Cy groups, with the bromo and carbonyl ligands occupying the other two sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009599821025
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  • 9
    Electronic Resource
    Electronic Resource
    Synthesis and crystal structure of [WI(CO)(cis-dppen) η2-MeC2Me)2]I·CH2Cl2 {cis-dppen = bis(diphenylphosphino)ethene} (1999)
    Springer
    Journal of chemical crystallography 29 (1999), S. 907-911 
    Details
    ISSN: 1572-8854
    Keywords: tungsten(II) ; Iodo ; carbonyl ; cis-bis(diphenylphosphino)ethene ; but-2-yne ; cationic ; crystal structure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The complex [WI(CO)(cis-dppen)(η2-MeC2Me)2]I·CH2Cl2(1) is prepared as a by-product from the reaction of equimolar quantities of [WI2(CO)(NCMe)(η2-MeC2Me)2] and cisdppen {dppen = bis(diphenylphosphino)ethene}. Complex 1, [WI(CO)(cis-dppen)(η2-MeC2Me)2]I·CH2Cl2 crystallizes in the triclinic space group $${\text{P}}\bar 1$$ with a = 11.189(13), b = 12.331(14), c = 15.395(17) Å, α = 83.61(1), β = 86.06(1), γ = 64.48(1)°, U = 1904 Å3, and Z = 2. The metal environment in the cation can best be considered as a distorted octahedron with the two but-2-yne groups taking up individual sites trans to phosphorus atoms of the dppen ligand. The coordination sphere is completed by mutually trans-carbonyl and iodide groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009526012075
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  • 10
    Electronic Resource
    Electronic Resource
    Learning Orientation, Market Orientation, and Innovation: Integrating and Extending Models of Organizational Performance (1999)
    Springer
    Journal of market-focused management 4 (1999), S. 295-308 
    Details
    ISSN: 1572-8846
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract Recent studies have demonstrated effects of learning orientation or market orientation on innovation-driven organizational performance. While these studies have enhanced our understanding of innovation processes in the firm, they have been unable to determine the relative contribution of learning orientation and market orientation to innovation. The integration of these two fundamental strategic orientations in this research enables such an assessment. The model in this research also measures the degree to which market orientation and learning orientation influence organizational performance, independent of their effect on product innovation. The most notable finding is the potential preeminence of learning orientation over market orientation. The implications are of critical importance to marketers because they provide insights into the type of organizational culture that is associated with high levels of performance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009830402395
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