ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Sharpless epoxidation of (E)-1-(trimethylsilyl)[1-2H1]oct-1-en-3-o1 (3a) yielded (1S,2S,3S)- and (1R,2R,3R)-1-(trimethylsilyl)-1,2-epoxy[1-2H1]octan-3-ols (4a and 4b, resp.) which were converted in three steps into (S)- and (R)-fluoro[ 2H1]acetic acid (7a and 7b, resp.) in good yields. Their high isotopic and optical purity was established by 1H- and 19F-NMR, mass, and circular-dichroism spectroscopy.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19960790411
Permalink