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  • Springer  (351)
  • American Society of Hematology  (21)
  • 1995-1999  (372)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Immunogenetics 42 (1995), S. 233-243 
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract An evolutionary analysis of self peptides reported to be bound by HLA class I molecules showed that these peptides are largely derived from proteins that have been highly conserved in the history of mammals. These proteins also often have universal tissue expression and have a higher than average frequency of highly hydrophilic residues. The peptides themselves are generally still more highly conserved than the source proteins and have a higher frequency of highly hydrophobic residues, evidently often derived from conserved hydrophobic cores of the source proteins. These results suggest that the mechanism by which peptides are derived for MHC presentation may preferentially select peptides from conserved protein regions. In the case of parasite-derived peptides, such a mechanism would be adaptive in that it would reduce the likelihood of escape mutants.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Pharmacy world & science 21 (1999), S. 251-255 
    ISSN: 1573-739X
    Keywords: Abuse ; Misuse ; Non‐prescription medicines ; Over‐the‐counter products ; Pharmacist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Aim: To investigate the abuse of non‐prescription (over‐the‐counter; OTC) products in Northern Ireland. Method: A structured questionnaire covering various aspects of OTC drug abuse was mailed to all 509 community pharmacies in Northern Ireland. Results: 253 responses were received (response rate 49.7%) after two mailings. Pharmacists named 112 OTC products they perceived were being abused in Northern Ireland. These were classified into 8 groups, with opioids, antihistamines and laxatives the most frequently reported. The frequency of abuse of all product groups was perceived to be either increasing or static. The number of clients suspected of abuse over a three‐month period ranged from 0 to 700 (median=10, mode=6) with 55% being regular customers. Pharmacists employed several methods to limit patient access to products of abuse. The most common technique was to keep the product out of sight. Others included additional client questioning, providing advice and limiting the quantity of product sold. The majority of respondents agreed their role could be extended to include other methods of dealing with abusers, including participation in harm‐reduction programmes to wean abusers off products. Geographical region and location of pharmacy were not significant factors in the abuse of OTC products. Conclusions: Pharmacists in Northern Ireland perceive abuse and misuse of OTC products to be occurring in practice. Current methods employed for dealing with it are inadequate. Research into methods of effectively dealing with OTC abuse/misuse is required and has commenced on the basis of these findings.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 1995-03-01
    Print ISSN: 0093-7711
    Electronic ISSN: 1432-1211
    Topics: Biology , Medicine
    Published by Springer
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  • 5
    Publication Date: 1995-08-01
    Print ISSN: 0093-7711
    Electronic ISSN: 1432-1211
    Topics: Biology , Medicine
    Published by Springer
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  • 6
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We present estimates of possible data on spin-dependent asymmetries in inclusive scattering of high energy polarized electrons by high energy polarized protons at HERA with their statistical errors and discuss systematic errors. We show that these data will provide important information on the low-x behavior of the polarized structure function $g_1$ , and will reduce the uncertainty in the determination of the first moment of the polarized gluon distribution $\Delta g(x,Q^2)$ obtained from the QCD analysis of $g_1$ in NLO. Furthermore, using asymmetries for di-jet events from a polarized HERA would substantially reduce the uncertainty in the shape of $\Delta g(x,Q^2)$ . Use of the information on $\Delta g(x,Q^2)$ from the di-jet analysis in conjunction with the NLO QCD analysis of $g_1$ will provide an accurate determination of $\Delta g(x,Q^2)$ and its first moment.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Entomologia experimentalis et applicata 85 (1997), S. 281-283 
    ISSN: 1570-7458
    Keywords: Plutella xylostella ; diamondback moth ; Plutellidae ; oviposition ; Brassica oleracea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1572-8099
    Keywords: Flame extinguishment ; thermal mechanisms ; flame quenching ; theory ; heat-absorption sinks ; scaling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Abstract In a continuing study of flame extinguishment,1,2,3,4 we report on scaling studies for dry chemicals on larger heptane diffusion flames (0.29 m2 and 2.32 m2 pans). We demonstrate again that small particle sizes extinguish most effectively. Extinguishment is related to heat absorption by decomposing or vaporizing particles. We show that the limiting particle size for each dry chemical—that is, the maximum size which completely decomposes or vaporizes in the flame—is independent of flame size for the systems studied. We broaden and apply the concept of latent or maximum effectiveness2,3 to pan fires of all sizes. Finally, we describe and characterize an aerodynamic effect in the transport of powders, where large particles with their higher momentum entrain and drag smaller, more effective particles into the flame. We also show that extinction curves, involving the ratio of real-to-latent extinction weight and the proportion of small to large particles, have predictable shapes and predictable quantitative levels for most dry chemicals. We have developed the real-to-latent concept along with scaling equations for agent mixtures and for a wide spectrum of agents and particle sizes.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Entomologia experimentalis et applicata 93 (1999), S. 51-61 
    ISSN: 1570-7458
    Keywords: Metarhizium anisopliae ; Atta sexdens rubropilosa ; leaf-cutting ants ; biological control ; social homeostasis ; entomopathogenic fungus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract There is growing interest in the use of entomopathogenic organisms to control leaf-cutting ants (Hymenoptera: Formicidae: Attini). However, the way leaf-cutting ants react as a colony to biohazards is poorly understood. We investigated the effects of Metarhizium anisopliae (Metschnikoff) (Deuteromycotina: Hyphomycetes) applied to the foraging arenas of mini-nests (queenless sub-colonies) of the leaf-cutting ant Atta sexdens rubropilosa (Forel). Dry spores were applied either alone or mixed with citrus powder, at 0.5 g or 0.05 g per mini-nest. The spores were removed four days after application, and all dead ants removed every three days. Ant numbers near the Metarhizium increased as the ants attempted to clean up the biohazard. The ants attempted to place the spores in piles, which they then covered over with other material. They were able to deal with the low doses in this way, but the high doses overwhelmed them. All treated mini-nests suffered increased ant mortality during the first ten days after application. This mortality was particularly high in the media worker caste which had played the major role in attempting to clean up the spores. Foraging activity decreased, as did the health of the fungus gardens. The mini-nests exposed to the low dose of spores mixed with citrus powder then recovered fully. The health of the other treated mini-nests declined gradually until around 26 days after application, when they began deteriorating sharply. However, the decline of these mini-nests after day 26 was not due directly to the pathogenic action of the Metarhizium, nor to the initial ant mortality it had caused. The results suggest that the social stress caused by even such a short-lived Metarhizium epizootic was sufficient to cause the decline and ultimate death of the mini-nests. This has important implications for the control of leaf-cutting ants. It also demonstrates how important the social homeostasis of the colony is to leaf-cutting ants.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1572-8099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Abstract We investigated the extinguishing properties of multipurpose dry chemicals using openregime cribs of two sizes. One measured 20.3 by 20.3 by 15.2 cm, and the other 50.8 by 50.8 by 38 cm. A crib fire, which has both flaming and smoldering contributions, is primarily extinguished when the burning surfaces are covered or smothered by a gas phase of the original multipurpose agent or a product of the agent's decomposition. The overall effectiveness of each dry chemical depends on its particle size, the degree of its decomposition and/or vaporization, and the openness of the crib. All particles of an agent below a unique limiting size completely decompose and/or vaporize in the crib fire and have the same extinguishing effectiveness. Particles above the limit have no measurable effectiveness. Scaling is considered on the basis of the minimum extinction weight per unit of exposed wood surface.
    Type of Medium: Electronic Resource
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