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  • Chemistry  (2)
  • 53C05  (1)
  • Analgesia  (1)
  • Bayes estimators  (1)
  • Springer  (3)
  • Wiley-Blackwell  (2)
  • American Chemical Society
  • Hindawi
  • Public Library of Science
  • 1995-1999  (5)
Collection
Publisher
  • Springer  (3)
  • Wiley-Blackwell  (2)
  • American Chemical Society
  • Hindawi
  • Public Library of Science
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of the Institute of Statistical Mathematics 50 (1998), S. 715-727 
    ISSN: 1572-9052
    Keywords: Admissibility of estimators ; Bayes estimators ; best equivariant estimator ; Langevin distribution ; mean direction vector ; Stein effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The circular normal distribution, CN(μ, κ), plays a role for angular data comparable to that of a normal distribution for linear data. We establish that for the curved and for the regular exponential family situations arising when κ is known, and unknown respectively, the MLE $$\widehat\mu$$ of the mean direction μ is the best equivariant estimator. These results are generalized for the MLE $$\widehat{\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\thicksim}$}}{\mu } }$$ of the mean direction vector $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\thicksim}$}}{\mu } = (\mu _1 , \ldots ,\mu _p )'$$ in the simultaneous estimation problem with independent CN(μ $$_i$$ , ϰ), i = 1,..., p, populations. We further observe that $$\widehat{\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\thicksim}$}}{\mu } }$$ is admissible both when κ is known or unknown. Thus unlike the normal theory, Stein effect does not hold for the circular normal case. This result is generalized for the simultaneous estimation problem with directional data in q-dimensional hyperspheres following independent Langevin distributions, L( $$L(\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\thicksim}$}}{\mu } _i ,\kappa ),i = 1, \ldots ,p$$ .
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Letters in mathematical physics 34 (1995), S. 135-147 
    ISSN: 1573-0530
    Keywords: 53C05 ; 58D27 ; 81T13
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract A natural gauge-invariant 2-form is introduced on the space of connections over a compact oriented surface with boundary. It is shown that this 2-form descends to the moduli space of flat connections, under a group of based gauge transformations. An explicit expression (in terms of holonomy variations) is given for the resulting 2-form, and it is related to the symplectic structure of the extended moduli space introduced by L. C. Jeffrey.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1041
    Keywords: Key words Nimesulide ; Topical gel ; Analgesia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The present study was conducted to compare the analgesic efficacy of a new topical gel formulation of nimesulide (10 mg of pure drug) with that of placebo, diclofenac and piroxicam gels (10 mg of pure drug) in three parallel groups in a double-blinded, randomized fashion with vehicle placebo. The analgesic activity of nimesulide was subsequently correlated with its pharmacokinetic profile. Methods: The drugs were applied on a fixed marked area on the skin of the right forearm. Pain stimulus was administered using a modification of the Hollander method, before and at 15, 30, 60, 120 min and 240 min post-treatment. The pain experienced by the subjects was ranked separately on the visual analogue scale (VAS) and the ten-point category scale. Antinociception induced by the treatments was evaluated through the placebo-related ratings (PRR) and total pain relief (TOTPAR) analysis. The plasma concentration of nimesulide was estimated using high-performance liquid chromatography (HPLC). Results: Nimesulide exhibited better efficacy than diclofenac, piroxicam and placebo. It demonstrated faster onset of action in concordance with earlier studies. Peak analgesic effect was observed at 120 min post-treatment, which correlated with the pharmacokinetic profile of the drug in gel formulation. In this study, diclofenac was found to be superior to piroxicam though both drugs exhibited peak analgesic effect at 60 min post-treatment. In the modified Hollander method, a good correlation was found between the ten point category scale and the VAS, indicating that it may serve as a sensitive and reliable method for the screening of analgesic drugs. Conclusion: The superior analgesic activity of nimesulide (as gel formulation), correlating with its pharmacokinetic profile, indicates that the topical route of administration may be a safe and effective alternative to the presently used oral and rectal routes.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemical Engineering & Technology - CET 19 (1996), S. 443-447 
    ISSN: 0930-7516
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A novel expert-system-based method for selection of sensors for process variables is presented. EXSENSEL (expert system based sensor selection) deals with 12 process variables and currently has 94 rules in its knowledge base. Despite its large knowledge base, users have to answer a set of only a few questions regarding a particular process variable, which is selected from a menu of 12 variables. A general description of the chosen process variable can be viewed before invoking the rules. Once a sensor has been selected, a brief write up on that particular sensor is also available on user's request. EXSENSEL is the successor to TRANSELEX, which is a single expert system for selection of transducers in the area of temperature, pressure, and flow measurement.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 69 (1998), S. 279-291 
    ISSN: 0020-7608
    Keywords: quantum fluid density functional theory ; quantum theory of motion ; time-dependent processes ; electronegativity ; hardness ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A quantum fluid density functional theory has been developed through an amalgamation of the quantum fluid dynamics and the time-dependent density functional theory. It is used in studying typical time-dependent processes like ion-atom collisions and atom-field interaction. Temporal evolution of chemical reactivity parameters as electronegativity, hardness, entropy, and polarizability is monitored for a He atom in its ground and excited states interacting with an external electric field and an incoming proton. It is observed that these reactivity parameters either remain static or oscillate with the external field in the atom-field interaction case, whereas during the collision process, hardness and entropy maximize and polarizability minimizes for both the electronic states of the atom. The possibility of a quantum theory of motion within the purview of this quantum fluid density functional framework is also explored.   © 1998 John Wiley & Sons, Inc. Int J Quant Chem 69: 279-291, 1998
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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