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  • Enhanced hypercube  (1)
  • enzymic degradation  (1)
  • 1995-1999  (2)
  • 1930-1934
  • 1925-1929
  • 1915-1919
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  • 1995-1999  (2)
  • 1930-1934
  • 1925-1929
  • 1915-1919
Year
  • 1
    ISSN: 1432-1769
    Keywords: Proteus ; INSIGHT ; Reconfigurable computational network ; MIMD ; Enhanced hypercube ; Parallel computing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract The Proteus architecture is a highly parallel, multiple instruction, multiple data machine (MIMD) optimized for large granularity tasks such as machine vision and image processing. The system can achieve 20 gigaflops (80 gigaflops peak). It accepts data via multiple serial links at a rate of up to 640 MB/S. The system employs a hierarchical reconfigurable interconnection network with the highest level being a circuit-switchedenhanced hypercube, serial interconnection network for internal data transfers. The system is designed to use 256 to 1024 RISC processors. The processors use 1-MB externalread/write allocating caches for reduced multiprocessor contention. The system detects, locates, and replaces faulty subsystems using redundant hardware to facilitatefault tolerance. The parallelism is directly controllable through an advanced software system for partitioning, scheduling, and development. System software includes a translator for the INSIGHT language, a parallel debugger, lowand high-level simulators, and a message-passing system for all control needs. Image-processing application software includes a variety of point operators, neighborhood operators, convolution, and the mathematical morphology operations of binary and gray-scale dilation, erosion, opening, and closing.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pharmaceutical research 13 (1996), S. 1210-1212 
    ISSN: 1573-904X
    Keywords: colonic delivery ; pectin ; ethylcellulose ; film coating ; enzymic degradation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. The purpose of the study was to investigate the potential of pectin, ethylcellulose combinations as a practical film coating for colonic delivery. Methods. Combinations of pectin and ethylcellulose, in the form of an aqueous dispersion, were used as coating formulations. Paracetamol cores were used as the substrate. The coatings were assessed by a flow through dissolution system simulating in vivo conditions by changes in pH and residence time. Pectinolytic enzymes were used to simulate the bacterial flora of the colon. Results. Drug release was controlled by the ratio of ethylcellulose to pectin in the film coat. Increasing the proportion of ethylcellulose and increasing the coat weight reduced drug release in pHl and pH7.4 media. The addition of pectinolytic enzymes to pH6 media increased the release of drug. Conclusions. Combinations of ethylcellulose and pectin can provide protection to a drug in the upper g.i. tract while allowing enzymatic breakdown and drug release in the colon.
    Type of Medium: Electronic Resource
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