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  • 1
    Electronic Resource
    Electronic Resource
    tBHP induced in vitro swelling of rat liver mitochondria (1996)
    Springer
    Molecular and cellular biochemistry 154 (1996), S. 39-45 
    Details
    ISSN: 1573-4919
    Keywords: free radicals ; oxidative stress ; mitochondrial swelling ; tert-butyl hydroperoxide ; calcium deregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Tert-butyl hydroperoxide induced swelling of freshly isolated rat liver mitochondria was inhibited by butylated hydroxytoluene, butylated hydroxyanisole and α-tocopherol by acting at the initial phase. EDTA was more effective than EGTA in reducing the initial swelling and so were desferal and bipyrridyl. Spermine, an allosteric activator of calcium uptake, enhanced swelling whereas lanthanum and ruthenium red, the Ca2+ uniport blockers, reduced it. Inhibition of phospholipase A2 by dibucaine and Ca2+ activated proteases by antipain and leupeptin also reduced t-BHP induced swelling. The data indicate that peroxidative mitochondrial swelling involves an iron mediated initial rapid phase and a subsequent calcium dependent propagation phase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00248459
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of Antioxidants on the Peroxidative Swelling of Mitochondria in vitro (1998)
    Springer
    Cell biology and toxicology 14 (1998), S. 313-321 
    Details
    ISSN: 1573-6822
    Keywords: antioxidants ; free radicals ; oxidative swelling ; peroxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract To clarify the role of prooxidative processes during in vitro swelling of freshly isolated rat liver mitochondria, the influence of different antioxidants and free-radical scavengers was tested. Ascorbate below 10 mmol/L without externally added Fe2+ acted as a prooxidant and enhanced swelling. Higher concentrations in the presence of Fe2+ showed antioxidant properties and a decrease in swelling and lipid peroxidation. Swelling was abolished by α-tocopherol and reduced to 50% by butylated hydroxytoluene. Glutathione supplementation decreased both swelling and lipid peroxidation. Oxidized glutathione caused swelling without any effect on peroxidation. Hydrogen peroxide, cumene hydroperoxide and t-butyl hydroperoxide caused progressive decreases in glutathione and reduced niacinamide coenzyme levels, suggesting prooxidative changes. Dithiothreitol was found to abolish this effect. Thus, antioxidants reverse superoxide-induced mito chondrial swelling and lipid peroxidation in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007529622874
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    Paper (German National Licenses)
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