ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

Unknown

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor (1995)

W. J. Koch ; H. A. Rockman ; P. Samama ; [et al.]

American Association for the Advancement of Science (AAAS)

In: Science. 268(5215): 1350-3.

add to mindlist on the mindlist

Details

Publication Date: 1995-06-02

Description: Transgenic mice were created with cardiac-specific overexpression of the beta-adrenergic receptor kinase-1 (beta ARK1) or a beta ARK inhibitor. Animals overexpressing beta ARK1 demonstrated attenuation of isoproterenol-stimulated left ventricular contractility in vivo, dampening of myocardial adenylyl cyclase activity, and reduced functional coupling of beta-adrenergic receptors. Conversely, mice expressing the beta ARK inhibitor displayed enhanced cardiac contractility in vivo with or without isoproterenol. These animals demonstrate the important role of beta ARK in modulating in vivo myocardial function. Because increased amounts of beta ARK1 and diminished cardiac beta-adrenergic responsiveness characterize heart failure, these animals may provide experimental models to study the role of beta ARK in heart disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koch, W J -- Rockman, H A -- Samama, P -- Hamilton, R A -- Bond, R A -- Milano, C A -- Lefkowitz, R J -- 5F32-CA09350/CA/NCI NIH HHS/ -- HL-16037/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1995 Jun 2;268(5215):1350-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7761854" target="_blank"〉PubMed〈/a〉

Keywords: Adenylyl Cyclases/metabolism ; Animals ; Blood Pressure ; Cyclic AMP-Dependent Protein Kinases/antagonists & ; inhibitors/genetics/*metabolism ; GTP-Binding Proteins/metabolism ; Heart/*physiology ; Isoproterenol/pharmacology ; Mice ; Mice, Transgenic ; *Myocardial Contraction/drug effects ; Myocardium/*enzymology ; Phenotype ; Receptors, Adrenergic, beta/*metabolism ; Sarcolemma/enzymology ; Ventricular Pressure ; beta-Adrenergic Receptor Kinases

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

PAPER CURRENT

S·F·X

Fulltext

2

Electronic Resource

Plans for conversion of SURF II to SURF III : The 9th National conference on synchrotron radiation instrumentation (1996)

Hamilton, A. D. ; Furst, M. L. ; Hughey, L. R. ; [et al.]

[S.l.] : American Institute of Physics (AIP)

Review of Scientific Instruments 67 (1996), S. 3345-3346

add to mindlist on the mindlist

Details

ISSN: 1089-7623

Source: AIP Digital Archive

Topics: Physics , Electrical Engineering, Measurement and Control Technology

Notes: The Synchrotron Ultraviolet Radiation Facility (SURF II) at the National Institute of Standards and Technology, Gaithersburg, MD, USA, has served as a primary radiometric standard in the vacuum ultraviolet region since its conversion from a synchrotron to an electron storage ring in 1974. The magnet iron, however, dates back to an original betatron design of the late 1940s. The advent of both modern materials and methods of finite element analysis have made possible the design of magnets offering far greater dc performance than the existing SURF system. In this paper we discuss the general design and plans to convert SURF II to SURF III, which will offer reduced radiometric uncertainty, an increase in energy from 300 MeV to 385 MeV, a modernized control system, and two new beamlines, which are not presently possible. Anticipated new beamline activities include a substantial new effort devoted to radiometric improvements from IR to far UV and development of stations for microspectoscopy and electroreflectance. © 1996 American Institute of Physics.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1063/1.1147454

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

3

Electronic Resource

Fabrication of high mobility in situ back-gated (311)A hole gas heterojunctions (1997)

Simmons, M. Y. ; Hamilton, A. R. ; Stevens, S. J. ; [et al.]

Woodbury, NY : American Institute of Physics (AIP)

Applied Physics Letters 70 (1997), S. 2750-2752

add to mindlist on the mindlist

Details

ISSN: 1077-3118

Source: AIP Digital Archive

Topics: Physics

Notes: Using an n-type (311)A GaAs substrate we have fabricated in situ back-gated GaAs/(Al,Ga)As hole gases with mobilities of μ=1.1×106 cm2 V−1 s−1 at 30 mK. We have investigated both experimentally and theoretically the scattering mechanisms that limit the mobility in both the [2¯33] and [011¯] directions. Using a combination of front and back gates to keep the carrier density constant, we can distinguish between scattering mechanisms which are primarily dependent on the carrier density and those that are sensitive to the shape of the hole wave function. This approach also eliminates complications arising from the variations of the Fermi surface anisotropy with carrier density. Our data confirms that anisotropic interface roughness scattering, arising from the nature of the (311)A GaAs surface, is the dominant scattering mechanism at carrier densities down to ps=5.0×1010 cm−2. © 1997 American Institute of Physics.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1063/1.119012

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

4

Electronic Resource

Use of transgenic plants to study the role of ethylene and polygalacturonase during infection of tomato fruit by Colletotrichum gloeosporioides (1998)

Cooper, W. ; Bouzayen, M. ; Hamilton, A. ; [et al.]

Oxford, U.K. and Cambridge, USA : Blackwell Publishers

Plant pathology 47 (1998), S. 0

add to mindlist on the mindlist

Details

ISSN: 1365-3059

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Notes: The infection of tomato fruit by the postharvest pathogen Colletotrichum gloeosporioides did not proceed until the onset of ripening in response to ethylene. Compared with fruit from wild-type plants, infection progressed more slowly in transgenic fruit in which ethylene biosynthesis and ripening had been inhibited by an ACC oxidase (ACO) antisense transgene. In contrast, transgenic fruit deficient in polygalacturonase developed lesions at the same rate as the wild-type fruit. Ethylene biosynthesis increased rapidly in response to infection of ripe wild-type and ACO antisense fruit but was 25 times greater in the former. Fruit from the ripening mutant ripening inhibitor (rin), which are normally very resistant to infection, became infected quickly when incubated in the presence of ethylene, whereas fruit incubated in the absence of ethylene remained healthy. The ACO 1 mRNA accumulated to detectable levels within 24 h of inoculation of unripe wild-type fruit, prior to the development of visible symptoms, whereas there was no detectable expression in the inoculated ACO antisense fruit. ACO transcripts accumulated to maximum levels during the early stages of infection of ripe fruit, correlating with maximum ethylene biosynthesis. Northern analysis using gene-specific probes for each of the three ACO genes indicated that ACO 1 was the main gene expressed in response to infection and that there was no detectable expression of ACO 2 and 3.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1365-3059.1998.00228.x

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

5

Electronic Resource

Thelytokous Parthenogenesis for Four Generations in the Desert Locust ( Schistocerca gregaria Forsk) (Acrididæ) (1953)

HAMILTON, A. G.

[s.l.] : Nature Publishing Group

Nature 172 (1953), S. 1153-1154

add to mindlist on the mindlist

Details

ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] It is the second type which I believe occurs exclusively in the desert locust. Parthenogenesis of the thelytokous type has been recorded for many Acrididse ; for example, Plotnikov1 for the migratory locust (Locusta migratoria), Slifer and King2'3 for many species of grasshoppers. Nabours4 with a ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/1721153a0

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

6

Electronic Resource

Polymely in a Frog (1950)

HAMILTON, A. G.

[s.l.] : Nature Publishing Group

Nature 166 (1950), S. 611-612

add to mindlist on the mindlist

Details

ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Fig. 1. X-ray showing articulation of supernumerary left fore limb with pectoral girdle The supernumerary limb on this specimen was about four-fifths of the size of a normal limb, and complete as far as the wrist joint; but the meta-carpals and phalanges were missing, perhaps as the result of ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/166611a0

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

7

Electronic Resource

Identification of transposon-like elements in non-coding regions of tomato ACC oxidase genes (1997)

Blume, B. ; Barry, C. S. ; Hamilton, A. J. ; [et al.]

Springer

Molecular genetics and genomics 254 (1997), S. 297-303

add to mindlist on the mindlist

Details

ISSN: 1617-4623

Keywords: Key words ACC oxidase ; Promoters ; Tomato ; Transposable elements

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract 1-aminocyclopropane-1-carboxylate (ACC) oxidase, which catalyses the terminal step in ethylene biosynthesis, is encoded by a small multigene family in tomato that is differentially expressed in response to developmental and environmental cues. In this study we report the isolation and sequencing of approximately 2 kb of 5′-flanking sequence of three tomato ACC oxidase genes (LEACO1, LEACO2, LEACO3) and the occurrence of class I and class II mobile element-like insertions in promoter and intron regions of two of them. The LEACO1 upstream region contains a 420-bp direct repeat which is present in multiple copies in the tomato genome and is very similar to sequences in the promoters of the tomato E4 and 2A11 genes. The region covering the repeats resembles the remnant of a retrotransposon. Two copies of a small transposable element, belonging to the Stowaway inverted repeat element family, have been found in the 5′-flanking sequence and the third intron of LEACO3.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004380050419

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

8

Electronic Resource

Nucleotide sequence of a gene encoding an organophosphorus nerve agent degrading enzyme from Alteromonas haloplanktis (1997)

Cheng, T-c ; Liu, L ; Wang, B ; [et al.]

Springer

Journal of industrial microbiology and biotechnology 18 (1997), S. 49-55

add to mindlist on the mindlist

Details

ISSN: 1476-5535

Keywords: Keywords: Alteromonas organophosphorus acid anhydrolase gene; X-Pro dipeptidase; sequencing and functional homology to prolidase

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: Organophosphorus acid anhydrolases (OPAA) catalyzing the hydrolysis of a variety of toxic organophosphorus cholinesterase inhibitors offer potential for decontamination of G-type nerve agents and pesticides. The gene (opa) encoding an OPAA was cloned from the chromosomal DNA of Alteromonas haloplanktis ATCC 23821. The nucleotide sequence of the 1.7-kb DNA fragment contained the opa gene (1.3 kb) and its flanking region. We report structural and functional similarity of OPAAs from A. haloplanktis and Alteromonas sp JD6.5 with the enzyme prolidase that hydrolyzes dipeptides with a prolyl residue in the carboxyl-terminal position. These results corroborate the earlier conclusion that the OPAA is a type of X-Pro dipeptidase, and that X-Pro could be the native substrate for such an enzyme in Alteromonas cells.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/sj.jim.2900358

Permalink