Publication Date:
1997-10-24
Description:
Animals vary in their sensitivity to ethanol, a trait at least partly determined by genetic factors. In order to identify possible responsible genes, mice lacking Fyn, a non-receptor type tyrosine kinase, were investigated. These mice were hypersensitive to the hypnotic effect of ethanol. The administration of ethanol enhanced tyrosine phosphorylation of the N-methyl-D-aspartate receptor (NMDAR) in the hippocampus of control mice but not in Fyn-deficient mice. An acute tolerance to ethanol inhibition of NMDAR-mediated excitatory postsynaptic potentials in hippocampal slices developed in control mice but not in Fyn-deficient mice. These results indicate that Fyn affects behavioral, biochemical, and physiological responses to ethanol.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miyakawa, T -- Yagi, T -- Kitazawa, H -- Yasuda, M -- Kawai, N -- Tsuboi, K -- Niki, H -- New York, N.Y. -- Science. 1997 Oct 24;278(5338):698-701.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Neurobiology of Emotion, Brain Science Institute, RIKEN, Hirosawa, Wako-shi, Saitama-ken 351-01, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9381182" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Central Nervous System Depressants/*pharmacology
;
Ethanol/*pharmacology
;
Excitatory Postsynaptic Potentials/drug effects
;
Flurazepam/pharmacology
;
Hippocampus/metabolism
;
Hypnotics and Sedatives/pharmacology
;
In Vitro Techniques
;
Male
;
Mice
;
Mice, Knockout
;
Motor Activity/*drug effects
;
N-Methylaspartate/pharmacology
;
Phosphorylation
;
Phosphotyrosine/metabolism
;
Protein-Tyrosine Kinases/deficiency/genetics/*metabolism
;
Proto-Oncogene Proteins/deficiency/genetics/*metabolism
;
Proto-Oncogene Proteins c-fyn
;
Receptors, N-Methyl-D-Aspartate/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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