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  • KNI compound  (2)
  • OTA  (2)
  • Springer  (4)
  • 1995-1999  (4)
  • 1960-1964
  • 1935-1939
  • 1920-1924
Collection
Keywords
Publisher
  • Springer  (4)
Years
  • 1995-1999  (4)
  • 1960-1964
  • 1935-1939
  • 1920-1924
Year
  • 1
    Electronic Resource
    Electronic Resource
    The super-multi-tanh technique for bipolar linear transconductance amplifiers (1996)
    Springer
    Analog integrated circuits and signal processing 11 (1996), S. 137-147 
    Details
    ISSN: 1573-1979
    Keywords: the multi-tanh technique ; the emitter area ratio unbalance technique ; the super-multi-tanh technique, linear transconductance element ; OTA ; bipolar
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract A novel circuit design technique for bipolar linear transconductance amplifiers is presented. A triple-tail cell, which consists of three emitter-common transistors biased by a single tail current, is exchangeable with an emitter-coupled pair in the multi-tanh cell, such as a multi-tanh doublet, a multi-tanh triplet or a multi-tanh quad. Therefore, the multi-tanh technique is further theoretically expanded to the super-multi-tanh technique. In this paper, the super-multi-tanh technique is proposed and discussed, and furthermore, a super-multi-tanh doublet is verified with bipolar transistor-arrays and discrete resistors on a breadboard.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174248
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  • 2
    Electronic Resource
    Electronic Resource
    A linear CMOS transconductance element of an adaptively biased source-coupled differential pair using a quadritail cell (1996)
    Springer
    Analog integrated circuits and signal processing 11 (1996), S. 129-135 
    Details
    ISSN: 1573-1979
    Keywords: adaptive-biasing ; quadritail cell ; OTA ; CMOS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract A novel circuit design technique for realizing a linear CMOS transconductance element, consisting of an adaptively biased source-coupled differential pair using a quadritail cell, is proposed. In the circuitry, the quadritail cell, which provides an output current proportional to the square of a differential input voltage, cancels a nonlinear term of the source-coupled differential pair. The circuit have a superior linearity and a wide linear input voltage range compared with the conventional linear CMOS transconductance elements because the transconductance characteristic is theoretically linear over wide input voltage range when all the MOS field-effect transistors (MOSFETs) are operating in the saturation region and the MOSFETs' behaviors are according to the relation based on the square-law characteristic. The proposed adaptively biased source-coupled differential pair was verified by using transistor-arrays and discrete components on a breadboard.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174247
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Design of small peptidomimetic HIV-1 protease inhibitors and prodrug forms (1999)
    Springer
    International journal of peptide research and therapeutics 6 (1999), S. 275-281 
    Details
    ISSN: 1573-3904
    Keywords: acyl migration-type prodrug ; anti-HIV drug ; conjugate of HIV protease inhibitor with RT inhibitor ; HIV protease inhibitor ; KNI compound ; substrate transition state analog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The human immunodeficiency virus (HIV) contains an aspartic protease known to be essential for retroviral maturation and replication. Based on the transition state for substrate processing, we designed and synthesized a novel class of HIV-1 protease inhibitors containing an unnatural amino acid, allophenylnorstatine (i.e. (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid), with a hydroxymethylcarbonyl (HMC) isostere. The stereochemistry of the hydroxyl group was important for enzyme inhibition and the HMC group interacted efficiently with the aspartic acid carboxyl groups of the HIV-1 protease active site in essentially the same hydrogen bonding mode as the transition state. Small dipeptide-based HIV-1 protease inhibitors containing the HMC isostere were studied. Since some of these inhibitors showed low solubility in water, we designed a novel class of 'O→N intramolecular acyl migration'-type prodrugs of HIV-1 protease inhibitors for solubilization. Furthermore, we designed and synthesized a novel prodrug-type anti-HIV agent – the conjugate of a peptidomimetic HIV-1 protease inhibitor containing a free carboxylic acid with a nucleoside reverse transcriptase inhibitor. These studies may be useful in anti-HIV drug development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008944023236
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  • 4
    Electronic Resource
    Electronic Resource
    Design of small peptidomimetic HIV-1 protease inhibitors and prodrug forms (1999)
    Springer
    International journal of peptide research and therapeutics 6 (1999), S. 275-281 
    Details
    ISSN: 1573-3904
    Keywords: acyl migration-type prodrug ; anti-HIV drug ; conjugate of HIV protease inhibitor with RT inhibitor ; HIV protease inhibitor ; KNI compound ; substrate transition state analog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The human immunodeficiency virus (HIV) contains an aspartic protease known to be essential for retroviral maturation and replication. Based on the transition state for substrate processing, we designed and synthesized a novel class of HIV-1 protease inhibitors containing an unnatural amino acid, allophenylnorstatine (i.e. (2S, 3S)-3-amino-2-hydroxy-4-phenylbutyric acid), with a hydroxymethylcarbonyl (HMC) isostere. The stereochemistry of the hydroxyl group was important for enzyme inhibition and the HMC group interacted efficiently with the aspartic acid carboxyl groups of the HIV-1 protease active site in essentially the same hydrogen bonding mode as the transition state. Small dipeptide-based HIV-1 protease inhibitors containing the HMC isostere were studied. Since some of these inhibitors showed low solubility in water, we designed a novel class of ‘O→N intramolecular acyl migration’-type prodrugs of HIV-1 protease inhibitors for solubilization. Furthermore, we designed and synthesized a novel prodrug-type anti-HIV agent — the conjugate of a peptidomimetic HIV-1 protease inhibitor containing a free carboxylic acid with a nucleoside reverse transcriptase inhibitor. These studies may be useful in anti-HIV drug development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02443422
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    Paper (German National Licenses)
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