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  • American Geophysical Union  (129)
  • Cambridge University Press  (32)
  • International Union of Crystallography (IUCr)  (28)
  • Annual Reviews
  • 1995-1999  (174)
  • 1965-1969  (33)
  • 1945-1949
Collection
Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Crystallization and preliminary X-ray diffraction studies of a cobalt-substituted derivative of the iron-dependent alcohol dehydrogenase from Zymomonas mobilis (1996)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 218-220 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The iron-dependent alcohol dehydrogenase from Zymomonas mobilis has been crystallized in a form suitable for X-ray diffraction studies. The crystals grew in hanging drops by vapor diffusion, equilibrating with a solution comprising 25–27% methoxypolyethylene glycol 5000 and 1 mM Co2+ in a 0.2 M succinic acid/potassium hydroxide buffer at pH 5.5–5.7 at 281 K. Crystals are tetragonal, P4122 (or P4322), with unit-cell dimensions a = b = 125.7, c = 248.1 Å. Four molecules comprise the asymmetric unit, and a self-rotation function indicates twofold local symmetry perpendicular to the unique axis and 15° from a crystallographic twofold axis. Diffraction data to 3.0 Å have been collected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444995009103
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  • 2
    Electronic Resource
    Electronic Resource
    Structure of recombinant human lactoferrin expressed in Aspergillus awamori (1999)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 55 (1999), S. 403-407 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Human lactoferrin (hLf) has considerable potential as a therapeutic agent. Overexpression of hLf in the fungus Aspergillus awamori has resulted in the availability of very large quantities of this protein. Here, the three-dimensional structure of the recombinant hLf has been determined by X-ray crystallography at a resolution of 2.2 Å. The final model, comprising 5339 protein atoms (residues 1–691, 294 solvent molecules, two Fe3+and two CO_3^{2-} ions), gives an R factor of 0.181 (free R = 0.274) after refinement against 32231 reflections in the resolution range 10–2.2 Å. Superposition of the recombinant hLf structure onto the native milk hLf structure shows a very high level of correspondence; the main-chain atoms for the entire polypeptide can be superimposed with an r.m.s. deviation of only 0.3 Å and there are no significant differences in side-chain conformations or in the iron-binding sites. Dynamic properties, as measured by B-value distributions or iron-release kinetics, also agree closely. This shows that the structure of the protein is not affected by the mode of expression, the use of strain-improvement procedures or the changes in glycosylation due to the fungal system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444998011226
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  • 3
    Electronic Resource
    Electronic Resource
    MAMMALIAN DNA MISMATCH REPAIR (1999)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genetics 33 (1999), S. 533-564 
    Details
    ISSN: 0066-4197
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract DNA mismatch repair (MMR) is one of multiple replication, repair, and recombination processes that are required to maintain genomic stability in prokaryotes and eukaryotes. In the wake of the discoveries that hereditary nonpolyposis colorectal cancer (HNPCC) and other human cancers are associated with mutations in MMR genes, intensive efforts are under way to elucidate the biochemical functions of mammalian MutS and MutL homologs, and the consequences of defects in these genes. Genetic studies in cultured mammalian cells and mice are proving to be instrumental in defining the relationship between the functions of MMR in mutation and tumor avoidance. Furthermore, these approaches have raised awareness that MMR homologs contribute to DNA damage surveillance, transcription-coupled repair, and recombinogenic and meiotic processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.genet.33.1.533
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  • 4
    Electronic Resource
    Electronic Resource
    ADVENTURES IN HUMAN POPULATION BIOLOGY (1996)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Anthropology 25 (1996), S. 1-18 
    Details
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Notes: In this professional memoir I trace my career and the changes that occurred after World War II in the biological anthropology studies of human populations. I describe my academic training at the University of New Mexico and Harvard University and my research training at the US Climatic Research Laboratory. During my academic career at The Pennsylvania State University, I directed two multidisciplinary research efforts as part of the International Biological Programme and Man in the Biosphere Program. These were the high-altitude studies in Nunoa, Peru, and the migration and modernization studies of Samoan communities. I describe my participation in the development of these international science programs as well as the effects on the discipline of biological anthropology. In conclusion, I reflect on the growth and development of biological anthropology, particularly in human population biology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.anthro.25.1.1
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  • 5
    Electronic Resource
    Electronic Resource
    Chemotherapy of Animal Parasites (1968)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 8 (1968), S. 213-228 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.08.040168.001241
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  • 6
    Electronic Resource
    Electronic Resource
    CYTOTOXICITY OF SHORT-CHAIN ALCOHOLS (1999)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 39 (1999), S. 127-150 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Notes: Abstract Ethanol and other short-chain alcohols elicit a number of cellular responses that are potentially cytotoxic and, to some extent, independent of cell type. Aberrations in phospholipid and fatty acid metabolism, changes in the cellular redox state, disruptions of the energy state, and increased production of reactive oxygen metabolites have been implicated in cellular damage resulting from acute or chronic exposure to short-chain alcohols. Resulting disruptions of intracellular signaling cascades through interference with the synthesis of phosphatidic acid, decreases in phosphorylation potential and lipid peroxidation are mechanisms by which solvent alcohols can affect the rate of cell proliferation and, consequently, cell number. Nonoxidative metabolism of short-chain alcohols, including phospholipase D-mediated synthesis of alcohol phospholipids, and the synthesis of fatty acid alcohol esters are additional mechanisms by which alcohols can affect membrane structure and compromise cell function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pharmtox.39.1.127
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  • 7
    Electronic Resource
    Electronic Resource
    Intrafloral Ecology (1968)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 13 (1968), S. 385-414 
    Details
    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.en.13.010168.002125
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  • 8
    Electronic Resource
    Electronic Resource
    Mechanisms of Biological Control of Soil-Borne Pathogens (1968)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Phytopathology 6 (1968), S. 263-294 
    Details
    ISSN: 0066-4286
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.py.06.090168.001403
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  • 9
    Electronic Resource
    Electronic Resource
    Active Oxygen in Plant Pathogenesis (1995)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Phytopathology 33 (1995), S. 299-321 
    Details
    ISSN: 0066-4286
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.py.33.090195.001503
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  • 10
    Electronic Resource
    Electronic Resource
    Respiratory Electron Transport (1965)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Plant Physiology 16 (1965), S. 343-382 
    Details
    ISSN: 0066-4294
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pp.16.060165.002015
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