Publication Date:
1997-08-08
Description:
TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sheridan, J P -- Marsters, S A -- Pitti, R M -- Gurney, A -- Skubatch, M -- Baldwin, D -- Ramakrishnan, L -- Gray, C L -- Baker, K -- Wood, W I -- Goddard, A D -- Godowski, P -- Ashkenazi, A -- New York, N.Y. -- Science. 1997 Aug 8;277(5327):818-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Oncology, Genentech, South San Francisco, CA 94080-4918, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9242611" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
*Apoptosis
;
Apoptosis Regulatory Proteins
;
Cell Membrane/metabolism
;
Cells, Cultured
;
GPI-Linked Proteins
;
Glycosylphosphatidylinositols/metabolism
;
HeLa Cells
;
Humans
;
Ligands
;
Membrane Glycoproteins/*metabolism
;
Molecular Sequence Data
;
NF-kappa B/metabolism
;
Receptors, TNF-Related Apoptosis-Inducing Ligand
;
Receptors, Tumor Necrosis Factor/chemistry/genetics/*metabolism
;
Signal Transduction
;
TNF-Related Apoptosis-Inducing Ligand
;
Transfection
;
Tumor Cells, Cultured
;
Tumor Necrosis Factor Decoy Receptors
;
Tumor Necrosis Factor-alpha/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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