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  • Chemistry  (13)
  • BIOTECHNOLOGY  (2)
  • Mutation
  • 1995-1999  (9)
  • 1970-1974  (4)
  • 1925-1929  (3)
  • 1900-1904  (1)
  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1998-07-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Epstein, E -- New York, N.Y. -- Science. 1998 Jun 19;280(5371):1906-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Land, Air and Water Resources-Soils and Biogeochemistry, Universsity of California at Davis 95616-8627, USA. eqepstein@ucdavis.e eqepstein@ucdavis.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9669949" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/genetics/metabolism ; *Arabidopsis Proteins ; Calcium/*metabolism ; Genes, Plant ; Ion Transport ; Mutation ; Plant Proteins/chemistry/*genetics/*metabolism ; Plants/genetics/*metabolism ; Potassium/metabolism ; Second Messenger Systems ; Signal Transduction ; Sodium/metabolism/*pharmacology ; Water/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1997-05-02
    Description: Mutations in the tumor suppressor gene PATCHED (PTC) are found in human patients with the basal cell nevus syndrome, a disease causing developmental defects and tumors, including basal cell carcinomas. Gene regulatory relationships defined in the fruit fly Drosophila suggest that overproduction of Sonic hedgehog (SHH), the ligand for PTC, will mimic loss of ptc function. It is shown here that transgenic mice overexpressing SHH in the skin develop many features of basal cell nevus syndrome, demonstrating that SHH is sufficient to induce basal cell carcinomas in mice. These data suggest that SHH may have a role in human tumorigenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oro, A E -- Higgins, K M -- Hu, Z -- Bonifas, J M -- Epstein, E H Jr -- Scott, M P -- AR39959/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 1997 May 2;276(5313):817-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305-5427, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9115210" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basal Cell Nevus Syndrome/*genetics/metabolism/pathology ; Carcinoma, Basal Cell/*genetics/metabolism/pathology ; Embryo, Mammalian ; *Gene Expression Regulation, Neoplastic ; Hedgehog Proteins ; Humans ; Intracellular Signaling Peptides and Proteins ; Keratinocytes/metabolism ; Male ; Membrane Proteins/genetics/metabolism ; Mice ; Mice, SCID ; Mice, Transgenic ; Mutation ; Neoplasm Transplantation ; Protein Biosynthesis ; Proteins/*genetics/metabolism ; Receptors, Cell Surface ; Skin/pathology ; Skin Neoplasms/*genetics/metabolism/pathology ; Skin Transplantation ; *Trans-Activators
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2019-06-27
    Description: The effects of the currently used U.S. Air Force (CSU-12/P) anti-G suit on renal function during positive radial acceleration (+Gz) were assessed in seven normal male subjects in balance on a 200 meq sodium diet. Following suit inflation in the seated position, +2.0 Gz for 30 min resulted in a decrease in the rate of sodium excretion from 125 plus or minus 19 to 60 plus or minus 14 microeq/min, which persisted during a 25-min recovery period. Fractional excretion of sodium also decreased significantly during +Gz. The magnitude of the antinatriuresis was indistinguishable from that observed during +Gz without suit inflation. In contrast to the antinatriuresis observed during centrifugation without suit, however, the antinatriuresis with suit was mediated primarily by an enhanced tubular reabsorption of sodium.
    Keywords: BIOTECHNOLOGY
    Type: Journal of Applied Physiology; 36; Mar. 197
    Format: text
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  • 4
    Publication Date: 2019-06-27
    Description: The effects of positive radial centrifugation (+Gz) on plasma resin activity (PRA) and renal function were assessed in 15 normal male subjects under carefully controlled conditions of Na, K, and water intake. Twenty minutes of +2.0 Gz resulted in significant decreases in the mean rate of sodium excretion and creatine clearance and in a doubling of PRA in seven sodium-depleted subjects (10 meq Na intake). In eight sodium-replete subjects (200 mq Na intake), 30 min of +2.0 Gz was also associated with a decrease in the mean rate of sodium excretion. As a consequence of a concurrent decrease in creatine clearance, the fractional excretion of sodium during centrifugation did not differ from control, suggesting that the changes in Na excretion were mediated primarily by renal hemodynamic factors, although enhanced renal tubular sodium reabsorption may also have played a role.
    Keywords: BIOTECHNOLOGY
    Type: Journal of Applied Physiology; 36; Mar. 197
    Format: text
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 42 (1904), S. 341-352 
    ISSN: 0863-1778
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 33 (1995), S. 1227-1234 
    ISSN: 0887-624X
    Keywords: polyanilines ; derivatives ; chemical synthesis ; oxidation state ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Syntheses of parent polyaniline and methyl, methoxy, and ethoxy ortho-substituted polyanilines were performed using the conventional chemical methodology and monitored using the new open-circuit-potential (Voc) profile technique. The intermediate pernigraniline oxidation state was identified and isolated at the Voc maximum (A) during the conventional chemical synthesis of poly(o-methoxyaniline) in the emeraldine oxidation state. The introduction of the substituent on the aniline ring leads to longer polymerization times and lower Voc values. Syntheses in the presence of two different monomers in solution were also investigated and showed preferential polymerization of the monomer with the lowest Voc potential. All polymers produced were characterized by elemental analysis, gel permeation chromatography, UV-VIS spectroscopy, and cyclic voltammetry. The influence of the substituent on the Voc profile and on the polymer characteristics are rationalized in terms of steric and electronic effects. © 1995 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0935-9648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 20 (1974), S. 678-687 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Growth and dissolution rates of nickel sulfate α-hexahydrate were measured as functions of the concentration driving force in a laboratory-scale fluidized-bed crystallizer for the temperature range 35° to 50°C and the crystal size range 0.5 to 4.0 mm.Dissolution rates at a given temperature and crystal size were first order in the concentration driving force. Growth rates were about one-quarter of dissolution rates and depended on a higher exponent (around 1.3) of the concentration driving force. This exponent was not significantly affected by variations in crystal size, but decreased as temperature increased. The apparent variation of growth rate itself with crystal size at constant temperature was slight. Growth rates were found to be insensitive to solids concentration.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 34 (1996), S. 1005-1018 
    ISSN: 0887-6266
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The dilute solution properties of copolymers are briefly discussed in relation to those of the parent homopolymers. It is shown that copolymer molecules are usually more expanded in solution than would be expected from the averaged behavior of the pure polymers, because of repulsive interactions between the unlike monomer units. A thermodynamic parameter χAB characterizing these interactions can be derived from measurements of the dilute solution properties of copolymers. In favorable cases this parameter can be independently evaluated from studies of ternary systems composed of the two parent homopolymers and a solvent, thus allowing prediction of the behavior of the copolymer. Light scattering and viscosity measurements on fractions of approximately equimolal copolymers of styrene and methyl methacrylate are presented and analyzed. The values of χAB deduced from the results in two solvents agree satisfactorily with each other, but are somewhat larger than those earlier obtained from measurements on ternary systems.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 57 (1995), S. 751-765 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The influence of fiber type and fiber-surface properties on matrix flow behavior was investigated using structural reaction injection-molding (SRIM). The influence of fiber type, fiber-surface properties, and matrix type on strength properties in elastomeric composites reinforced with nonwoven fibrous structures was investigated using tensile tests on elastomer composite samples from SRIM and latex coagulation (LC) fabrication methods and the microbond strength method on individual fibers. The fibers used were PET, LLDPE, and p-aramid. Fibers were treated with epoxy, styrene, and isocyanate derivatives, which make the surface chemically reactive. Treatments were also made with NaOH and a copolymer of polyester and polyol ether, causing a change in the fiber surface energy. The matrix types were polyurethane elastomer and natural rubber. The results show that the surface treatments which produced a change in the surface energy influenced the flow rate of the matrix polymer during the composite fabrication process. The treatments resulted in chemically reactive fiber surfaces which improved the fiber-matrix bond strength without affecting the Young's modulus of the composite material. Good correlation was found between bond strength and surface energy including the dispersive component of surface energy in the case of polyurethane elastomer and surface-modified PET fibers. The age of the polyurethane matrix has a marked influence on the bond strength. The fiber volume fraction in composites has a strong influence on the Young's modulus of the elastomer composite. © 1995 John Wiley & Sons, Inc.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
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