Publication Date:
1997-05-02
Description:
Mutations in the tumor suppressor gene PATCHED (PTC) are found in human patients with the basal cell nevus syndrome, a disease causing developmental defects and tumors, including basal cell carcinomas. Gene regulatory relationships defined in the fruit fly Drosophila suggest that overproduction of Sonic hedgehog (SHH), the ligand for PTC, will mimic loss of ptc function. It is shown here that transgenic mice overexpressing SHH in the skin develop many features of basal cell nevus syndrome, demonstrating that SHH is sufficient to induce basal cell carcinomas in mice. These data suggest that SHH may have a role in human tumorigenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oro, A E -- Higgins, K M -- Hu, Z -- Bonifas, J M -- Epstein, E H Jr -- Scott, M P -- AR39959/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 1997 May 2;276(5313):817-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305-5427, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9115210" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Basal Cell Nevus Syndrome/*genetics/metabolism/pathology
;
Carcinoma, Basal Cell/*genetics/metabolism/pathology
;
Embryo, Mammalian
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*Gene Expression Regulation, Neoplastic
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Hedgehog Proteins
;
Humans
;
Intracellular Signaling Peptides and Proteins
;
Keratinocytes/metabolism
;
Male
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Membrane Proteins/genetics/metabolism
;
Mice
;
Mice, SCID
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Mice, Transgenic
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Mutation
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Neoplasm Transplantation
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Protein Biosynthesis
;
Proteins/*genetics/metabolism
;
Receptors, Cell Surface
;
Skin/pathology
;
Skin Neoplasms/*genetics/metabolism/pathology
;
Skin Transplantation
;
*Trans-Activators
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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