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  • Articles  (85)
  • 1995-1999  (24)
  • 1970-1974  (19)
  • 1965-1969  (14)
  • 1955-1959  (14)
  • 1940-1944  (14)
  • Medicine  (84)
  • Computer Science  (22)
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  • Articles  (85)
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  • 1
    Electronic Resource
    Electronic Resource
    MECHANISMS OF OLFACTORY DISCRIMINATION:Converging Evidence for Common Principles Across Phyla (1997)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 20 (1997), S. 595-631 
    Details
    ISSN: 0147-006X
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Olfaction begins with the transduction of the information carried by odor molecules into electrical signals in sensory neurons. The activation of different subsets of sensory neurons to different degrees is the basis for neural encoding and further processing of the odor information by higher centers in the olfactory pathway. Recent evidence has converged on a set of transduction mechanisms, involving G-protein-coupled second-messenger systems, and neural processing mechanisms, involving modules called glomeruli, that appear to be adapted for the requirements of different species. The evidence is highlighted in this review by focusing on studies in selected vertebrates and in insects and crustaceans among invertebrates. The findings support the hypothesis that olfactory transduction and neural processing in the peripheral olfactory pathway involve basic mechanisms that are universal across most species in most phyla.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.neuro.20.1.595
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  • 2
    Electronic Resource
    Electronic Resource
    Hormone Induced Modification of the Cell Surface (1969)
    [s.l.] : Nature Publishing Group
    Nature 224 (1969), S. 344-345 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Steroid hormones control synthesis of a specific cell surface factor as well as the enzyme tyrosine aminotransferase in mammalian ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/224344a0
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  • 3
    Electronic Resource
    Electronic Resource
    Rational Geometry for measuring Elastic and Viscoelastic Parameters (1968)
    [s.l.] : Nature Publishing Group
    Nature 217 (1968), S. 735-735 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Elasticity investigations depend on measuring deformation in response to an applied force. The geometry of the area over which the force is applied to the specimen is important, for it will enter the interpretation of experimental data through the boundary conditions for the differential equations ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/217735a0
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  • 4
    Electronic Resource
    Electronic Resource
    Bioprospecting for drugs (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 393 (1998), S. 301-301 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SirIn an article on bioprospecting, one of us (D. N.) was quoted to the effect that “only one sample in 250,000 will directly yield a commercial drug, although many more samples may serve as useful leads for modification through combinatorial chemistry”. It ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/30586
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  • 5
    Electronic Resource
    Electronic Resource
    Enzymatic Synthesis of N-Glucuronic Acid Conjugates (1957)
    [s.l.] : Nature Publishing Group
    Nature 179 (1957), S. 538-539 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Incubation of aniline with the microsomes of guinea pig liver and uridine diphosphate glucuronic acid resulted in the disappearance of the free amino -group of aniline (Table 1). Little or no disappearance of the amine was observed in the absence of uridine diphosphate glucuronic acid or when this ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/179538a0
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  • 6
    Electronic Resource
    Electronic Resource
    Prophylactic use of human endotoxin-core hyperimmune gammaglobulin to prevent endotoxaemia in colostrum-deprived, gnotobiotic lambs challenged orally with Escherichia coli (1995)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 11 (1995), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract The efficacy of human IgG polyclonal antibody to endotoxin-core in preventing endotoxaemia and subsequent disease was studied in colostrum-deprived gnotobiotic lambs challenged orally at about 5 h old with 109 cfu Escherichia coli. Human endotoxin-core hyperimmune gammaglobulin was given intravenously to 5 lambs at 1.9 g IgG/kg bodyweight prior to challenge. Human albumin was given intravenously to 3 control lambs. Bacteraemia was observed in all lambs, but the incidence was lower (P 〈 0.01) and the onset later (P 〈 0.05) in gammaglobulin pre-treated lambs. These lambs showed no signs of disease, whereas clinical endotoxaemia, manifesting as watery mouth disease, was diagnosed in 2 of the 3 control lambs which were killed between 18 and 22 h after challenge. Thus, prophylactic treatment of colostrum-deprived lambs with human IgG enriched in endotoxin-core antibodies was effective in reducing the degree of bacteraemia and preventing endotoxaemia, leukopenia and clinical disease following oral challenge with E. coli.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-695X.1995.tb00114.x
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  • 7
    Electronic Resource
    Electronic Resource
    Utilization of exogenous adenine by the rat (1955)
    Springer
    Cellular and molecular life sciences 11 (1955), S. 183-184 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Der Einbau von oral an Ratten verabreichtem Adenin-8-C13 in den Purinanteil der Nukleinsäuren wurde mit den in der Literatur für die Aufnahme von Adenin-1, 3-N15 beschriebenen Werten verglichen. Die wesentlich geringere Aufnahme von Adenin-8-C13 lässt darauf schliessen, dass der Einbau von exogenen Purinen unter Ringöffnung erfolgt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02161307
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  • 8
    Electronic Resource
    Electronic Resource
    Inhibition of Adrenal 11β-Hydroxylation by Ions (1957)
    [s.l.] : Nature Publishing Group
    Nature 180 (1957), S. 337-337 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the present study, the latter were extracted from acetone powders prepared from bovine or porcine adrenal mitochondria, and hydroxylating activity was assayed nuorimetrically, as described earlier3. During attempts to fractionate the adrenal extracts with ammonium sulphate and other salts, it ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/180337a0
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  • 9
    Electronic Resource
    Electronic Resource
    Statistical Mechanics and the Critically Branched State (1971)
    [s.l.] : Nature Publishing Group
    Nature 234 (1971), S. 96-97 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The distribution of Masson et al. has a mean (DPW) which does not diverge until a attains the value 2/f, where the DPn of both distributions diverges also. This point is the limiting conversion possible for a strictly tree-like gel (that is, one free from rings) and Bruneau8 has also sought to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/234096a0
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  • 10
    Electronic Resource
    Electronic Resource
    Olfactory receptors guide axons (1995)
    [s.l.] : Nature Publishing Group
    Nature 377 (1995), S. 19-20 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR-Subsets of olfactory receptor neu-rons (ORNs), each expressing a particular type of receptor protein1'2, are broadly dis-tributed in the sensory epithelium3'4; yet members of each subset send their axons to only one or a few of some 2,000 mod-ules, called glomeruli, in the olfactory bulb5'6. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/377019b0
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