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  • 1995-1999  (27)
  • 1975-1979  (25)
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  • 1
    Electronic Resource
    Electronic Resource
    Covalent structure of collagen: amino acid sequence of chick skin collagen α1(I)-CB6B (1978)
    s.l. : American Chemical Society
    Biochemistry 17 (1978), S. 5719-5722 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00619a018
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  • 2
    Electronic Resource
    Electronic Resource
    Covalent structure of collagen. Amino acid sequence of α1-CB3 of chick skin collagen (1975)
    s.l. : American Chemical Society
    Biochemistry 14 (1975), S. 1929-1933 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00680a019
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  • 3
    Electronic Resource
    Electronic Resource
    Covalent structure of collagen. Amino acid sequence of α1-CB6A of chick skin collagen (1975)
    s.l. : American Chemical Society
    Biochemistry 14 (1975), S. 1933-1938 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00680a020
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  • 4
    Electronic Resource
    Electronic Resource
    Tilted n-fold symmetric radio frequency pulse sequences: Applications to CSA and heteronuclear dipolar recoupling in homonuclear dipolar coupled spin networks (1998)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 108 (1998), S. 7286-7293 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We describe new solid-state NMR methods for measuring the magnitude of the chemical shift anisotropy (CSA) and/or the heteronuclear dipolar coupling in the presence of homonuclear dipolar coupled spin networks under magic-angle spinning (MAS). The techniques employ 2π/5 phase shifts of a frequency switched Lee–Goldburg irradiation scheme which recouples the CSA and/or the heteronuclear dipolar coupling while simultaneously decoupling the homonuclear dipolar interactions. The induced spin dynamics are sensitive to the magnitude of the CSA and its asymmetry and may be implemented under conditions where the MAS rate exceeds the size of the anisotropic interactions. These approaches could find use in measurements of the magnitudes and relative orientations of CSA and/or heteronuclear dipolar couplings to extract torsion angles in uniformly labeled systems. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.476146
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  • 5
    Electronic Resource
    Electronic Resource
    Two-dimensional simulation of bromide transport in a heterogeneous field soil with transient unsaturated flow (1999)
    Oxford, UK : Blackwell Science Ltd
    European journal of soil science 50 (1999), S. 0 
    Details
    ISSN: 1365-2389
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: As a consequence of spatial heterogeneity, solute transport and associated phenomena of soil in the field are typically complex and often poorly described by current one-dimensional models. Therefore, better descriptions should be obtained if the specific variation of the soil is explicitly accounted for. To test this hypothesis, we simulated the two-dimensional transport of a bromide trace in pore-water velocity fields which varied in both space and time. We used data obtained in a field experiment in which we studied bromide transport as input parameters and boundary conditions for the simulation. We conceptualized heterogeneity at two spatial scales. Large regions with constant spatial properties were defined by the measured geometry of the soil’s horizons. On these we superimposed small structures derived from a correlated random field of scaling factors and conditioned on measured hydraulic properties. Simulations with homogeneous and heterogeneous horizons show that both coarse and fine hydraulic variation contribute to characteristic experimental phenomena such as concentration ‘hot spots’, especially near irregularities of horizon boundaries, and early breakthrough of solute leading to large dispersion at the field scale. The comparison between simulation and experimental results demonstrates that these features are reproduced if local hydraulic variation is included in the description of the transport. As expected, the quantitative agreement is limited, since the concentration distribution is strongly sensitive to local hydraulic conditions which were only partly accounted for by the measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2389.1999.00273.x
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  • 6
    Electronic Resource
    Electronic Resource
    Vacuolar H+-ATPase and weak base action in Dictyostelium (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 22 (1996), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Amoebae of Dictyostelium discoideum release ammonia during development, and the accumulation of this weak base is believed to be responsible for inhibiting fruiting-body formation and switching aggregates into migrating slugs. Exposure to weak bases can also inhibit aggregation and cell-type specific gene expression. The pathway by which weak bases influence development is not understood. We show here that the development of a set of mutants defective in acidification of intracellular acidic compartments is abnormally sensitive to inhibition by weak bases. Moreover even in the absence of added weak bases these mutants are delayed in aggregation and have a protracted migratory phase. The same behaviour is observed in trans-formants harbouring an antisense construct for one of the vacuolar H+-ATPase subunits. These results support the idea that weak bases exert their effects by inhibiting acidification of an intracellular acidic compartment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1996.tb02661.x
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  • 7
    Electronic Resource
    Electronic Resource
    Cell differentiation without morphogenesis in Dictyostelium discoideum (1976)
    [s.l.] : Nature Publishing Group
    Nature 262 (1976), S. 717-719 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Bonner2 reported that a proportion of amoebae of strain NC4 developed into large vacuolated stalk-like cells when plated on agar containing 1 mM cyclic AMP at cell densities that were too low to allow aggregation in controls without cyclic AMP. This observation was extended by Chia3 who showed that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/262717a0
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  • 8
    Electronic Resource
    Electronic Resource
    Algebraic specification of interconnection network relationships by permutation voltage graph mappings (1996)
    Springer
    Theory of computing systems 29 (1996), S. 451-470 
    Details
    ISSN: 1433-0490
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Symmetries of large networks are used to simplify the specification of a guest-host network relationship. The relevant kinds of symmetries occur not only in Cayley graphs and in group-action graphs, but elsewhere as well. In brief, the critical topological symmetry property of a guest or host is that it is algebraically specifiable as a covering space of a smaller graph. A first objective is to understand the circumstances under which a mapping (a.k.a. “embedding”) between two base graphs can be lifted topologically to a mapping between their respective coverings. A suitable assignment of algebraic elements called “permutation voltages” to a base graph for the intended host network facilitates the construction not only of the intended host, but also of the intended guest and of the intended mapping of the guest into the host. Explicit formulas are derived for measurement of the load, of the congestion, and of the dilation of the lifted mapping. A concluding example suggests how these new formulas open the opportunity to develop optimization methods for algebraically specified guest-host mappings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01184810
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  • 9
    Electronic Resource
    Electronic Resource
    The role of calcium in aggregation and development ofDictyostelium (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 1155-1165 
    Details
    ISSN: 1420-9071
    Keywords: ATPase ; cAMP ; calcium pools ; cGMP ; oscillation ; signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Changes in cytosolic Ca2+ play an important role in a wide array of cell types and the control of its concentration depends upon the interplay of many cellular constituents. Resting cells maintain cytosolic calcium ([Ca2+]i) at a low level in the face of steep gradients of extracellular and sequestered Ca2+. Many different signals can provoke the opening of calcium channels in the plasma membrane or in intracellular compartments and cause rapid influx of Ca2+ into the cytosol and elevation of [Ca2+]i. After such stimulation Ca2+ ATPases located in the plasma membrane and in the membranes of intracellular stores rapidly return [Ca2+]i to its basal level. Such responses to elevation of [Ca2+]i are a part of an important signal transduction mechanism that uses calcium (often via the binding protein calmodulin) to mediate a variety of cellular actions responsive to outside influences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01944733
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  • 10
    Electronic Resource
    Electronic Resource
    Progress in the prostaglandin E1-therapy of the intermittent claudication by means of bolus injections of LIPO-prostaglandin E1 (LIPO-PGE1) (1996)
    Springer
    European journal of clinical pharmacology 51 (1996), S. 235-239 
    Details
    ISSN: 1432-1041
    Keywords: Key words LIPO-Prostaglandin E1; intermittent claudication ; haemodynamics ; quantitative blood flow measurement ; transcutaneous oxygen pressure ; walking distance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: We compared the efficacy of a bolus injection (5 min) of LIPO-PGE1 (Prostaglandin E1 in lipid emulsion) with conventional PGE1-cyclodextrin (PGE1-cyclodextrin) infusions (2 h) in patients with intermittent claudication. The quantitative blood-flow in the common femoral artery was measured using a computerized ultrasound Doppler system (MAVIS®). we also monitored the transcutaneous oxygen pressure, the skin temperature on the foot, and the reactive change in blood pressure and pulse as well as side effects. Results : Dose finding of LIPO-PGE1: After bolus injection of 30, 50, and 80 μg LIPO-PGE1 a significant dose-dependent increase of the blood flow in the leg (+ 96.9%, 80 μg) with a peak 3 h after injection was seen. After LIPO-PGE1 we observed an enhanced microcirculation (significant rise in the transcutaneous oxygen pressure and the skin temperature on the foot). We noted longer lasting pharmacodynamic properties with LIPO-PGE1 (50 μg) compared to PGE1-cyclodextrin (60 μg). Comparison to PGE1-cyclodextrin: In a cross-over, placebo-controlled study, 20 patients with intermittent claudication received 4 weeks therapy with a bolus of 50 μg LIPO-PGE1 or a 2 h infusion of 60 μg PGE1-cyclodextrin per day. A significant increase in the blood flow was measured at the end of 4 weeks therapy compared to the initial values before treatment. This rise correlates significantly with the increase in the patient’s maximal walking distance (+112%, LIPO-PGE1). Compared to conventional PGE1-cyclodextrin infusions given over 2 h, a clearly prolonged increase in perfusion of the affected limb after LIPO-PGE1 was demonstrated. No serious adverse effects were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050190
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