ISSN:
1573-9171
Keywords:
ethyl acetoacetate
;
trifluoroacetonitrile
;
Ni(acac)2
;
catalysis
;
ethyl 2-acetyl-3-amino-04,4,4-trifluoro-2-butenoate
;
boron chelates
;
dimethylformamide dimethylacetal
;
3-ethoxycarbonyl-4-hydroxy-2-trifluoromethylpyridine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Ethyl 2-acetyl-3-amino-4,4,4-trifluoro-2-butenoate was synthesized by treatment of ethyl acetoacetate with CF3CN in the presence of Ni(acac)2. Condensation of the diphenylboron chelate of the former with dimethylformamide dimethylacetal followed by refluxing in ethanol yielded 3-ethoxycarbonyl-4-hydroxy-2-trifluoromethylpyridine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00700905
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