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  • Analytical Chemistry and Spectroscopy  (3)
  • 1995-1999  (1)
  • 1975-1979  (2)
  • 1960-1964
  • 1
    Electronic Resource
    Electronic Resource
    Characterization of endogenous DNA adducts by liquid chromatography/electrospray ionization tandem mass spectrometry (1995)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 30 (1995), S. 1157-1166 
    Details
    ISSN: 1076-5174
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Endogenous carcinogens arising from normal metabolism are known to cause modifications to DNA by reacting with bases to form adducts. Malondialdehyde is a well characterized endogenous carcinogen that forms an adduct with 2′-deoxyguanosine. This adduct has been detected in rat and human liver DNA by gas chromatography/electron capture negative-ion chemical ionization mass spectrometry. A method has been developed based on liquid chromatography/electrospray ionization tandem mass spectrometry for the characterization of endogenous DNA adducts. Using this method, it was unequivocally established that the malondialdehyde adduct of 2′-deoxyguanosine was a constituent of human liver DNA. The methodology that has been developed should be applicable to the characterization of other endogenous DNA adducts. There are few structural or biological data available to assess the importance of endogenous DNA adducts as premutagenic lesions responsible for the development of cancer. The availability of methodology based on liquid chromatography/electrospray ionization tandem mass spectrometry for the characterization of DNA adducts should greatly facilitate future studies in this area.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jms.1190300813
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  • 2
    Electronic Resource
    Electronic Resource
    Metastable ion studies. IX - Thermochemistry and ion structures among fragmentating ions, an electron impact and field ionization investigation (1977)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 12 (1977), S. 424-431 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Metastable peak shapes, dimensions and relative abundances have been measured for the fragmentations ions were generated from but 1-ene, cis-and trans- but-2-ene, 2-methylpropene, methylcyclopropane and cyclobutane. Forward and reverse activation energies for the above reactions have been estimated and daughter ion structures proposed. The pathway for the consecutive reaction which generates the metastable peak (m/e 56 → m/e 53) is proposed to be Observations on metastable peaks for fourteen assorted daughter ion fragmentations are also presented and the thermochemistry and daughter ion structures for some of the reactions are discussed. Metastable peaks for the fragmentation of ions generated by field ionization are also described.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210120704
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  • 3
    Electronic Resource
    Electronic Resource
    Substituent effects in mass spectra of monosubstituted benzils (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 10 (1975), S. 295-312 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of a series of thirteen m- and p-substituted benzils have been determined at several ionising voltages below 20 eV and at 70 eV. At ionising voltages up to 5 eV above the ionisation potentials the benzil molecular ions decompose entirely by two pathways to give substituted and unsubstituted benzoyl ions. Fractional intensities of the molecular ion (FM), substituted (FX) and unsubstituted (FH) benzoyl ions were obtained for each benzil as a function of energy from measured ionisation efficiency curves, and ionisation and appearance potentials for all major ions determined from the ionisation efficiency curves by a semilogarithmic method. Various correlations of ion intensity and energy parameters with δ+ and δ constants are examined; these are generally poor. Fair correlations are obtained between log (FX/FH) or (AP(XC6H4CO)+ - AP(C6H5CO)+) and δ or δ+, and these are interpreted in terms of the expected effect of substituents on the stabilities of the product ions in the decompositions. A good correlation is observed between log (FX/FH) and AP(XC6H4CO)+ · AP(XC6H5CO)+; this suggests that substituents affect FX/FH mainly by changing the activation energies for the competing decompositions of the molecular ions. The competitive shift has a marked effect on these appearance potentials so that in this system AP - IP is not a good measure of the activation energy for the primary decompositions.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210100408
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