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  • 1
    Electronic Resource
    Electronic Resource
    One medicine: The dynamic relationship between animal and human medicine in history and at present (1998)
    Springer
    Agriculture and human values 15 (1998), S. 115-120 
    Details
    ISSN: 1572-8366
    Keywords: Medicine ; Veterinary medicine ; Public health ; Epidemiology ; Comparative medicine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The relation and collaboration of human and animal medicine had its ups and downs throughout history. The interaction between these two disciplines has been especially fruitful in the broad areas of patho-physiology and of epidemiology. An exploration of the interaction between the two disciplines, using historical and contemporary examples in comparative medicine, zoonoses, zooprophylaxis, and human-animal bond, reveals that a better understanding of animal and human disease, as well as societal changes such as interest in non-conventional medicine, are leading to a broader concept of one medicine that includes animal and human medicine as well as social and other sciences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007478809782
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Multidrug resistance in lactic acid bacteria: molecular mechanisms and clinical relevance (1999)
    Springer
    Antonie van Leeuwenhoek 76 (1999), S. 347-352 
    Details
    ISSN: 1572-9699
    Keywords: ABC transporter ; drug binding sites ; drug efflux ; membrane protein ; secondary transporter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The active extrusion of cytotoxic compounds from the cell by multidrug transporters is one of the major causes of failure of chemotherapeutic treatment of tumor cells and of infections by pathogenic microorganisms. The secondary multidrug transporter LmrP and the ATP-binding cassette (ABC) type multidrug transporter LmrA in Lactococcus lactis are representatives of the two major classes of multidrug transporters found in pro- and eukaryotic organisms. Therefore, knowledge of the molecular properties of LmrP and LmrA will have a wide significance for multidrug transporters in all living cells, and may enable the development of specific inhibitors and of new drugs which circumvent the action of multidrug transporters. Interestingly, LmrP and LmrA are transport proteins with very different protein structures, which use different mechanisms of energy coupling to transport drugs out of the cell. Surprisingly, both proteins have overlapping specificities for drugs, are inhibited by t he same set of modulators, and transport drugs via a similar transport mechanism. The structure-function relationships that dictate drug recognition and transport by LmrP and LmrA will represent an intriguing new area of research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1002033923510
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    Paper (German National Licenses)
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