Publikationsdatum:
1982-12-24
Beschreibung:
Evidence for the binding of 5,5-diphenylhydantoin and glucocorticoids to a common receptor is presented for pulmonary and hepatic cytosols and thymocytes of A/J female mice. The 5,5-diphenylhydantoin-protein complex is absorbed by DNA cellulose, and is incorporated into nuclei, 5,5-Diphenylhydantoin, like glucocorticoids, inhibits the production of prostaglandins in thymocytes. Thus a common receptor is probably responsible for the inhibitory and teratogenic effects of these drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Katsumata, M -- Gupta, C -- Baker, M K -- Sussdorf, C E -- Goldman, A S -- DE-4622/DE/NIDCR NIH HHS/ -- DE-5041/DE/NIDCR NIH HHS/ -- DE-5592/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1313-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6897299" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
6-Ketoprostaglandin F1 alpha/biosynthesis
;
Animals
;
Binding, Competitive
;
Cleft Palate/chemically induced
;
Dexamethasone/metabolism
;
Liver/metabolism
;
Lung/metabolism
;
Mice
;
Phenytoin/*metabolism
;
Prostaglandins/*biosynthesis
;
Receptors, Glucocorticoid/*metabolism
;
Receptors, Steroid/*metabolism
;
Thromboxane B2/biosynthesis
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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