ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • *Trans-Activators  (2)
  • *Movement  (1)
  • American Association for the Advancement of Science (AAAS)  (3)
  • National Academy of Sciences
  • 1995-1999  (2)
  • 1980-1984  (1)
  • 1965-1969
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (3)
  • National Academy of Sciences
Years
  • 1995-1999  (2)
  • 1980-1984  (1)
  • 1965-1969
Year
  • 1
    facet.materialart.
    Unknown
    Teratogen-mediated inhibition of target tissue response to Shh signaling (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-11
    Description: Veratrum alkaloids and distal inhibitors of cholesterol biosynthesis have been studied for more than 30 years as potent teratogens capable of inducing cyclopia and other birth defects. Here, it is shown that these compounds specifically block the Sonic hedgehog (Shh) signaling pathway. These teratogens did not prevent the sterol modification of Shh during autoprocessing but rather inhibited the response of target tissues to Shh, possibly acting through the sterol sensing domain within the Patched protein regulator of Shh response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cooper, M K -- Porter, J A -- Young, K E -- Beachy, P A -- New York, N.Y. -- Science. 1998 Jun 5;280(5369):1603-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9616123" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/etiology ; Animals ; Cell Membrane/metabolism ; Central Nervous System/drug effects/*embryology/metabolism ; Chick Embryo ; Cholesterol/biosynthesis/*metabolism ; Culture Techniques ; DNA-Binding Proteins/biosynthesis ; Endoplasmic Reticulum/metabolism ; Hedgehog Proteins ; Hepatocyte Nuclear Factor 3-beta ; Holoprosencephaly/chemically induced ; Homeodomain Proteins/biosynthesis ; LIM-Homeodomain Proteins ; Membrane Proteins/metabolism ; Muscle Proteins/biosynthesis ; Nerve Tissue Proteins/biosynthesis ; Nuclear Proteins/biosynthesis ; PAX7 Transcription Factor ; Proteins/*metabolism ; Receptors, Cell Surface ; Signal Transduction/drug effects ; Teratogens/*pharmacology ; Tomatine/analogs & derivatives/pharmacology ; *Trans-Activators ; *Transcription Factors ; Triparanol/pharmacology ; Veratrum Alkaloids/*pharmacology ; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Cholesterol modification of hedgehog signaling proteins in animal development (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-10-11
    Description: Hedgehog (Hh) proteins comprise a family of secreted signaling molecules essential for patterning a variety of structures in animal embryogenesis. During biosynthesis, Hh undergoes an autocleavage reaction, mediated by its carboxyl-terminal domain, that produces a lipid-modified amino-terminal fragment responsible for all known Hh signaling activity. Here it is reported that cholesterol is the lipophilic moiety covalently attached to the amino-terminal signaling domain during autoprocessing and that the carboxyl-terminal domain acts as an intramolecular cholesterol transferase. This use of cholesterol to modify embryonic signaling proteins may account for some of the effects of perturbed cholesterol biosynthesis on animal development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Porter, J A -- Young, K E -- Beachy, P A -- New York, N.Y. -- Science. 1996 Oct 11;274(5285):255-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8824192" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cells, Cultured ; Cholesterol/*metabolism ; Dithiothreitol/pharmacology ; Drosophila ; *Drosophila Proteins ; *Embryonic Induction ; Embryonic and Fetal Development ; Hedgehog Proteins ; Humans ; Protein Processing, Post-Translational ; Proteins/genetics/*metabolism ; Signal Transduction ; *Trans-Activators
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Plasticity of motor behavior in monkeys with crossed forelimb nerves (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-22
    Description: Monkeys in which nerves innervating the flexor muscles of the forearm and hand (the ulnar or the median nerve) had been surgically cross-united with the nerve innervating the extensor muscles (the radial nerve), and vice versa, showed excellent (ulnar-radial crosses) to moderate (median-radial crosses) control of movement performance after regeneration. Antagonistic movement responses were seen occasionally, but these were corrected almost immediately. Stimulation of the crossed nerves showed that they had innervated the antagonistic muscle groups. The results reveal the capacity of the primate central nervous system to adapt to gross disturbances imposed on the execution of movements by changes in peripheral innervation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brinkman, C -- Porter, R -- Norman, J -- New York, N.Y. -- Science. 1983 Apr 22;220(4595):438-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836289" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Fingers/physiology ; Forearm/*innervation/physiology ; Hand/innervation/physiology ; Humans ; Macaca fascicularis ; Macaca nemestrina ; Median Nerve/physiology ; *Movement ; *Neuronal Plasticity ; Radial Nerve/physiology ; Thumb/physiology ; Ulnar Nerve/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...