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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of biomedical science 5 (1998), S. 185-191 
    ISSN: 1423-0127
    Keywords: TGF-β ; Bcl-2 ; Apoptosis ; Antioxidative enzyme ; Reactive oxygen species
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Transforming growth factor-β (TGF-β) has been shown to induce apoptosis on normal hepatocytes and hepatoma cells both in vitro and in vivo. However, how the TGF-β induces apoptosis is still not clear. We examined the expression of anti-apoptosis proteins and sensitivity to TGF-β in three well differentiated human hepatoma cell lines. Two TGF-β sensitive cell lines Hep3B and HuH7 totally lacked Bcl-2. In contrast, the TGF-β resistant HepG2 cells expressed a substantial amount of Bcl-2. All three cell lines expressed equal amounts of Bcl-XL, Bcl-XS and Bax. Overexpression of Bcl-2 in Hep3B and HuH7 cells protected them from TGF-β-induced apoptosis. TGF-β treatment increased intracellular peroxide production and suppressed the expression of glutathione-S-transferase in the Hep3B cells, and these effects were partially suppressed by the overexpression of Bcl-2. These results suggest that Bcl-2 may protect cell from TGF-β-F-induced apoptosis by interfering TGF-β generated signals leading to induce reactive oxygen species production.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of superconductivity 9 (1996), S. 73-76 
    ISSN: 1572-9605
    Keywords: High-T c superconductor ; pancake coil ; mu metal ; magnetic field
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract High permeability ring-shaped mu metal sheets have been used to enhance magnetic fields in the bore of Bi-based high-T c superconducting coils. The central magnetic fieldB 0, generated by pancake coils placed between mu metal sheets, was measured at liquid nitrogen temperature 77 K. The increasing rate (IR) of the central magnetic fieldB 0 for single pancake coils was from 15 to 63% by using a 0.1 mm thick mu metal sheet. IR was decreased when the originalB 0 value increased. The thickness of mu metal sheets also affected IR. It was found that IR increased as the number of mu metal sheets was increased. In a test double-pancake coil IR reached 101%,B 0 was enhanced from 902 to 1815 G, when the total thickness of mu metal sheets on the top and bottom surface of the coil was 2.0 mm. These results indicate that the well-designed high-permeability materials can significantly enhance the magnetic fields generated by high-T c superconducting coils and magnets.
    Type of Medium: Electronic Resource
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