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  • 1
    Electronic Resource
    Electronic Resource
    Thickness effects of CCT specimens (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 623-635 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: First, the three-dimensional elasto-plastic analyses of 1CT and 18 mm thick CCT specimens are carried out by using the finite element method, and the thickness effects of both specimens are studied. In elastic states, there is no significant difference between the CT and CCT specimen in the distribution of the J-integral along the straight or curved crack front. However, in elasto-plastic states, quite the contrary tendency is obtained in the distributions of J x and COD along the curved crack front for both specimens. Secondly, elasto-plastic analyses are carried out for CCT specimens of four kinds of thickness (B = 200, 18, 6 and 4 mm). The distributions of the J-integral along the crack front are obtained and compared. Finally, the availability of the JR value is examined, which is evaluated from the load versus displacement curve by using Rice's formula.
    Additional Material: 22 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220308
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  • 2
    Electronic Resource
    Electronic Resource
    A mesh re-zoning technique for finite element simulations of metal forming processes (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 219-228 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Based on some fundamental properties of finite element approximations, a mesh re-zoning scheme is proposed for finite element simulations of metal forming problems. It is demonstrated that this technique is indispensable in analysing many difficult forming processes, especially when there exist corners or very irregular shapes on the boundaries. The algorithm is tested by a backward extrusion process and direct extrusion through a square die.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230206
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  • 3
    Electronic Resource
    Electronic Resource
    APPLICATION OF TOPOLOGICAL OPTIMIZATION TECHNIQUES TO STRUCTURAL CRASHWORTHINESS (1996)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 39 (1996), S. 1383-1403 
    Details
    ISSN: 0029-5981
    Keywords: crashworthiness ; homogenization ; topology design ; automotive structure optimization ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The topological optimization of components to maximize crash energy absorption for a given volume is considered. The crash analysis is performed using a DYNA3D finite element analysis. The original solid elements are replaced by ones with holes, the hole size being characterized by a so-called density (measure of the reduced volume). A homogenization method is used to find elastic moduli as a function of this density. Simpler approximations were developed to find plastic moduli and yield stress as functions of density.Optimality criteria were derived from an optimization statement using densities as the design variables. A resizing algorithm was constructed so that the optimality criteria are approximately satisfied. A novel feature is the introduction of an objective function based on strain energies weighted at specified times. Each different choice of weighting factors leads to a different structure, allowing a range of design possibilities to be explored.The method was applied to an automotive body rear rail. The original design and a new design of equal volume with holes were compared for energy absorption.
    Additional Material: 25 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    NUMERICAL SIMULATION OF THE PHENOMENA DUE TO THE PASSING-BY OF TWO BODIES USING THE UNSTEADY BOUNDARY ELEMENT METHOD (1996)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 23 (1996), S. 445-454 
    Details
    ISSN: 0271-2091
    Keywords: boundary element method ; unsteady aerodynamic force ; relative motion ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In this paper a numerical analysis was made to investigate the aerodynamic forces surrounding two bodies in relative motion in a fluid at rest in three dimensions. The unsteady boundary element method was employed in the numerical calculations. This method is very convenient for obtaining an approximate expression of the velocity potential, especially for practical use. The passing-by of two spheres in an incompressible perfect fluid which extends to infinity is treated by the present method. The resultant pressure coefficients on two spheres passing each other in opposite directions are calculated and discussed numerically. Numerical examples are presented to show the validity of the present method. The method is also applied to the calculation of the passing-by of two trains in an open area in order to investigate its applicability.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Topology optimization of compliant mechanisms using the homogenization method (1998)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 42 (1998), S. 535-559 
    Details
    ISSN: 0029-5981
    Keywords: optimal design ; topology optimization ; compliant mechanisms ; homogenization method ; mutual energy ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A procedure to obtain a topology of an optimal structure considering flexibility is presented. The methodology is based on a mutual energy concept for formulation of flexibility and the homogenization method. A multi-objective optimization problem is formulated as an application of compliant mechanism design. Some examples of the design of compliant mechanisms for plane structures are presented. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Adaptive methods to solve free boundary problems of flow through porous media (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 11 (1987), S. 17-31 
    Details
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: Grid adaptive methods combined with domain adaptation are discussed for two-dimensional seepage flow problems with free boundaries through porous media. Examples of grid and domain adaptive methods are presented to demonstrate several ways to predict grids and shapes of free boundaries using an iterative scheme. Finally, the combined adaptive methods are applied to obtain smooth non-oscillatory shape of a free boundary of seepage flow through non-homogeneous porous media.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nag.1610110103
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  • 7
    Electronic Resource
    Electronic Resource
    Numerical simulation of the ground effect using the boundary element method (1997)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 25 (1997), S. 1043-1056 
    Details
    ISSN: 0271-2091
    Keywords: ground effect ; boundary element method ; unsteady aerodynamic force ; relative motion ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: As is well known, the lift of a wing passing over the ground becomes larger than that of a wing in a finite air field because of the ground effect. Owing to its special aerodynamic characteristics and applications, the problem of the ground effect has become increasingly common. In this paper some investigations were conducted to calculate the unsteady aerodynamic forces for long and short ground plates by means of boundary element techniques. In order to calculate the pressure variation on a long ground plate, the steady boundary element method was used. However, when using a short ground plate, the boundary element method was modified to treat the unsteady aerodynamic phenomena. Experimental studies were also made for both ground plates to confirm the validity of the numerical results. At low angles of attack the qualitative behaviour of the unsteady aerodynamic pressure on both ground plates was well predicted by the boundary element methods and qualitative agreement is found between the calculated and measured results. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 17 Ill.
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  • 8
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    Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-28
    Description: DFN3, an X chromosome-linked nonsyndromic mixed deafness, is caused by mutations in the BRN-4 gene, which encodes a POU transcription factor. Brn-4-deficient mice were created and found to exhibit profound deafness. No gross morphological changes were observed in the conductive ossicles or cochlea, although there was a dramatic reduction in endocochlear potential. Electron microscopy revealed severe ultrastructural alterations in cochlear spiral ligament fibrocytes. The findings suggest that these fibrocytes, which are mesenchymal in origin and for which a role in potassium ion homeostasis has been postulated, may play a critical role in auditory function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Minowa, O -- Ikeda, K -- Sugitani, Y -- Oshima, T -- Nakai, S -- Katori, Y -- Suzuki, M -- Furukawa, M -- Kawase, T -- Zheng, Y -- Ogura, M -- Asada, Y -- Watanabe, K -- Yamanaka, H -- Gotoh, S -- Nishi-Takeshima, M -- Sugimoto, T -- Kikuchi, T -- Takasaka, T -- Noda, T -- New York, N.Y. -- Science. 1999 Aug 27;285(5432):1408-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, The Cancer Institute, Japanese Foundation for Cancer Research, 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 170-8455, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10464101" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cochlear Duct/*metabolism/pathology ; *DNA-Binding Proteins ; Deafness/genetics/*metabolism/pathology ; Ear, Inner/metabolism/pathology ; Ear, Middle/pathology ; Endolymph/metabolism ; Evoked Potentials, Auditory, Brain Stem ; Female ; Gene Expression ; Gene Targeting ; Genetic Linkage ; In Situ Hybridization ; Ion Transport ; Male ; Membrane Potentials ; Mice ; Mice, Inbred C57BL ; Mutagenesis ; *Nerve Tissue Proteins ; POU Domain Factors ; Potassium/*metabolism ; Transcription Factors/genetics/*metabolism ; X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1 (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-06-13
    Description: Extracellular levels of the excitatory neurotransmitter glutamate in the nervous system are maintained by transporters that actively remove glutamate from the extracellular space. Homozygous mice deficient in GLT-1, a widely distributed astrocytic glutamate transporter, show lethal spontaneous seizures and increased susceptibility to acute cortical injury. These effects can be attributed to elevated levels of residual glutamate in the brains of these mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tanaka, K -- Watase, K -- Manabe, T -- Yamada, K -- Watanabe, M -- Takahashi, K -- Iwama, H -- Nishikawa, T -- Ichihara, N -- Kikuchi, T -- Okuyama, S -- Kawashima, N -- Hori, S -- Takimoto, M -- Wada, K -- New York, N.Y. -- Science. 1997 Jun 13;276(5319):1699-702.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Degenerative Neurological Diseases, National Institute of Neuroscience, Kodaira, Tokyo 187, Japan. tanaka@ncnaxp.ncap.go.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9180080" target="_blank"〉PubMed〈/a〉
    Keywords: ATP-Binding Cassette Transporters/genetics/*metabolism ; Amino Acid Transport System X-AG ; Animals ; Biological Transport ; Brain/*metabolism/pathology ; Brain Injuries/*metabolism/pathology ; Electroencephalography ; Epilepsy/*metabolism/pathology ; Gene Targeting ; Glutamic Acid/*metabolism ; Hippocampus/metabolism/pathology ; Mice ; Mice, Inbred C57BL ; Nerve Degeneration ; Pyramidal Cells/pathology/physiology ; Synapses/metabolism ; Synaptic Transmission
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Interferon inhibits the establishment of competence in Go/S-phase transition (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-07-18
    Description: Addition of mouse interferon-alpha/beta (IFN) to confluent, quiescent BALB/c 3T3 (clone A31) mouse fibroblasts resulted in a block or delay in serum-induced activation of the cell cycle. It was necessary to add IFN within 6 hours after serum stimulation to inhibit nuclear labeling with [3H]thymidine. This is consistent with the time required for platelet-derived growth factor (PDGF) to induce cells to become competent to respond to additional growth factors present in platelet-poor plasma. Simultaneous addition of IFN with PDGF inhibited the PDGF-induced synthesis of a 29-kilodalton and a 35-kilodalton protein that normally occurs within 1 hour after PDGF addition. IFN also suppressed the general increase in protein synthesis that occurs by the fifth hour after PDGF addition. These results show that IFN antagonizes the action of PDGF, thereby interfering with the activation of Go cells for G1 traverse and S-phase entry.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, S L -- Kikuchi, T -- Pledger, W J -- Tamm, I -- CA 18213/CA/NCI NIH HHS/ -- CA 18608/CA/NCI NIH HHS/ -- CA 42713/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1986 Jul 18;233(4761):356-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3726533" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood ; Cell Cycle/*drug effects ; Electrophoresis, Polyacrylamide Gel ; Interferon Type I/*pharmacology ; Interphase ; Mice ; Mice, Inbred BALB C ; Molecular Weight ; Platelet-Derived Growth Factor/pharmacology ; Protein Biosynthesis ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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