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  • Life and Medical Sciences  (766)
  • ASTRONOMY  (401)
  • 1995-1999  (319)
  • 1985-1989  (828)
  • 1935-1939  (20)
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  • 1
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    CGRO/OSSE observations of the Cassiopeia A Supernova remnant (1995)
    In:  Other Sources
    Details
    Publication Date: 2019-08-28
    Description: Cassipeia A, the youngest known supernova remnant in the Galaxy and a strong radio and X-ray source, was observed by OSSE 1992 July 16-August 6. Its close distance (approximately 3 kpc) and its young age (approximately 300 yr) make Cas A the best candidate among known supernova remnants for detecting Ti-44 gamma-ray lines. We find no evidence of emission at 67.9 keV, 78.4 keV, or 1.157 MeV, the three strongest Ti-44 decay lines. From simultaneous fits to the three lines our 99% confidence upper limit to the flux in each line is 5.5 x 10(exp -5) gamma/sq cm s. We also report upper limits for the 4.44 MeV C-12 nuclear de-excitation line, which could be produced by interactions of acclerated particles in the supernova remnant, and for the hard X-ray continuum.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 444; 1; p. 244-250
    Format: text
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular interactions between fibronectin and integrins during mouse blastocyst outgrowth (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 41 (1995), S. 435-448 
    Details
    ISSN: 1040-452X
    Keywords: Peri-implantation embryogenesis ; Trophoblast cells ; Recombinant proteins ; Integrins ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: To investigate the mechanism of trophoblast adhesion to fibronectin, we cultured blastocysts in serum-free medium on proteolytic fibronectin fragments containing its major functional domains, and localized fibronectin-binding integrins in outgrowing trophoblast cells by immunofluorescent staining. Outgrowth comparable to that obtained with intact fibronectin was observed using a 120 kD chymotryptic fragment containing the central cell-binding domain (FN-120) and the Arg-Gly-Asp (RGD) recognition sequence. A 40 kD COOH-terminal chymotryptic fragment of fibronectin containing both a heparin-binding region and an alternate (non-RGD) cell-binding site was inactive in supporting trophoblast adhesion. Three synthetic peptides derived from the heparin-binding domain, including the CS1 alternate cell-binding site, were also unable to promote trophoblast cell adhesion. A 75 kD recombinant protein, ProNectin F, containing 13 copies of the cell recognition epitope of fibronectin, Val-Thr-Gly-Arg-Gly-Asp-Ser-Pro-Ala-Ser, vigorously supported blastocyst outgrowth. Blastocyst outgrowth was not significantly different when surfaces were precoated with cellular fibronectin, which contains an alternatively spliced type III repeat and is the form actually encountered in vivo. Several putative fibronectin receptors were localized in trophoblast outgrowths by immunofluorescent labeling. Antibodies reactive with integrin subunits α3, α5, αllb, αv, β1 and β3, but not α4, all bound to trophoblast cells. Antibodies raised against either the β1 or β3 integrin subunits significantly inhibited fibronectin-mediated outgrowth. These findings demonstrate the key role of the central cell-binding domain of fibronectin in trophoblast adhesion, and suggest four RGD-binding integrins, α3β1, α5β1, αllbβ3, and αvβ3, that could mediate trophoblast adhesion in vitro and may play an important role during implantation. © 1995 Wiley-Liss, Inc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080410406
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  • 3
    Electronic Resource
    Electronic Resource
    Detection and location of amphiregulin and Cripto-1 expression in the developing postnatal mouse mammary gland (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 41 (1995), S. 277-286 
    Details
    ISSN: 1040-452X
    Keywords: EGF-like ligands ; Postnatal development ; RT-PCR ; Immunocytochemistry ; Immunoblotting ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Amphiregulin (Ar) and Cripto-1 (Cr-1) are growth promoting peptides that share amino acid sequence homology with epidermal growth factor (EGF). The present study examined Ar and Cr-1 mRNA and protein expression during various stages of C57BL/6 mouse mammary morphogenesis. Reverse transciption-polymerase chain reaction (RT-PCR) was used to detect transcripts for Ar and Cr-1 at all stages of mammary development. Immunocytochemical (ICC) localization demonstrated that in virgin 4-week to mature 12-week-old mouse fourth inguinal mammary gland, Ar and Cr-1 are expressed in the stromal cells, luminal epithelial cells, and myoepithelial cells of the branching ducts. Ar, and to lesser extent Cr-1, were also found in the epithelial cap cells and in the luminal epithelial cells of the advancing terminal end bud (TEB) from virgin 4-week and 6-week-old mice. Western blot analysis demonstrated that both Ar (28 and 26 kDa) and Cr-1 (90, 67, 56, and 21 kDa) proteins are expressed in virgin, 13.5 day midpregnant and in the 14 day lactating mammary gland. In addition, Ar and Cr-1 are associated with developing alveolar structures as determined by ICC. These results imply that together with EGF and transforming growth factor alpha (TGFα), Ar and Cr-1 may play salient roles as modifiers in the morphogenesis and differentiation of the mammary gland. © 1995 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080410302
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacological profile of the substituted beta-lactam L-659,286: A member of a new class of human PMN elastase inhibitors (1989)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 39 (1989), S. 47-53 
    Details
    ISSN: 0730-2312
    Keywords: elastase inhibitors ; β-lactams ; lung damage ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Human polymorphonuclear leukocyte elastase (PMN elastase) is inhibited by L-659, 286 (7α-methoxy-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triaz-in-3-yl)thio]methyl]-5-thia-1-aza-6R-bicyclo [4.2.O]oct-2-ene-2-pyrrolidine carboxamide-5,-dioxide) with a Ki of 0.4 μM. This inhibition is time-dependent, rapid, and only slowly reversible, with a t1/2 of 〉 3 days at 25°C. L-659, 286 is also highly selective for PMN elastase, as it does not inhibit thrombin, trypsin, papain, plasmin, chymotrypsin, or cathepsin G. L-659, 286 administered intratracheally inhibits lung damage caused by administration via the same route of human PMN elastase into hamsters. In marmosets, L-659, 286 is cleared from blood very rapidly after an intravenous injection but is recovered in bronchoalveolar lavage fluid for several hours after intratracheal administration.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240390106
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  • 5
    Electronic Resource
    Electronic Resource
    Plant tubulin genes: Structure and differential expression during development (1987)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 8 (1987), S. 435-460 
    Details
    ISSN: 0192-253X
    Keywords: tubulin genes ; microtubules ; Arabidopsis thaliana ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Microtubules are important components of the cytoskeleton of plant cells and play key roles in plant growth and morphogenesis. Recent molecular studies have begun to elucidate the structure and expression of plant genes coding for the major components of microtubules, α- and β-tubulin. Tubulin amino acid sequences deduced from the DNA sequences of eight higher plant tubulin genes are 79-87% homologous with constitutively expressed mammalian tubulins. The genome of the model plant system Arabidopsis thaliana contains four dispersed α-tubulin sequences and at least seven β-tubulin sequences, only two of which appear to be linked. Of the five A. thaliana genes whose expression has been analyzed, the transcripts of one α-tubulin and one β-tubulin gene are constitutively expressed in roots, leaves, and flowers. A second α-tubulin gene is expressed predominately in flowers; the transcripts of the second and third β-tubulin genes are found predominately in leaves or in roots, respectively.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020080511
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  • 6
    Electronic Resource
    Electronic Resource
    Pulsed magnetic field from video display terminals enhances teratogenic effects of cytosine arabinoside in mice (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 16 (1995), S. 70-74 
    Details
    ISSN: 0197-8462
    Keywords: video display terminals ; embryogenesis ; teratology ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Eighty-nine Swiss Webster mice were randomly divided into four groups: a control group, a pulsed magnetic field (PMF) group, a cytosine arabinoside (ara-C, a teratogen) group, and, a combined PMF + ara-C group. Mice in the PMF and PMF + ara-C groups were irradiated with a PMF (a sawtooth waveform with 52 μs rise time, 12 μs decay time, and 15.6 kHz frequency) at a peak magnetic flux density of 40 μT for 4 hours daily on days 6-17 of gestation. The mice in the ara-C and the PMF + ara-C groups were injected intraperitoneally on day 9 of gestation with 10 mg/kg of ara-C. The incidence of resorption and dead fetuses was not affected by PMF but was increased by ara-C injection. The malformation incidence of cleft palate (CP) and/or cleft lip (CL) was significantly higher in all three of the treated groups than in the control group (P 〈 0.05). If, however, statistical analyses had been done on litters rather than on individual fetuses, they would show that the incidence of CP and/or CL in the PMF group is not significantly greater than that in the control group. A significantly higher incidence of CP and/or CL was found in the PMF + ara-C group (49%) than the ara-C alone group (26.1%). These data suggest that PMF might enhance the development of ara-C-induced CP and/or CL. The incidence of minor variations in skeletal development, including reduction of skeletal calcification and loss of skeleton, was not statistically significant in the PMF group. However, it was higher in the two ara-C-treated groups, and there was no significant difference between the ara-C alone group and the ara-C + PMF group. From these results it is concluded that the very weak embryotoxic effects of PMF exposure may be revealed and enhanced in combination with a teratogenic agent. © 1995 Wiley-Liss, Inc.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250160113
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  • 7
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    Observations of the J = 10 manifold of the pure rotational band of phosphine on Saturn (1986)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: Saturn was observed in the vicinity of the J = 10 manifold of the pure rotational band of phosphine on 1984 July 10 and 12 from NASA's Kuiper Airborne Observatory with the facility far-infrared cooled grating spectrometer. On each night observations of the full disk plus rings were made at 4 to 6 discrete wavelengths which selectively sampled the manifold and the adjacent continuum. The previously reported detection of this manifold is confirmed. After subtraction of the flux due to the rings, the data are compared with disk-averaged models of Saturn. It is found that PH3 must be strongly depleted above the thermal inversion (approx. 70 mbar). The best fitting models consistent with other observational constaints indicate that PH3 is significantly depleted at even deeper atmospheric levels ( or = 500 mbar), implying an eddy diffusion coefficient for Saturn of 10 to the 4 cm sq/sec.
    Keywords: ASTRONOMY
    Type: NASA-TM-86851 , REPT-85434 , PREPRINT-SER-042 , NAS 1.15:86851
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 8
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    Fast spectroscopic variations on rapidly-rotating, cool dwarfs. 3: Masses of circumstellar absorbing clouds on AB Doradus (1989)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: New time-resolved H alpha, Ca II H and K and Mg II h and k spectra of the rapidly-rotating K0 dwarf star AB Doradus (= HD 36705). The transient absorption features seen in the H alpha line are also present in the Ca II and Mg II resonance lines. New techniques are developed for measuring the average strength of the line absorption along lines of sight intersecting the cloud. These techniques also give a measure of the projected cloud area. The strength of the resonance line absorption provides useful new constraints on the column densities, projected surface areas, temperatures and internal turbulent velocity dispersions of the circumstellar clouds producing the absorption features. At any given time the star appears to be surrounded by at least 6 to 10 clouds with masses in the range 2 to 6 x 10(exp 17) g. The clouds appear to have turbulent internal velocity dispersions of order 3 to 20 km/s, comparable with the random velocities of discrete filamentary structures in solar quiescent prominences. Night-to-night changes in the amount of Ca II resonance line absorption can be explained by changes in the amplitude of turbulent motions in the clouds. The corresponding changes in the total energy of the internal motions are of order 10(exp 29) erg per cloud. Changes of this magnitude could easily be activated by the frequent energetic (approximately 10(exp 34) erg) x ray flares seen on this star.
    Keywords: ASTRONOMY
    Type: NASA-CR-186563 , NAS 1.26:186563
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  • 9
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    Study of dust in the vicinity of Dione using the Voyager 1 plasma wave instrument (1995)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: The flyby of Voyager 1 at Saturn yielded the detection of a large variety of plasma waves, for example, chorus, hiss, and electron cyclotron harmonics. Just before the outbound equator crossing, the Voyager 1 plasma wave instrument detected a strong, well-defined low-frequency enhancement in signal levels. Initially, it was thought that this enhancement was due to plasma waves, but more recently it was suggested that dust impacts might be at least partial contributors. In this report we present evidence that dust impacts are partly responsible for the low-frequency enhancement. A new method of analysis which relies mainly on the 16-channel spectrum analyzer has been used to derive the dust impact rate. The available wideband waveform observations (which have been used previously to study dust impacts) were useful for calibrating the impact rate from the spectrum analyzer data. The mass and hence size of the dust particles were also obtained by analyzing the response of the plasma wave spectrum and analyzer. The results show that the region sampled by Voyager 1 is populated by dust particles that have rms masses of up to a few times 10(exp -11) g and sizes of up to a few microns. The dust particle number density is of the order of 10(exp -3)/cu m. The optical depth of the region sampled by the spacecraft is approximately 10(exp -6). The particle population is centered at 2470 (+/- 150) km south of the equatorial plane and has a north-south FWHM (full-width, half-maximum) thickness of 4130 (+/- 450) km. The dust may be part of the E ring or a localized ringlet assoicated with Dione.
    Keywords: ASTRONOMY
    Type: Journal of Geophysical Research (ISSN 0148-0227); 100; A2; p. 1811-1822
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  • 10
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    Research in planetary astronomy and operation of the 2.2-meter telescope (1986)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: The turn-around in the secular change in brightness of Pluto was detected, the planet is now beginning to brighten. The spectral signature was found of an ammonia bearing compound in the surface ices of Europa. Specific Io volcanic hotspots were detected from infrared photometry of the mutual events of the Jovian satellites. The polarized emission from the volcanic hotspots on Io was discovered and the locations of those hotspots were determined. The orbit of Charon was refined from speckle observations of the Pluto-Charon system. The spectral properties of liquid nitrogen-methane mixtures with reference to the infrared spectrum of Triton were studied. Major progress was made in modeling asteroid lightcurves from a modern theory of photometric properties of the asteroid surfaces. Several additional olivine-rich asteroids from near-infrared spectrophotometry were discovered. Important photometric, spectroscopic, narrow-band imaging data on Comet P/Halley was acquired, along with Schmidt photographs of Comet P/Halley and its tail.
    Keywords: ASTRONOMY
    Type: NASA, Washington Reports of Planetary Astronomy, 1985; p 28-31
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