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  • Wiley-Blackwell  (10)
  • American Association for the Advancement of Science (AAAS)  (1)
  • 1995-1999  (5)
  • 1985-1989  (3)
  • 1965-1969  (3)
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Keywords
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  • 1
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    Physical mapping of a translocation breakpoint in neurofibromatosis (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-06-02
    Description: The gene for von Recklinghausen neurofibromatosis (NF1), one of the most common autosomal-dominant disorders of humans, was recently mapped to chromosome 17 by linkage analysis. The identification of two NF1 patients with balanced translocations that involved chromosome 17q11.2 suggests that the disease can arise by gross rearrangement of the NF1 locus, and that the NF1 gene might be identified by cloning the region around these translocation breakpoints. To further define the region of these translocations, a series of chromosome 17 Not I-linking clones has been mapped to proximal 17q and studied by pulsed-field gel electrophoresis. One clone, 17L1 (D17S133), clearly identifies the breakpoint in an NF1 patient with a t(1;17) translocation. A 2.3-megabase pulsed-field map of this region was constructed and indicates that the NF1 breakpoint is only 10 to 240 kilobases away from 17L1. This finding prepares the way for the cloning of NF1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fountain, J W -- Wallace, M R -- Bruce, M A -- Seizinger, B R -- Menon, A G -- Gusella, J F -- Michels, V V -- Schmidt, M A -- Dewald, G W -- Collins, F S -- NS22224/NS/NINDS NIH HHS/ -- NS23410/NS/NINDS NIH HHS/ -- NS23427/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1989 Jun 2;244(4908):1085-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, University of Michigan, Ann Arbor 48109.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2543076" target="_blank"〉PubMed〈/a〉
    Keywords: *Chromosome Mapping ; *Chromosomes, Human, Pair 17 ; Cloning, Molecular ; DNA Restriction Enzymes ; Electrophoresis ; Female ; Genetic Linkage ; Humans ; Hybrid Cells ; Male ; Neurofibromatosis 1/*genetics ; *Translocation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
    Electronic Resource
    Electronic Resource
    Design and Synthesis of 5-Lipoxygenase Inhibitors (1988)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 71 (1988), S. 1156-1176 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Based on the substrate specificity for 5-lipoxygenase and the known stereochemical course of the reaction, a hypothetical model of the enzyme active site was developed and used to design 2 types of selective inhibitors of 5-lipoxygenase. Both inhibitor types used aromatic rings in place of (Z)-olefins of the substrate and were designed to mimic the nonpolar end of arachidonic acid. One inhibitor type used a carboxylic-acid interaction with the O-binding centre of the enzyme in analogy with known cyclooxygenase inhibitors, whereas a second type employed a hydroxylamine function to interact with a presumed tyrosine or cysteinyl radical predicted to be in the enzyme active site. Selective 5-lipoxygenase inhibitors were 7-(hexyloxy) naphthalene-2-acetic acid (1) and N-methyl;-N(7-propoxynaphthalene-2-ethyl)hydroxylamine (2). Structure-activity relationships for both types of inhibitors are discussed.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19880710528
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  • 3
    Electronic Resource
    Electronic Resource
    Diffusion coefficients of gallium(III) in potassium nitrate and potassium chloride supporting electrolytes (1997)
    Weinheim : Wiley-Blackwell
    Electroanalysis 9 (1997), S. 231-234 
    Details
    ISSN: 1040-0397
    Keywords: Diffusion coefficients ; Gallium ; Mass transport ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The diffusion coefficient values of GaIII in potassium nitrate and potassium chloride supporting electrolytes have been obtained polarographically. The half-wave potential, E1/2, and E3/4-E1/4 values have also been determined. The E3/4 - E1/4 values confirm the irreversibility of GaIII reduction in KNO3 and KCl electrolytes.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140090308
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  • 4
    Electronic Resource
    Electronic Resource
    Voltammetry and LCEC of isoflavones (1997)
    Weinheim : Wiley-Blackwell
    Electroanalysis 9 (1997), S. 796-799 
    Details
    ISSN: 1040-0397
    Keywords: Isoflavones ; Cyclic voltammetry ; High-performance liquid chromatography ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: This study provides electrochemical and LCEC determination for three of the most abundant and most important isoflavones, Biochanin A, formononetin, and genistein. Cyclic voltammetry and pH-potential diagrams show that the isoflavones undergo pH-dependent irreversible oxidations. The LCEC determination of the isoflavones has been optimized for mobile phase composition and detection potential. Sub-nanogram detection limits have been achieved.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140091013
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  • 5
    Electronic Resource
    Electronic Resource
    Evaluation of diffusion coefficients of metallic ions in aqueous solutions (1996)
    Weinheim : Wiley-Blackwell
    Electroanalysis 8 (1996), S. 307-313 
    Details
    ISSN: 1040-0397
    Keywords: Diffusion coefficients ; Diffusion ; Metallic ions ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Many techniques are available for the determination of diffusion coefficients of ions in aqueous solutions. A review of classical and modern techniques is presented. Non-electrochemical methods are discussed briefly. Electrochemical methods reviewed include chronoamperometry, chronopotentiometry, polarography, and hydrodnamics. Selected values of the diffusion coefficients determined by these electrochemical methods of the metallic ions AgI, BiIII, CdII, CuII InIII, PbII, TlI, and ZnII are presented.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140080402
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  • 6
    Electronic Resource
    Electronic Resource
    Electrochemistry of hexacoordinate silicon(IV) porphyrin complexes (1997)
    Weinheim : Wiley-Blackwell
    Electroanalysis 9 (1997), S. 1273-1277 
    Details
    ISSN: 1040-0397
    Keywords: Cyclic voltammetry ; Porphyrins ; Silicon ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Cyclic voltammetry was used to characterize the oxidation-reduction behavior of a series of novel hexacoordinate silicon(IV) porphyrin complexes. Each (Por)SiX2 [Por = the dianions of the porphyrins: tetrakis(p-tolyl)porphyrin (TTP), tetraphenylporphyrin (TPP), tetrakis(p-trifluoromethylphenyl)porphyrin (TTFP), octaethylporphyrin (OEP), × = F, Cl, O3SCF3] complex undergoes one to two oxidations and one to two reductions, all occurring at the porphyrin ring. No silicon(IV) reduction is observed for any of the porphyrin complexes. The effects of solvent, supporting electrolyte, substituents on the porphyrin ring, axial ligands, certral metal, and ruffling of the porphyrin ring are described.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140091611
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  • 7
    Electronic Resource
    Electronic Resource
    Autoxydation N2-substituierter Methylhydrazine; Beeinflussung der Cu- & Fe-Katalyse durch Proteine, Desoxyribonucleinsäure (DNS) und EDTAÜber die hier mitgeteilten Experimente ist in einem am 6. Dezember 1963 von der Berner Chemischen Gesellschaft gehaltenen Vortrag berichtet worden. (1965)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 48 (1965), S. 656-674 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1. Autoxidation of natulan and other methylhydrazine derivatives has been investigated by WARBURG'S direct manometric method. These compounds are relatively stable in a heavy-metal-free environment at pH 7.0, but are rapidly oxidised if a suitable catalyst is added.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19650480403
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  • 8
    Electronic Resource
    Electronic Resource
    Peroxidbildung bei der Autoxydation N2-substituierter Methylhydrazine (1965)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 48 (1965), S. 1380-1394 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1. Formation of peroxide as produced in autoxidation of N2-substituted methylhydrazine derivatives has been studied with the WARBURG technique. The following methods for its detection have been used: (a) chemical and enzymatic estimation of H2O2, (b) coupled formate oxidation (H14COONa → 14CO2), (c) methemoglobin formation in suspensions of acatalatic red cells as a «biological indicator».
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19650480619
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  • 9
    Electronic Resource
    Electronic Resource
    Amplification of RNA and DNA specific for erb B in unbalanced 1;7 chromosomal translocation associated with myelodysplastic syndrome (1986)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 32 (1986), S. 23-34 
    Details
    ISSN: 0730-2312
    Keywords: EGF receptor ; oncogene ; gene amplification ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Previous work has established the presence of an unbalanced chromosome abnormality [+der(1),t(1;7)(p11;p11)] in some therapy-associated myelodysplastic disorders. Recently the EGF receptor has been found to reside at 7p11. Using a probe specific for erb B oncogene, which encodes a truncated form of the EGF receptor, we examined RNA and DNA derived from bone marrow and peripheral blood mononuclear cells from three patients with myelodysplastic syndromes (MDS) and one with acute lymphocytic leukemia (ALL), all bearing an abnormal clone in their bone marrow with a similar unbalanced 1;7 translocation. DNA-excess slot blot hybridization to 5′-32p-labeled cellular RNA revealed from ten- to thirtyfold enhancement in accumulation of mRNA specific for erb B in both peripheral blood and bone marrow cells of the three MDS patients when compared to normal controls. In addition, enhancement of H-ras mRNA accumulation was detected in some, though expression of other genes such as actin, N-ras, myc, src, B-lym, and 20 other genes was not found to be enhanced. Increased erb B expression was not apparent in mononuclear cells from patients with other hematologic disorders such as chronic lymphocytic leukemia, Hodgkin's disease, or lymphoma. Southern blot analysis of restriction-enzyme-cleaved DNA from three MDS patients with an unbalanced 1;7 translocation revealed that erb B gene was amplified at least twentyfold in peripheral blood white blood cells, while levels of actin hybridization were comparable to those of the controls. No such amplification was evident in the ALL patient. Our data suggest that +der(1),t(1;7)(p11;p11) chromosomal anomalies can be specifically associated with amplification of erb B DNA and RNA sequences.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240320104
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  • 10
    Electronic Resource
    Electronic Resource
    Bicyclische Verbindungen, IV1). Dehydratisierung von tertiären Methyl-bicyclooctanolenHerrn Professor Dr. Eugen Müller zum 60. Geburtstag gewidmet. Wolfgang Kraus. (1965)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 689 (1965), S. 21-39 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Wasserabspaltung aus cis- und trans-2-Methyl-bicyclo[3.2.1]octanol-(2), 2-Methyl-bicyclo[2.2.2]octanol-(2) und cis-3-Methyl-bicyclo[3.2.1]octanol-(3) mit Jod, Phosphorsäure, Kaliumhydrogensulfat und p-Toluolsulfochlorid in Pyridin wird gaschromatographisch untersucht. Die Eliminierungen verlaufen teilweise unter Umlagerung, besonders in Gegenwart von Phosphorsäure. Neu synthetisiert werden 2-Methyl-bicyclo[3.2.1]octen-(2), 2-Methyl-bicyclo[2.2.2]octen-(2) und 3-Methyl-bicyclo[3.2.1]octen-(2) durch Dehydratisierung der entsprechenden tertiären Alkohole, 2-Methylen-bicyclo[3.2.1]octan, 2-Methylen-bicyclo[2.2.2]octan und 3-Methylen-bicyclo[3.2.1]octan durch Wittig-Reaktion aus den zugrundeliegenden Ketonen sowie 1-Methyl-bicyclo[2.2.2]octen-(2). Der Verlauf der Wasserabspaltungen wird diskutiert.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19656890103
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