ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

The agonistic binding site at the histamine H2 receptor. II. Theoretical investigations of histamine binding to receptor models of the seven α-helical transmembrane domain (1996)

Nederkoorn, Paul H. J. ; Gelder, Erna M. ; Donné-Op den Kelder, Gabriëlle M. ; [et al.]

Springer

Journal of computer aided molecular design 10 (1996), S. 479-489

add to mindlist on the mindlist

Details

ISSN: 1573-4951

Keywords: G-protein-coupled receptor ; Hartree-Fock calculations ; Histamine H2 receptor ; Molecular mechanics ; Receptor models

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Summary In the first part (pp. 461–478 in this issue) of this study regarding the histamine H2 receptor agonistic binding site, the best possible interactions of histamine with an α-helical oligopeptide, mimicking a part of the fifth transmembrane α-helical domain (TM5) of the histamine H2 receptor, were considered. It was established that histamine can only bind via two H-bonds with a pure α-helical TM5, when the binding site consists of Tyr182/Asp186 and not of the Asp186/Thr190 couple. In this second part, two particular three-dimensional models of G-protein-coupled receptors previously reported in the literature are compared in relation to agonist binding at the histamine H2 receptor. The differences between these two receptor models are discussed in relation to the general benefits and limitations of such receptor models. Also the pros and cons of simplifying receptor models to a relatively easy-to-deal-with oligopeptide for mimicking agonistic binding to an agonistic binding site are addressed. Within complete receptor models, the simultaneous interaction of histamine with both TM3 and TM5 can be analysed. The earlier suggested three-point interaction of histamine with the histamine H2 receptor can be explored. Our results demonstrate that a three-point interaction cannot be established for the Asp98/Asp186/Thr190 binding site in either of the investigated receptor models, whereas histamine can form three H-bonds in case the agonistic binding site is constituted by the Asp98/Tyr182/Asp186 triplet. Furthermore this latter triplet is seen to be able to accommodate a series of substituted histamine analogues with known histamine H2 agonistic activity as well.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00124477

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Mikrostrukturelle, mechanische und korrosive Eigenschaften reibrührgeschweißter Stumpfnähte in Aluminiumlegierungen (1998)

Donne, C. Dalle ; Braun, R. ; Staniek, G. ; [et al.]

Weinheim : Wiley-Blackwell

Materialwissenschaft und Werkstofftechnik 29 (1998), S. 609-617

add to mindlist on the mindlist

Details

ISSN: 0933-5137

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Description / Table of Contents: Microstructural, mechanical and corrosive properties of friction stir welded aluminium jointsFriction stir welding (FSW) is a novel solid state welding process. It allows joining of high strength aluminum alloys, generally considered as difficult-to-weld with conventional technologies, without loss in joint strength. Results of investigations on selfmade FSW butt joints of the aluminum alloys 2024-T3 and 6013-T4 are presented. First, the microstructure of the weld seam and heat affected zone is characterised metallographically and by hardness measurements. By tensile, fatigue endurance (SN) and fatigue crack propagation tests it is demonstrated, that especially the FSW-joints of 2024-T3 sustain high mechanical loadings. Investigations on the corrosion properties reveal a certain sensitivity of the 2024-T3 joints to intergranular and exfoliation corrosion.

Notes: Das Reibrührschweißen (friction stir welding FSW) ist ein neues Fügeverfahren, mit dem auch die schwer schmelzschweißbaren, höherfesten Aluminiumlegierungen ohne große Festigkeitsverluste verschweißt werden können. Erste Ergebnisse von Untersuchungen an selbst hergestellten FSW-Stumpfnähten der Aluminiumlegierungen 2024-T3 und 6013-T4 werden vorgestellt. Zunächst wird das Gefüge der Naht und der Wärmeeinflußzone mikrostrukturell und durch Härteverläufe charakterisiert. Weiterhin wird mit Zug-, Schwingfestigkeits- und Rißfortschrittsversuchen nachgewiesen, daß insbesondere die FSW-Nähte der Legierung 2024-T3 außerordentlich hohe mechanische Belastungen ertragen. Abschließende Korrosionsuntersuchungen der FSW-Nähte zeigen eine gewisse Anfälligkeit der abschreckempfindlichen Legierung 2024-T3 für interkristalline Korrosion und Schichtkorrosion.

Additional Material: 15 Ill.