Publication Date:
1995-06-30
Description:
CD25 expression occurs early in thymocyte differentiation. The mechanism of induction of CD25 before T cell receptor rearrangement and the importance of this mechanism for T cell development are unknown. In a thymus reconstitution assay, tumor necrosis factor alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha), two cytokines produced within the thymic microenvironment, induced CD25 expression on early immature thymocytes. Either TNF-alpha or IL-1 alpha was necessary for further thymocyte maturation and CD4+CD8+ differentiation. In irradiated mice reconstituted with CD117+CD25+ thymocytes, commitment to the T cell lineage was marked by the loss of precursor multipotency.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zuniga-Pflucker, J C -- Jiang, D -- Lenardo, M J -- New York, N.Y. -- Science. 1995 Jun 30;268(5219):1906-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7541554" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Differentiation
;
Cells, Cultured
;
Hematopoietic Stem Cells/*cytology/immunology
;
Interleukin-1/pharmacology/*physiology
;
Interleukin-7/pharmacology
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C57BL
;
Mice, SCID
;
Organ Culture Techniques
;
Proto-Oncogene Proteins/biosynthesis
;
Proto-Oncogene Proteins c-kit
;
Receptor Protein-Tyrosine Kinases/biosynthesis
;
Receptors, Colony-Stimulating Factor/biosynthesis
;
Receptors, Interleukin-2/*biosynthesis
;
Stromal Cells/physiology
;
T-Lymphocyte Subsets/cytology/immunology
;
T-Lymphocytes/*cytology/immunology
;
Thymus Gland/cytology/*embryology/immunology
;
Tumor Necrosis Factor-alpha/pharmacology/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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