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  • 1
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    Association of cdk2 kinase with the transcription factor E2F during S phase (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-02-28
    Description: The transcription factor E2F controls the expression of several proliferation-related genes and is a target of the adenovirus E1A oncogene. In human cells, both cyclin A and the cdk2 protein kinase were found in complexes with E2F. Although the total amounts of cdk2 were constant in the cell cycle, binding to E2F was detected only when cells entered S phase, a time when the cdk2 kinase is activated. These data suggest that the interaction between cdk2 and E2F requires an active kinase that has cyclin A as a targeting component.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pagano, M -- Draetta, G -- Jansen-Durr, P -- New York, N.Y. -- Science. 1992 Feb 28;255(5048):1144-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉European Molecular Biology Laboratory, Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1312258" target="_blank"〉PubMed〈/a〉
    Keywords: Adenovirus Early Proteins ; Base Sequence ; *CDC2-CDC28 Kinases ; *Carrier Proteins ; Cell Cycle ; *Cell Cycle Proteins ; Cyclin-Dependent Kinase 2 ; *Cyclin-Dependent Kinases ; Cyclins/*metabolism ; *DNA-Binding Proteins ; E2F Transcription Factors ; HeLa Cells ; Humans ; Macromolecular Substances ; Molecular Sequence Data ; Oligodeoxyribonucleotides/chemistry ; Oncogene Proteins, Viral/genetics ; Protamine Kinase/metabolism ; Protein Kinases/*metabolism ; *Protein-Serine-Threonine Kinases ; Retinoblastoma-Binding Protein 1 ; *S Phase ; Transcription Factor DP1 ; Transcription Factors/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27 (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-08-04
    Description: The p27 mammalian cell cycle protein is an inhibitor of cyclin-dependent kinases. Both in vivo and in vitro, p27 was found to be degraded by the ubiquitin-proteasome pathway. The human ubiquitin-conjugating enzymes Ubc2 and Ubc3 were specifically involved in the ubiquitination of p27. Compared with proliferating cells, quiescent cells exhibited a smaller amount of p27 ubiquitinating activity, which accounted for the marked increase of p27 half-life measured in these cells. Thus, the abundance of p27 in cells is regulated by degradation. The specific proteolysis of p27 may represent a mechanism for regulating the activity of cyclin-dependent kinases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pagano, M -- Tam, S W -- Theodoras, A M -- Beer-Romero, P -- Del Sal, G -- Chau, V -- Yew, P R -- Draetta, G F -- Rolfe, M -- New York, N.Y. -- Science. 1995 Aug 4;269(5224):682-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mitotix Inc., Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7624798" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Anaphase-Promoting Complex-Cyclosome ; Animals ; *Cell Cycle Proteins ; Cell Line ; Cyclin-Dependent Kinase Inhibitor p27 ; Cyclin-Dependent Kinases/*antagonists & inhibitors ; Cysteine Endopeptidases/*metabolism ; Electroporation ; Enzyme Inhibitors/metabolism ; Humans ; Kinetics ; Leupeptins/pharmacology ; Ligases/metabolism ; Mice ; Microtubule-Associated Proteins/*metabolism ; Multienzyme Complexes/*metabolism ; Proteasome Endopeptidase Complex ; Rabbits ; Recombinant Proteins/metabolism ; Succinates/pharmacology ; Tumor Cells, Cultured ; *Tumor Suppressor Proteins ; Ubiquitin-Conjugating Enzymes ; *Ubiquitin-Protein Ligase Complexes ; Ubiquitin-Protein Ligases ; Ubiquitins/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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