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  • Springer  (49)
  • De Gruyter  (7)
  • Blackwell Publishing Ltd  (5)
  • Oxford University Press  (1)
  • 1995-1999  (33)
  • 1990-1994  (13)
  • 1985-1989  (14)
  • 1975-1979
  • 1960-1964
  • 1870-1879  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Managing industrial pharmaceutical R&D. A comparative study of management control and innovative effectiveness in European and Anglo-American companies (1994)
    Oxford, UK : Blackwell Publishing Ltd
    R & D management 24 (1994), S. 0 
    Details
    ISSN: 1467-9310
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Drug regulation and pricing have put strong pressure on the cost-benefit ratio of the innovative pharmaceutical industry. Therefore a study has been conducted in fourteen large and medium sized companies to determine some important organisational and managerial factors influencing success in pharmaceutical innovation. The study consists of structured interviews with Research Directors and questionnaires, submitted to the heads of the different research departments. The following conclusions are tentatively drawn. Firstly, the data suggest that a threshold investment of approximately $150–200 million is needed to maintain the innovative potential. Above approximately $750 million, ‘economies of scale’ seem to appear in pharmaceutical innovation. Secondly, an incremental strategy aimed at reducing the duration of the development process seems to be more successful than a radical strategy which lays more emphasis on discovery. Thirdly, pure play pharmaceuticals seem to be more successful than the pharmaceutical divisions of conglomerates. Management control, especially the way in which reorganisations are performed, is assessed more positively in pure play pharmaceuticals. Fourthly, the greater emphasis on human resources management in Anglo-American companies, in comparison to continental European companies, seems to be an important explanatory factor for their greater success on the pharmaceutical market.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9310.1994.tb00886.x
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  • 2
    Electronic Resource
    Electronic Resource
    A Dutch test with the NewProd-Model (1988)
    Oxford, UK : Blackwell Publishing Ltd
    R & D management 18 (1988), S. 0 
    Details
    ISSN: 1467-9310
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: The paper contains a report of a test of Cooper's NewProd model for predicting success and failure of product development projects. Based on Canadian data, the model has been shown to make predictions which are 84% correct. Having reservations on the reliability and validity of the model on theoretical grounds, we set out to test it using data collected in the Netherlands.Following Cooper's methodology, we selected 19 projects, which had already been marketed and of which 9 were clearcut successes and 10 clearcut failures. We also studied 9 additional projects, which had not yet been commercialised, as the basis for a future a priori test. The projects were given a product score according to Cooper's criteria, and predictions compared with the actual experience. Eightyfour percent were correctly classified, as in Cooper's work. From a practical point of view however the variance was too large to allow the predictions from NewProd to be used with confidence to predict outcomes unless they are clearcut.We believe that the drawback of the methodology is that the product score is a simple combination of the various factors involved. No allowance is made for the possibility that one factor alone might be responsible for failure. We have therefore introduced the concept of a threshold value for each factor. A project for which any factor falls below this value will be deemed a failure. Based on a very limited sample of 19 cases an improvement of reliability was made to 95% of 18 out of 19 products correctly classified. The NewProd concept so modified is being applied to the sample of 9 as yet uncompleted projects, and its predictions will eventually be compared with actual outcomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9310.1988.tb00607.x
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  • 3
    Electronic Resource
    Electronic Resource
    Preface (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 788 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb36789.x
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  • 4
    Electronic Resource
    Electronic Resource
    Dedication (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 788 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb36790.x
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  • 5
    Electronic Resource
    Electronic Resource
    Borel Groups of Low Descriptive Complexity (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 788 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: Let X be a zero-dimensional first category absolute Borel set of ambiguous class two. Then X can be given the structure of a topological group if and only if X is homogeneous and X=X x X. Thus, within the ambiguous class two, zero-dimensional groups only occur at the low levels, and the indecomposable levels of the hierarchy of difference classes DαΣ02 in 2ω.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb36800.x
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  • 6
    Electronic Resource
    Electronic Resource
    An oxygen electrode for air-consuming proton exchange membrane fuel cells for transportation applications (1995)
    Springer
    Journal of applied electrochemistry 25 (1995), S. 122-125 
    Details
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Electrodes for air-driven PEMFCs for transport applications have been developed. The structure of the electrodes has been specifically adapted to run with air as oxidant under near atmospheric pressure; such electrodes can be manufactured using conventional industrial methods and be easily scaled up. The technology has been demonstrated on a 50 cm2 electrode area, assembled together with a Nafion® 117 membrane. Electrodes with different platinum loading, namely 0.4 and 0.2 mg Pt cm−2, have been the subject of long duration tests which show a slow degradation of the cell performance. With air as oxidant at 180 kPa absolute pressure, 80°C as cell temperature and Nafion® 117 as membrane, a power density of 350 mW cm−2 has been obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00248168
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  • 7
    Electronic Resource
    Electronic Resource
    Measurement ofJ/ψ and ψ′ real photoproduction on lithium-6 at a mean energy of 90 GeV (1987)
    Springer
    The European physical journal 33 (1987), S. 505-512 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Inelastic and elasticJ/ψ (3097) photoproduction on Li6 are measured at a mean γ energy of 90 GeV in an open spectrometer. TheJ/ψ are identified by their decays intoμ + μ − ore + e −. A signal of ψ′(3685) intoμ + μ − andJ/ψπ + π − is also seen. The inelastic cross-section withZ=E ψ/Eγ〈0.9 is compared in shape and magnitude with the colour singlet model of photon-gluon fusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01548261
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  • 8
    Electronic Resource
    Electronic Resource
    Het eisenacher (katheder-socialistisch) congres (1873)
    Springer
    De economist 22 (1873), S. 459-487 
    Details
    ISSN: 1572-9982
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02183330
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  • 9
    Electronic Resource
    Electronic Resource
    Het Eisenacher (Katheder-Socialistisch) Congres (1873)
    Springer
    De economist 22 (1873), S. 321-338 
    Details
    ISSN: 1572-9982
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02183323
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  • 10
    Electronic Resource
    Electronic Resource
    Colonic epithelium reactive monoclonal antibodies (1989)
    Springer
    Histochemistry and cell biology 92 (1989), S. 397-406 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We have produced a small library of colonic mucosa and colorectal carcinoma reactive monoclonal antibodies (MoAbs) by immunizations with extracts of human colon cancer tissue and a human colon cancer cell line. Hybridoma supernatants were tested on (normal and neoplastic) human tissues by immunoperoxidase methods to evaluate organ or tissue specificity. Initial biochemical characterization of the target antigens was performed by gelpermeation chromatography, Western blotting and competition assays. Based upon the immunoreactivity patterns and the characteristics of the antigen four groups of MoAbs could be distinguished. The first group concerns the antibodies PAR-LAM 3, 9 and 10. These antibodies react with an 87 kDa protein moiety in high molecular weight (2–5×106 Da) glycoproteins. In intestinal and colon mucosa these antibodies showed diffuse binding with goblet cells. In colon carcinoma decreased reactivity with these MoAbs was found. The second group consists of antibodies PARLAM 8, 12 and 13. These antibodies react with large (〉5×106 Da) glycoproteins, most likely with carbohydrate epitopes. By immunohistochemistry in normal colon mucosa the antibodies all show granular supranuclear reactivity with goblet cells. These antibodies show increased reactivity with colon adenomas and adenocarcinomas. A third group is formed by PARLAM 2, which also reacts with a large (〉5×106 Da) glycoprotein, showing a granular distribution in goblet cells. In colon carcinomas more extensive expression is found than in normal colonic mucosa. Finally, the fourth group consists of PARLAM 11, which also reacts with a large (〉5×106 Da) glycoprotein, located in the brush border of colonic columnar cells. These antibodies might be useful tools for the analysis of the expression of mucin related glycoproteins in normal, preneoplastic and neoplastic colon mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00492497
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