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  • 1995-1999  (66)
  • 1990-1994  (45)
  • 1985-1989  (37)
  • 1975-1979  (7)
  • 1960-1964  (1)
  • 1890-1899  (2)
  • 1870-1879  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    A Dutch test with the NewProd-Model (1988)
    Oxford, UK : Blackwell Publishing Ltd
    R & D management 18 (1988), S. 0 
    Details
    ISSN: 1467-9310
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: The paper contains a report of a test of Cooper's NewProd model for predicting success and failure of product development projects. Based on Canadian data, the model has been shown to make predictions which are 84% correct. Having reservations on the reliability and validity of the model on theoretical grounds, we set out to test it using data collected in the Netherlands.Following Cooper's methodology, we selected 19 projects, which had already been marketed and of which 9 were clearcut successes and 10 clearcut failures. We also studied 9 additional projects, which had not yet been commercialised, as the basis for a future a priori test. The projects were given a product score according to Cooper's criteria, and predictions compared with the actual experience. Eightyfour percent were correctly classified, as in Cooper's work. From a practical point of view however the variance was too large to allow the predictions from NewProd to be used with confidence to predict outcomes unless they are clearcut.We believe that the drawback of the methodology is that the product score is a simple combination of the various factors involved. No allowance is made for the possibility that one factor alone might be responsible for failure. We have therefore introduced the concept of a threshold value for each factor. A project for which any factor falls below this value will be deemed a failure. Based on a very limited sample of 19 cases an improvement of reliability was made to 95% of 18 out of 19 products correctly classified. The NewProd concept so modified is being applied to the sample of 9 as yet uncompleted projects, and its predictions will eventually be compared with actual outcomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9310.1988.tb00607.x
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  • 2
    Electronic Resource
    Electronic Resource
    Managing industrial pharmaceutical R&D. A comparative study of management control and innovative effectiveness in European and Anglo-American companies (1994)
    Oxford, UK : Blackwell Publishing Ltd
    R & D management 24 (1994), S. 0 
    Details
    ISSN: 1467-9310
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Drug regulation and pricing have put strong pressure on the cost-benefit ratio of the innovative pharmaceutical industry. Therefore a study has been conducted in fourteen large and medium sized companies to determine some important organisational and managerial factors influencing success in pharmaceutical innovation. The study consists of structured interviews with Research Directors and questionnaires, submitted to the heads of the different research departments. The following conclusions are tentatively drawn. Firstly, the data suggest that a threshold investment of approximately $150–200 million is needed to maintain the innovative potential. Above approximately $750 million, ‘economies of scale’ seem to appear in pharmaceutical innovation. Secondly, an incremental strategy aimed at reducing the duration of the development process seems to be more successful than a radical strategy which lays more emphasis on discovery. Thirdly, pure play pharmaceuticals seem to be more successful than the pharmaceutical divisions of conglomerates. Management control, especially the way in which reorganisations are performed, is assessed more positively in pure play pharmaceuticals. Fourthly, the greater emphasis on human resources management in Anglo-American companies, in comparison to continental European companies, seems to be an important explanatory factor for their greater success on the pharmaceutical market.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9310.1994.tb00886.x
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  • 3
    Electronic Resource
    Electronic Resource
    Preface (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 788 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb36789.x
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  • 4
    Electronic Resource
    Electronic Resource
    Dedication (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 788 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb36790.x
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  • 5
    Electronic Resource
    Electronic Resource
    Borel Groups of Low Descriptive Complexity (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 788 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: Let X be a zero-dimensional first category absolute Borel set of ambiguous class two. Then X can be given the structure of a topological group if and only if X is homogeneous and X=X x X. Thus, within the ambiguous class two, zero-dimensional groups only occur at the low levels, and the indecomposable levels of the hierarchy of difference classes DαΣ02 in 2ω.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb36800.x
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of preparation method on the metal cluster size of platinum/ZSM-5 catalysts as studied with EXAFS (1990)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 94 (1990), S. 8574-8578 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100386a017
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  • 7
    Electronic Resource
    Electronic Resource
    Attitude of laboratory personnel towards accreditation (1998)
    Bingley : Emerald
    International journal of health care quality assurance 11 (1998), S. 27-30 
    Details
    ISSN: 0952-6862
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Medicine , Economics
    Notes: A multiple choice questionnaire was submitted to medical technologists in three medical laboratories, at varying times after obtaining an EN 45001 accreditation. A large majority (85-90 per cent) considered that their workload was increased by the accreditation process. In two laboratories, the technologists did not think that the accreditation process had improved the quality of the results. The major advantages were the fact that everything was traceable, that the technologists felt more sure about the procedures to follow, received more responsibilities and had a better knowledge of the tests they performed. The major disadvantages were the increased paperwork, discrepancies between the procedures and the reality, the fact that more attention is paid to the formalities than to the quality of the results and that the accreditation process decreased the adaptability. The number of advantages mentioned seemed to increase with the interval since the accreditation. A small majority of the technologists preferred working in an accredited laboratory than in a non accredited one.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09526869810199629
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  • 8
    Electronic Resource
    Electronic Resource
    Tunicamycin-inhibited carrot somatic embryogenesis can be restored by secreted cationic peroxidase isoenzymes (1991)
    Springer
    Planta 184 (1991), S. 478-486 
    Details
    ISSN: 1432-2048
    Keywords: Daucus (somatic embryogenesis) ; Embryogenesis (somatic) ; Peroxidase, cationic (isoenzymes) ; Protein glycosylation ; Glycoprotein secretion ; Somatic embryogenesis ; Tunicamycin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Somatic embryogenesis of carrot (Daucus carota L.) is inhibited by the glycosylation inhibitor tunicamycin. This inhibition is reversible by the addition of correctly glycosylated glycoproteins which have been secreted into the culture medium. To identify the proteins responsible for complementation, glycoproteins present in the medium of embryo cultures were purified and tested for their activity in the tunicamycin inhibition/ complementation assay. A 38-kDa glycoprotein was purified that could restore embryogenesis to more than 50% of that in untreated controls. This 38-kDa glycoprotein was identified as a heme-containing peroxidase on the basis of its A405/A280 ratio (Reinheit Zahl or RZ) and enzyme activity. The 38-kDa peroxidase consisted of four different cationic isoenzymes of which only one or possibly two appeared active in the complementation assay. The cationic peroxidase isoenzymes from the carrot medium could be effectively replaced by cationic horseradish peroxidases which depended on their catalytic properties for their ability to restore tunicamycin-inhibited somatic embryogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197895
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  • 9
    Electronic Resource
    Electronic Resource
    A New Acid Selenite: Mg(HSeO3)2 (1997)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 53 (1997), S. 666-668 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270197000462
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  • 10
    Electronic Resource
    Electronic Resource
    Intralayer Hydrogen Bonding in CdSeO3.H2O (1998)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 54 (1998), S. 169-171 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270197014042
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