Publication Date:
2004-07-13
Description:
Intestinal intraepithelial T lymphocytes (IELs) are likely to play a key role in host mucosal immunity and, unlike other T cells, have been proposed to differentiate from local precursors rather than from thymocytes. We show here that IELs expressing the alphabeta T cell receptor are derived from precursors that express RORgammat, an orphan nuclear hormone receptor detected only in immature CD4+CD8+ thymocytes, fetal lymphoid tissue-inducer (LTi) cells, and LTi-like cells in cryptopatches within the adult intestinal lamina propria. Using cell fate mapping, we found that all intestinal alphabeta T cells are progeny of CD4+CD8+ thymocytes, indicating that the adult intestine is not a significant site for alphabeta T cell development. Our results suggest that intestinal RORgammat+ cells are local organizers of mucosal lymphoid tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eberl, Gerard -- Littman, Dan R -- New York, N.Y. -- Science. 2004 Jul 9;305(5681):248-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15247480" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD4/analysis
;
Antigens, CD8/analysis
;
Cell Lineage
;
DNA-Binding Proteins/metabolism
;
Hematopoietic Stem Cells/immunology/physiology
;
Immunity, Mucosal
;
Intestinal Mucosa/cytology/*immunology
;
Lymphoid Tissue/embryology/immunology
;
Mice
;
Mice, Transgenic
;
Nuclear Receptor Subfamily 1, Group F, Member 3
;
Receptors, Antigen, T-Cell, alpha-beta/*analysis/genetics
;
Receptors, Antigen, T-Cell, gamma-delta/analysis/genetics
;
Receptors, Retinoic Acid/genetics/*metabolism
;
Receptors, Thyroid Hormone/genetics/*metabolism
;
T-Lymphocyte Subsets/cytology/*immunology
;
T-Lymphocytes/cytology/*immunology
;
Thymus Gland/cytology/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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