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  • Life Sciences (General)  (3)
  • Geophysics  (1)
  • 2000-2004  (4)
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  • 1
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    Fatal Saccharomyces Cerevisiae Aortic Graft Infection (2002)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: Saccharomyces cerevisiae is a yeast commonly used in baking and a frequent colonizer of human mucosal surfaces. It is considered relatively nonpathogenic in immunocompetent adults. We present a case of S. cerevisiae fungemia and aortic graft infection in an immunocompetent adult. This is the first reported case of S. cerevisiue fungemia where the identity of the pathogen was confirmed by rRNA sequencing.
    Keywords: Life Sciences (General)
    Type: Journal of Clinical Microbiology (ISSN 0095-1137); 40; 7; 2691-2692
    Format: text
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  • 2
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    The Grand Assault (2003)
    In:  Other Sources
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    Publication Date: 2019-07-10
    Description: Plasmodium falciparum, the protozoan parasite responsible for most human malaria, is among the most studied pathogens of all time, probably only exceeded by the human immunodeficiency virus HTV and the bacterium Mycobacterium tuberculosis. The extent of human suffering and the devastating costs of malaria have long been recognized by world bodies, and numerous initiatives have been taken over the years in an effort to defeat this insidious microbe. Beginning in 1996, an international consortium of scientists from more than a dozen institutions set about to determine the sequence of the organism's 23-megabase genome. Their massive effort-which ended up going well beyond simple sequencing is reported in this special issue of Nature. The avowed goal of the project was to search for chinks in the parasite's armor so that new and effective drugs and vaccines might be developed.
    Keywords: Life Sciences (General)
    Type: Nature News and Views: Special Malaria Issue
    Format: text
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  • 3
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    Prebiotic Synthesis from CO Atmospheres: Implications for the origins of life (2002)
    In:  Other Sources
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    Publication Date: 2019-07-10
    Description: Most models of the primitive atmosphere around the time life originated suggest that the atmosphere was dominated by carbon dioxide, largely based on the notion that the atmosphere was derived via volcanic outgassing, and that those gases were similar to those found in modern volcanic effluent. These models tend to downplay the possibility of a strongly reducing atmosphere, which had been thought to be important for prebiotic synthesis and thus the origin of life. However, there is no definitive geologic evidence for the oxidation state of the early atmosphere and bioorganic compounds are not efficiently synthesized from CO2 atmospheres. In the present study, it was shown that a CO-CO2-N2-H2O atmosphere can give a variety of bioorganic compounds with yields comparable to those obtained from a strongly reducing atmosphere. Atmospheres containing carbon monoxide might therefore have been conducive to prebiotic synthesis and perhaps the origin of life. CO-dominant atmospheres could have existed if the production rate of CO from impacts of extraterrestrial materials were high or if the upper mantle had been more reduced than today.
    Keywords: Geophysics
    Type: PNAS Early Edition
    Format: text
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  • 4
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    Emergence of RNA and Early Life; Experimental Modeling and Geochemical Constraints (2002)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Support from this grant continues to fund our research on two related problems. One involves attempts to model the abiotic formation of simple source compounds for functional biomolecules, their concentration from dilute state in the hydrosphere and in several cases surface induced reactions to form precursor monomers for bioactive end products. The second area is a search for the earliest traces of life on Earth and the early environments on Earth and Mars. For this purpose we have analyzed the isotopic compositions of carbon and nitrogen in graphitic residues that have been thought to represent the remains of microorganisms. The results of these studies have been presented in a number of publication, listed as references.
    Keywords: Life Sciences (General)
    Type: Rept-99-1436R1
    Format: text
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