Publication Date:
2001-05-12
Description:
In eukaryotic cells, microtubules and their associated motor proteins can be organized into various large-scale patterns. Using a simplified experimental system combined with computer simulations, we examined how the concentrations and kinetic parameters of the motors contribute to their collective behavior. We observed self-organization of generic steady-state structures such as asters, vortices, and a network of interconnected poles. We identified parameter combinations that determine the generation of each of these structures. In general, this approach may become useful for correlating the morphogenetic phenomena taking place in a biological system with the biophysical characteristics of its constituents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Surrey, T -- Nedelec, F -- Leibler, S -- Karsenti, E -- New York, N.Y. -- Science. 2001 May 11;292(5519):1167-71.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cell Biology and Biophysics Program, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11349149" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine Triphosphate/metabolism
;
Animals
;
Antibodies
;
Biopolymers/chemistry/metabolism
;
*Computer Simulation
;
*Drosophila Proteins
;
Guanosine Triphosphate/metabolism
;
Kinesin/chemistry/metabolism
;
Kinetics
;
Macromolecular Substances
;
Microtubules/*chemistry/drug effects/*metabolism
;
Models, Molecular
;
Molecular Motor Proteins/*chemistry/*metabolism
;
Paclitaxel/pharmacology
;
Protein Structure, Quaternary/drug effects
;
Tubulin/chemistry/metabolism
;
Viscosity
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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