Publication Date:
2003-12-06
Description:
In vitro studies have indicated that reactive oxygen species (ROS) and the oxidation of signaling molecules are important mediators of signal transduction. We have identified two pathways by which the altered redox chemistry of the clk-1 mutants of Caenorhabditis elegans acts in vivo on germline development. One pathway depends on the oxidation of an analog of vertebrate low density lipoprotein (LDL) and acts on the germline through the Ack-related tyrosine kinase (ARK-1) kinase and inositol trisphosphate (IP3) signaling. The other pathway is the oncogenic ras signaling pathway, whose action on germline as well as vulval development appears to be modulated by cytoplasmic ROS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shibata, Yukimasa -- Branicky, Robyn -- Landaverde, Irene Oviedo -- Hekimi, Siegfried -- New York, N.Y. -- Science. 2003 Dec 5;302(5651):1779-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montreal, Quebec, Canada, H3A 1B1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14657502" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Apolipoproteins B/genetics/metabolism
;
Base Sequence
;
Caenorhabditis elegans/genetics/*growth & development/*metabolism
;
Caenorhabditis elegans Proteins/chemistry/genetics/metabolism
;
Cholesterol/metabolism
;
Cloning, Molecular
;
Disorders of Sex Development
;
Female
;
Inositol Phosphates/metabolism
;
Lipoproteins, LDL/*metabolism
;
Molecular Sequence Data
;
Mutation
;
Oxidation-Reduction
;
Phenotype
;
Protein-Tyrosine Kinases/metabolism
;
RNA Interference
;
Reactive Oxygen Species/*metabolism
;
Transcription Factors/genetics/metabolism
;
Vulva/growth & development
;
ras Proteins/genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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