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  • hydrophilic solid supports  (2)
  • Aerospace Medicine  (1)
  • Bathymetric data
  • Magnetism
  • Trap fishing
  • 2000-2004  (3)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Peptide synthesis containing a B-cell and a T-cell epitope on dextran beads and evaluation of humoral response against bead-peptide construct (2000)
    Springer
    International journal of peptide research and therapeutics 7 (2000), S. 229-237 
    Details
    ISSN: 1573-3904
    Keywords: hydrophilic solid supports ; solid-phase peptide synthesis ; synthetic peptides ; HIV-1 ; V3 loop
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Cross-linked dextran beads were chemically modified with Fmoc-βAla to give an amino functionalized support suitable for solid-phase peptide synthesis. On this support, a peptide compriising B-cell and T-cell epitopes in tandem was synthesized manually by Fmoc procedure monitoring the coupling reaction by bromophenol blue procedure and standard Kaiser test. The quality of peptide synthesis was verified by RP-HPLC and mass spectrometry. The size and morphologic characteristics of dextran beads were conserved after peptide synthesis. Furthermore, we analyzed immunogenicity in mice of the T-B peptide on dextran beads compared with T-B peptide immunogenicity when administered in CFA/IFA. In both cases, titers were high and there was not a significant difference in antibody titers between groups (p〈0.05). But in contrast CFA they are biocompatible and did not induce any adverse reaction at the site of injection. This experiment suggests that the peptides synthesis on dextran beads can be used to raise the immunogenicity of synthetic peptide in vaccines or therapeutics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02447862
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Peptide synthesis containing a B-cell and a T-cell epitope on dextran beads and evaluation of humoral response against bead-peptide construct (2000)
    Springer
    International journal of peptide research and therapeutics 7 (2000), S. 229-237 
    Details
    ISSN: 1573-3904
    Keywords: hydrophilic solid supports ; solid-phase peptide synthesis ; synthetic peptides ; HIV-1 ; V3 loop
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Cross-linked dextran beads were chemically modified withFmoc-βAla to give an amino functionalized support suitablefor solid-phase peptide synthesis. On this support, apeptide comprising B-cell and T-cell epitopes in tandem wassynthesized manually by Fmoc procedure monitoring thecoupling reaction by bromophenol blue procedure andstandard Kaiser test. The quality of peptide synthesis wasverified by RP-HPLC and mass spectrometry. The size andmorphologic characteristics of dextran beads were conservedafter peptide synthesis. Furthermore, we analyzedimmunogenicity in mice of the T-B peptide on dextran beadscompared with T-B peptide immunogenicity when administeredin CFA/IFA. In both cases, titers were high and there wasnot a significant difference in antibody titers betweengroups (p〈0.05). But in contrast CFA they are biocompatibleand did not induce any adverse reaction at the site ofinjection. This experiment suggests that the peptidessynthesis on dextran beads can be used to raise theimmunogenicity of synthetic peptide in vaccines ortherapeutics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1011201104069
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    Paper (German National Licenses)
    Fulltext
  • 3
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    Unknown
    Marked exacerbation of orthostatic intolerance after long- vs. short-duration spaceflight in veteran astronauts (2001)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: OBJECTIVE: The incidence of postflight orthostatic intolerance after short-duration spaceflight is about 20%. However, the incidence after long-duration spaceflight was unknown. The purpose of this study was to test the hypothesis that orthostatic intolerance is more severe after long-duration than after short-duration flight. METHODS: We performed tilt tests on six astronauts before and after long-duration (129-190 days) spaceflights and compared these data with data obtained during stand tests before and after previous short-duration missions. RESULTS: Five of the six astronauts studied became presyncopal during tilt testing after long-duration flights. Only one had become presyncopal during stand testing after short-duration flights. We also compared the long-duration flight tilt test data to tilt test data from 20 different astronauts who flew on the short-duration Shuttle missions that delivered and recovered the astronauts to and from the Mir Space Station. Five of these 20 astronauts became presyncopal on landing day. Heart rate responses to tilt were no different between astronauts on long-duration flights and astronauts on short-duration flights, but long-duration subjects had lower stroke volumes and cardiac outputs than short-duration presyncopal subjects, suggesting a possible decrease in cardiac contractile function. One subject had subnormal norepinephrine release with upright posture after the long flight but not after the short flight. Plasma volume losses were not greater after long flights. CONCLUSION: Long-duration spaceflight markedly increases orthostatic intolerance, probably with multiple contributing factors.
    Keywords: Aerospace Medicine
    Type: Psychosomatic medicine (ISSN 0033-3174); 63; 6; 865-73
    Format: text
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    NASA TECHNICAL REPORTS
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