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  • 1
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    Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-02-26
    Description: Most types of antibiotic resistance impose a biological cost on bacterial fitness. These costs can be compensated, usually without loss of resistance, by second-site mutations during the evolution of the resistant bacteria in an experimental host or in a laboratory medium. Different fitness-compensating mutations were selected depending on whether the bacteria evolved through serial passage in mice or in a laboratory medium. This difference in mutation spectra was caused by either a growth condition-specific formation or selection of the compensated mutants. These results suggest that bacterial evolution to reduce the costs of antibiotic resistance can take different trajectories within and outside a host.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bjorkman, J -- Nagaev, I -- Berg, O G -- Hughes, D -- Andersson, D I -- New York, N.Y. -- Science. 2000 Feb 25;287(5457):1479-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10688795" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Anti-Bacterial Agents/*pharmacology ; *Antiporters ; Carrier Proteins/genetics ; Culture Media ; Drug Resistance, Microbial/*genetics ; Escherichia coli Proteins ; Evolution, Molecular ; Female ; Fusidic Acid/pharmacology ; Membrane Proteins/genetics ; Mice ; Mice, Inbred BALB C ; *Mutation ; Peptide Elongation Factor G/genetics ; Ribosomal Proteins/genetics ; Salmonella typhimurium/*drug effects/*genetics/growth & development/metabolism ; Selection, Genetic ; Serial Passage ; Streptomycin/pharmacology ; Suppression, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A global paleoclimate observing system (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alverson, K -- Bradley, R -- Briffa, K -- Cole, J -- Hughes, M -- Larocque, I -- Pedersen, T -- Thompson, L -- Tudhope, S -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):47-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11444288" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Dioxide/metabolism ; *Climate ; Cnidaria/physiology ; Conservation of Natural Resources ; Greenhouse Effect ; Humans ; Ice ; Oceans and Seas ; Rain ; Seawater/analysis/chemistry ; Specimen Handling/*methods ; Temperature ; Time Factors ; Trees/growth & development/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Historical overfishing and the recent collapse of coastal ecosystems (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-07-28
    Description: Ecological extinction caused by overfishing precedes all other pervasive human disturbance to coastal ecosystems, including pollution, degradation of water quality, and anthropogenic climate change. Historical abundances of large consumer species were fantastically large in comparison with recent observations. Paleoecological, archaeological, and historical data show that time lags of decades to centuries occurred between the onset of overfishing and consequent changes in ecological communities, because unfished species of similar trophic level assumed the ecological roles of overfished species until they too were overfished or died of epidemic diseases related to overcrowding. Retrospective data not only help to clarify underlying causes and rates of ecological change, but they also demonstrate achievable goals for restoration and management of coastal ecosystems that could not even be contemplated based on the limited perspective of recent observations alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jackson, J B -- Kirby, M X -- Berger, W H -- Bjorndal, K A -- Botsford, L W -- Bourque, B J -- Bradbury, R H -- Cooke, R -- Erlandson, J -- Estes, J A -- Hughes, T P -- Kidwell, S -- Lange, C B -- Lenihan, H S -- Pandolfi, J M -- Peterson, C H -- Steneck, R S -- Tegner, M J -- Warner, R R -- New York, N.Y. -- Science. 2001 Jul 27;293(5530):629-37.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0244, USA. jbcj@ucsd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11474098" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Archaeology ; Bacteria ; Cnidaria ; Conservation of Natural Resources ; *Ecosystem ; Eutrophication ; *Fishes ; Geologic Sediments ; Humans ; *Marine Biology ; Seaweed ; Shellfish ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Coral reef biodiversity and conservation (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baird, Andrew H -- Bellwood, David R -- Connell, Joseph H -- Cornell, Howard V -- Hughes, Terry P -- Karlson, Ronald H -- Rosen, Brian R -- New York, N.Y. -- Science. 2002 May 10;296(5570):1026-8; author reply 1026-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004903" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Climate ; *Cnidaria ; *Conservation of Natural Resources ; *Ecosystem ; Nephropidae ; Seawater ; Snails
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Regional-scale assembly rules and biodiversity of coral reefs (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-05-26
    Description: Tropical reef fishes and corals exhibit highly predictable patterns of taxonomic composition across the Indian and Pacific Oceans. Despite steep longitudinal and latitudinal gradients in total species richness, the composition of these key taxa is constrained within a remarkably narrow range of values. Regional-scale variation in reef biodiversity is best explained by large-scale patterns in the availability of shallow-water habitat. Once habitat area is accounted for, there is surprisingly little residual effect of latitude or longitude. Low-diversity regions are most vulnerable to human impacts such as global warming, underscoring the urgent need for integrated management at multinational scales.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bellwood, D R -- Hughes, T P -- New York, N.Y. -- Science. 2001 May 25;292(5521):1532-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Coral Reef Biodiversity, Department of Marine Biology, James Cook University, Townsville, Qld 4811, Australia. david.bellwood@jcu.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11375488" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cnidaria/classification/physiology ; Conservation of Natural Resources ; *Ecosystem ; *Fishes/classification/physiology ; Geography ; Greenhouse Effect ; Indian Ocean ; Pacific Ocean ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Global trajectories of the long-term decline of coral reef ecosystems (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-08-16
    Description: Degradation of coral reef ecosystems began centuries ago, but there is no global summary of the magnitude of change. We compiled records, extending back thousands of years, of the status and trends of seven major guilds of carnivores, herbivores, and architectural species from 14 regions. Large animals declined before small animals and architectural species, and Atlantic reefs declined before reefs in the Red Sea and Australia, but the trajectories of decline were markedly similar worldwide. All reefs were substantially degraded long before outbreaks of coral disease and bleaching. Regardless of these new threats, reefs will not survive without immediate protection from human exploitation over large spatial scales.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pandolfi, John M -- Bradbury, Roger H -- Sala, Enric -- Hughes, Terence P -- Bjorndal, Karen A -- Cooke, Richard G -- McArdle, Deborah -- McClenachan, Loren -- Newman, Marah J H -- Paredes, Gustavo -- Warner, Robert R -- Jackson, Jeremy B C -- New York, N.Y. -- Science. 2003 Aug 15;301(5635):955-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Paleobiology, MRC-121, National Museum of Natural History, Post Office Box 37012, Smithsonian Institution, Washington, DC 20013-7012, USA. pandolfi.john@nmnh.si.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12920296" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anthozoa/*growth & development ; Conservation of Natural Resources ; Culture ; *Ecosystem ; Humans ; Population Dynamics ; Principal Component Analysis ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Climate change, human impacts, and the resilience of coral reefs (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-08-16
    Description: The diversity, frequency, and scale of human impacts on coral reefs are increasing to the extent that reefs are threatened globally. Projected increases in carbon dioxide and temperature over the next 50 years exceed the conditions under which coral reefs have flourished over the past half-million years. However, reefs will change rather than disappear entirely, with some species already showing far greater tolerance to climate change and coral bleaching than others. International integration of management strategies that support reef resilience need to be vigorously implemented, and complemented by strong policy decisions to reduce the rate of global warming.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, T P -- Baird, A H -- Bellwood, D R -- Card, M -- Connolly, S R -- Folke, C -- Grosberg, R -- Hoegh-Guldberg, O -- Jackson, J B C -- Kleypas, J -- Lough, J M -- Marshall, P -- Nystrom, M -- Palumbi, S R -- Pandolfi, J M -- Rosen, B -- Roughgarden, J -- New York, N.Y. -- Science. 2003 Aug 15;301(5635):929-33.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Coral Reef Biodiversity, James Cook University, Townsville, Qld 4811, Australia. terry.hughes@jcu.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12920289" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptation, Biological ; Animals ; Anthozoa/growth & development/*physiology ; *Climate ; *Conservation of Natural Resources ; *Ecosystem ; Environment ; Fishes ; Greenhouse Effect ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Regulation of heat shock protein message in Jurkat cells cultured under serum-starved and gravity-altered conditions (2000)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: Although our understanding of effects of space flight on human physiology has advanced significantly over the past four decades, the potential contribution of stress at the cellular and gene regulation level is not characterized. The objective of this ground-based study was to evaluate stress gene regulation in cells exposed to altered gravity and environmentally suboptimal conditions. We designed primers to detect message for both the constitutive and inducible forms of the heat shock protein, HSP-70. Applying the reverse transcriptase-polymerase chain reaction (RT-PCR), we probed for HSP-70 message in human acute T-cell leukemia cells, Jurkat, subjected to three types of environmental stressors: (1) altered gravity achieved by centrifugation (hypergravity) and randomization of the gravity vector in rotating bioreactors, (2) serum starvation by culture in medium containing 0.05% serum, and (3) temperature elevation (42 degrees C). Temperature elevation, as the positive control, significantly increased HSP-70 message, while centrifugation and culture in rotating bioreactors did not upregulate heat shock gene expression. We found a fourfold increase in heat shock message in serum-starved cells. Message for the housekeeping genes, actin and cyclophilin, were constant and comparable to unstressed controls for all treatments. We conclude that gravitational perturbations incurred by centrifugal forces, exceeding those characteristic of a Space Shuttle launch (3g), and culture in rotating bioreactors do not upregulate HSP-70 gene expression. In addition, we found RT-PCR useful for evaluating stress in cultured cells. Copyright 2000 Wiley-Liss, Inc.
    Keywords: Aerospace Medicine
    Type: Journal of cellular biochemistry (ISSN 0730-2312); Volume 77; 1; 127-34
    Format: text
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  • 9
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    A Direct Approach for Minimum Fuel Maneuvers of Distributed Spacecraft in Multiple Flight Regimes (2004)
    In:  CASI
    Details
    Publication Date: 2018-06-06
    Description: In this work we present a method to solve the impulsive minimum fuel maneuver problem for a distributed set of spacecraft. We develop the method assuming a fully non-linear dynamics model and parameterize the problem to allow the method to be applicable to any flight regime. Furthermore, the approach is not limited by the inter-spacecraft separation distances and is applicable to both small formations as well as constellations. We assume that the desired relative motion is driven by mission requirements and has been determined a-priori. The goal of this work is to develop a technique to achieve the desired relative motion in a minimum fuel manner. To permit applicability to multiple flight regimes, we have chosen to parameterize the cost function in terms of the maneuver times expressed in a useful time system and the maneuver locations expressed in their Cartesian vector representations. We also include as an independent variable the initial reference orbit to solve for the optimal injection orbit to minimize and equalize the fuel expenditure of distributed sets of spacecraft with large inter-spacecraft separations. In this work we derive the derivatives of the cost and constraints with respect to all of the independent variables.
    Keywords: Astrodynamics
    Format: application/pdf
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  • 10
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    Optimal Orbit Design for the Magnetospheric Imaging Constellation (2001)
    In:  Other Sources
    Details
    Publication Date: 2019-07-17
    Description: The Magnetospheric Imaging Constellation (MagIC) is a NASA space science concept to study the Earth's Magnetosphere. The concept proposes to apply tomography techniques using an array of spacecraft to obtain three dimensional images of the Earth's magnetosphere. This paper presents an optimal orbit design to ensure that the constellation is in the desired region of the magnetosphere for maximum time. The solution is found using a steepest descent optimization algorithm that takes into account perturbations from the non-spherical Earth, drag, Sun, Moon and other significant bodies. The solution also satisfies constraints on maximum eclipse duration and geometry constraints to allow an adequate GPS navigation solution. We present three solutions depending upon the epoch of the primary science: vernal equinox, summer solstice, and a third midway between the vernal equinox and summer solstice. Orbit insertion is also considered. All spacecraft are assumed to be launched on a single vehicle into a nominal orbit and the (Delta)V's to achieve the nominal orbit are presented. After insertion into the nominal orbit, each spacecraft undergoes a phasing maneuver to place it in the appropriate position with respect to the rest of the constellation. We present a minimum fuel approach to maneuver each spacecraft from the nominal orbit into the desired final orbit.
    Keywords: Astrodynamics
    Type: 16th International Symposium on Space Flight Dynamics; Pasadena, CA; United States
    Format: text
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